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Regular nicotine intake increased tooth movement velocity,osteoclastogenesis and orthodontically induced dental root resorptions in a rat model

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International Journal of Oral Science 2017年第3期9卷 174-184页

作者： christian kirschneck michael maurer michael wolf claudia reicheneder peter proff department of orthodontics university medical centre of regensburgRegensburgGermany department of oral and maxillofacial surgery university medical centre of regensburgRegensburgGermany department of orthodontics rheinische friedrich wilhelm university of bonnBonnGermany

Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further （side） effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each （A/B/C） to 3 experimental groups （7 rats, 112/3）. （A） cone-beam-computed tomography （CBCT）; （B） histology/serology; （C） reverse- transcription quantitative real-time polymerase chain reaction （RT-qPCR）/cotinine serology--（1） control; （2） orthodontic tooth movement （OTM） of the first and second upper left molar （NiTi closed coil spring, 0.25 N）; （3） OTM with 1.89 mg-kg- 1 per day s.c. of L（- ）-nicotine. After 14 days of OTM, serum cotinine and IL-6 concentration as well as orthodontically induced inflammatory root resorption （OIIRR）, osteoclast activity （histology）, orthodontic tooth movement velocity （CBCT, within 14 and 28 days of OTM） and relative gene expression of known inflammatory and osteoclast markers were quantified in the dental-periodontal tissue （RT-qPCR）. Animals exposed to nicotine showed significantly heightened serum cotinine and IL-6 levels corresponding to those of regular European smokers. Both the extent of root resorption, osteoclast activity, orthodontic tooth movement and gene expression of inflammatory and osteoclast markers were significantly increased compared to controls with and without OTM under the influence of nicotine. We conclude that apart from increased periodontal bone loss, a progression of dental root resorption and accelerated orthodontic tooth movement are to be anticipated during orthodontic therapy, if nicotine consumption is present. Thus patients should be informed about these risks and the necessity of nicotine abstinence during treatment.

关键词： dental research inbred Fischer344 nicotine orthodontics rats root resorption tooth movement

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Three-dimensional Finite Element Analysis of the Mechanical Stress on Root from Orthodontic tooth movement by Sliding Mechanics

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第6期27卷 745-747页

作者：李平毛靖彭周谢晖 Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology College of Material Science Huazhong University of Science and Technology

In order to study mechanical stress on root from orthodontic tooth movement by sliding mechanics, a 3-dimensional finite element model incorporating all layers of a human mandibular dental arch with orthodontic appliance has been developed to simulate mechanical stress on root from the orthodontic tooth movement. Simulated orthodontic force of 2 N at 0, 30 and 45 degree from the horizontal axis was applied to the crown of the teeth. The finite element analysis showed when orthodontic forces were applied to the tooth, the stress was mainly concentrated at the neck of the tooth decreasing uniformly to the apex and crown. The highest stress on the root was 0.621 N/mm^2 for cervical margin of the canine, and 0.114 N/mm^2 for apical region of the canine. The top of canine crown showed the largest amount of displacement （2.417 μm）, while the lowest amount of displacement was located at the apical region of canine （0.043 μm）. In conclusion, this model might enable one to simulate orthodontic tooth movements clinically. Sliding force at 2 N is ideal to ensure the bodily orthodontic tooth movement. The highest stress concentration in the roots was always localized at the cervical margin when orthodontic force of 2 N at 0, 30 and 45 degree from the horizontal axis, so there may be the same risk of root resorption when orthodontic force of 2 N at 0, 30 and 45 degree was used in clinic cases.

关键词： tooth movement finite element methods sliding mechanics

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Sclerostin regulation:a promising therapy for periodontitis by modulating alveolar bone

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Chinese Medical Journal 2020年第12期133卷 1456-1461页

作者： Tian-Jiao Li Rui Wang Qin-Yang Li Chun-Yu Li Li Jiang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

Periodontitis is one of the most prevalent epidemics affecting human health and life recently,and exploration of the pathogenesis and treatment of periodontitis has been valued by *** recent years,sclerostin,a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation,has been a research *** article summarizes the researches on sclerostin in periodontitis development in recent *** them,sclerostin has been shown to be a critical negative regulator of bone formation,thereby inhibiting bone remodeling in periodontitis development,and is closely associated with tooth ***,evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from *** of sclerostin expression is a novel,promising treatment for periodontitis and addresses several complications seen with traditional therapies;accordingly,many drugs with similar mechanisms have ***,the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising *** are also a lot of drugs that regulate ***-sclerostin antibody(Scl-Ab)is the most direct one that inhibits bone resorption caused by *** present,drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and ***,the application of sclerostin in the oral field is just around the corner,which provides a new therapeutic bone regulation strategy in oral and general health.

关键词： Sclerostin Periodontitis Orthodontics tooth movement Mechanical forces Adjunctive therapy

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Changes of alveolar bone after retraction in ClassⅠmalocclusion patients

Changes of alveolar bone after retraction in ClassⅠmalocclu...

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第10次全国口腔颌面医学影像学专题研讨会暨国家级口腔颌面医学影像诊断学新进展学习班

作者： Jinyin Pei~(1,2),Zuolin Jin~2,DMD,Jinwu Chen~(1,2) DMD 1 Radiology and 2 Orthodontology Dept.Fourth Military Medical University School of Stomatology

Aims:This clinical study was performed to evaluate the changes in anterior teeth’s thickness of labial and lingual alveolar bone during incisor retraction in the maxilla and mandible. Methods:A total of 12 adult pati... 详细信息

关键词： tooth movement incisors retraction alveolar bone

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Biologically–accelerated orthodontics:A systematic review

Biologically–accelerated orthodontics:A systematic review

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第十三次全国口腔正畸学术会议（2014年会）

作者：封小霞李宇赵志河浙江大学医学院附属口腔医院四川大学华西口腔医学院

Numerous studieshave been and are attempted to develop adjunctive approaches to accelerateorthodontic tooth movement(OTM).So far,there are only sporadic clinical studieswith limited success,and the most efforts have been made in animal *** was,for the first time,to systematically evaluate the designs and findingsof the animal studies aimed at biologically-accelerated orthodontics(BAO).Literaturesearches were performed through Medline,Pub Med,Embase and ***,conversion,quality assessment and statistical analysis werecarried out by 2 reviewers independently.39 studies were *** existed in the experimental designs,including animal species andages,sample size,target tooth,force application technique,OTM measurement approaches,and observation *** approaches were sorted into3 major categories,i.e.,surgery,drug and physical *** and drugs both seemed to havepositive effects for OTM acceleration;however,the surgery-induced effectsattenuated drastically in the long *** effects of various physicalstimulations,on the other hand,remained *** conclusion,the considerablevariations in experimental designs have undermined cross-study comparison and abolishedcombination of data for *** protocols and guidelines shouldbe suggested for BAO animal studies in future.

关键词： tooth movement acceleration systematic review

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