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Systematic Evaluation of Biyuan tongqiao Granule in the Treatment of Chronic Sinusitis in Children Based on Meta-analysis

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Medicinal Plant 2020年第1期11卷 1-6,16页

作者： Zhiyan HUANG Yongxia GUAN Qun FENG Guimin ZHANG Shili YE Jingchun YAO Lunan Pharmaceutical Group Co. Ltd.Linyi 276006China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006China Center for New Drug Pharmacology of Lunan Pharmaceutical Group Co. Ltd.Linyi 273400China

[Objectives]To make an evaluation of the efficacy and safety of Biyuan tongqiao Granule in the treatment of chronic sinusitis in children,and provide evidence-based medical reference for clinical use.[Methods]Databases such as Chinese Biomedical Literature Service System(SinoMed),China Knowledge Infrastructure(CNKI),Wanfang Digital Journal Full-text Database(WF),VIP Database(VIP),EmBase,PubMed,Science Direct,and Cochrane Library were used to collect the clinical randomized controlled trials of Biyuan tongqiao Granule in children with chronic sinusitis published since the creation of *** quality of the included literature was evaluated and the data were *** data was analyzed using Review Manager 5.3 software for meta-analysis,and descriptive analysis was performed for studies that could not be *** GRADE method was applied to evaluate the quality of evidence.[Results]A total of 12 studies were included,including 1645 cases of *** analysis results show that compared with the control group,Biyuan tongqiao Granule has an excellent curative effect on children with chronic sinusitis and has a lower incidence of adverse *** GRADE evidence level indicated that the sinus CT scan lesion score was intermediate evidence,and the visual analog score,endoscopic mucosal morphology score,and total effective rate were low-level evidence.[Conclusions]Biyuan tongqiao Granule has a significant effect in treating chronic sinusitis in children and does not increase the incidence of adverse reactions,but its efficacy and safety need support of more high-quality studies.

关键词： Biyuan tongqiao Granule Chronic sinusitis Randomized controlled trial Meta-analysis

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