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Inhibitory effect of celecoxib combined with cisplatin on growth of human tongue squamous carcinoma Tca8113 cell xenograft tumor

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The Chinese-German Journal of Clinical Oncology 2010年第10期9卷 564-568页

作者： Weizhong Li Xiaoyan Wang Zuguo Li Yanqing Ding Department of Oral and Maxillofacial Surgery Nanfang Hospital Southern Medical University Guangzhou 510515 China Department of Pathology School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China

Objective:The aim of this study was to observe the inhibitory effect of application of COX-2 inhibitor,celecoxib,combined with cisplatin on the growth of human tongue squamous carcinoma Tca8113 cell xenograft by animal ***:The nude mice were transplanted subcutaneously with Tca 8113 cells,and then were administrated with celecoxib,cisplatin or celecoxib combined with cisplatin respectively,and were sacrificed after 35 *** weight of xenograft was measured to calculate the tumor inhibition *** histological change was studied under light and electron *** COX-2 protein expression was observed by immunohistological *** the COX-2 mRNA expression was determined by ***:Celecoxib,the COX-2 inhibitor,could not only inhibit the growth of Tca8113 cell xenograft tumor and COX-2 protein expression,but also enhance the inhibitory effect cisplatin on xenograft tumor growth *** tumor inhibition rates of celecoxib group,cisplatin group and celecoxib plus cisplatin group were 15.63%,37.50% and 82.81% respectively that was statistically significant compared to control group(P < 0.01).The combined application of celecoxib and cisplatin could inhibit tumor growth more significantly than that of separated application(P < 0.01).The inhibitory effect of celecoxib on COX-2 mRNA expression of Tca 8113 cell was weaker and not significant(P = 0.073).Conclusion:Celecoxib can not only inhibit xenograft tumor growth in nude mice,but also enhance the inhibitory effect of CDDP on Tca 8113 transplanted tumor growth in nude *** mechanism maybe related to inhibition of COX-2 protein expression,which offers beneficial reference to further explore the mechanism between inhibition of COX-2 enzyme activity and prevention of head and neck tumor.

关键词： cyclooxygenase 2 celecoxib carcinoma squamous cell tongue neoplasms cisplatin

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Multiple distant metastasis of tongue squamous cell carcinoma after surgical operation and radiotherapy——a case report and literature review

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The Chinese-German Journal of Clinical Oncology 2010年第11期9卷 669-673页

作者： Weizhong Li Leitao Zhang Yu Huang Department of Oral and Maxillofacial Surgery Nanfang Hospital Southern Medical University Guangzhou 510515 China

This article reported a 36-year male patient with tongue squamous cell carcinoma who showed negative cervical lymphadenopathy by clinical examination but cervical lymph node metastases diagnosed by pathological examination. The patient underwent tongue tumor resection and left forearm radial skin flap repair, and then received 50 Gy 3-D conformal radiotherapy and chemotherapy combining 5-fluorouracil with carboplatin. One year after the operation, although the patient showed no tumor recurrence in primary site and no metastasis of cervical lymph nodes, metastasis occurred in several tissues including spine, ribs, mandible, skeletal muscles of upper extremity as well as lymph nodes of the mediastinum and lung hilum, which caused the patient to die quickly. According to the literature, we conclude that distant metastasis of tongue squamous cell carcinoma was less common, but once it occurs, the prognosis of the patient is extremely poor.

关键词： neoplasm metastasis carcinoma, squamous cell tongue neoplasms

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维普期刊数据库

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Early oral tongue cancer initially managed with surgery alone:Treatment of recurrence

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第4期2卷 -页

作者： Jeffrey C Liu Dennis S Sopka Ranee Mehra Miriam N Lango Christopher Fundakowski John A Ridge Thomas J Galloway Department of 0tolaryngology Temple University School of Medicine Philadelphia PA USA Department of Radiation 0ncology Fox Chase Cancer Center Philadelphia PA USA Medical 0ncology Fox Chase Cancer Center Philadelphia PA USA Head and Neck Surgery Fox Chase Cancer Center Philadelphia PA USA

Objective:To report T1-2N0 tongue cancer recurrences initially treated with sur-gery alone. Methods:Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent for locoregional recurrence after initial glossectomy with or without neck dissection for T1-2N0 tongue cancer. None had received adjuvant postopera-tive radiation as a component of the original treatment. Results:Median time to locoregional recurrence was 12 months (range 5e39 months) and 78%of failures occurred in the first 2 years. Most treatment failures were local (63%). Salvage strat-egy was risk-adapted by individual patient. The 5-year disease specific survival (DSS) was 61%. Patients with local recurrences alone fared significantly better than those with regional recur-rences (5-yr DSS:86%vs. 22%, P Z 0.0018). Local recurrences were usually treated by surgery alone, while regional recurrences were more commonly treated with combined modality treat-ment (PZ 0.005).Conclusions:Recurrence of early stage oral tongue cancer can be successfully salvaged in a majority of cases. Patients developing regional recurrence have significantly worse prognosis than those with local failures.

关键词： Oral cancer Head and neck cancer tongue neoplasms Salvage therapy

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