检索结果-南通市图书馆

Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification

引用

Journal of Materials Science & Technology 2024年第1期168卷 250-264页

作者： Xiaotong Zhao Jiali Hu Jingjun Nie Dafu Chen Gaowu Qin Erlin Zhang Key Lab.for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing 100035China

Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical *** the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface *** superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the *** gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against ***),owing primarily to direct contact sterilization of Cu_(2)O/*** most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control *** coating extract also signifi-cantly stimulated in vitro angiogenesis *** rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO *** of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.

关键词： titanium-copper alloy titanium-nitride-oxide(TiNxOy) Cu^(2+)release Antibacterial property Cell compatibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

copper release and ROS in antibacterial activity of Ti-Cu alloys against implant-associated infection

引用

Rare Metals 2023年第6期42卷 2007-2019页

作者： Hai-Lin Yang Ling Zou Akram Nasser Juaim Chen-Xu Ma Meng-Zhen Zhu Fei Xu Xiao-Na Chen Yin-Zhou Wang Xiong-Wen Zhou State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Department of Prosthodontics Center of StomatologyXiangya HospitalCentral South UniversityChangsha410008China Department of Oral Implantology Xiangya Stomatological Hospital and Xiangya School of StomatologyCentral South UniversityChangsha410008China Department of Prosthodontics Faculty of DentistryThamar UniversityDhamarYM999101Yemen Center of Stomatology Xiangya HospitalCentral South UniversityChangsha410008China

Enhancing the antibacterial properties of the currently used implant materials is a major concern of healthcare providers to minimize the impact of peri-implant infection and improve implant survival *** this study,titanium-copper sintered alloys(3 wt% and 5 wt%Cu) were developed for medical implant *** phase identification,microstructure,copper ions release,and wettability of these alloys were evaluated using X-ray diffraction(XRD),optical microscope(OM),scanning electron microscope(SEM),transmission electron microscope(TEM),energy-dispersive X-ray spectroscope(EDS),inductively coupled plasma spectroscope(ICP) and drop shape *** antibacterial activities of Ti-Cu alloys against Porphyromonas gingivalis and Streptococcus mutans were evaluated using inhibition zone assay,plate counting assay,live/dead fluorescent staining,SEM and reactive oxygen species(ROS) staining *** results demonstrated that Ti-Cu alloys are composed of α-Ti and Ti_(2)Cu phases that increased with increased Cu content of the ***-Cu alloys exhibited antibacterial activity against both bacteria species in a time-dependent *** antibacterial rates of Ti-3Cu and Ti-5Cu after72 h were 57% and 70% against Porphyromonas gingivalis and 63% and 78% against Streptococcus mutans,*** highest amount of Cu^(2+) released from these alloys was 0.3 mg·L^(-1) during the first 24 h,within the safe *** copper ions release and ROS production were suggested as the main antibacterial ***,Ti-Cu sintered alloys are promising materials for dental and orthopedic implants.

关键词： titanium-copper alloy Antibacterial Dental implant Ti_(2)Cu copper release

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improvement in antibacterial ability and cell cytotoxicity of Ti-Cu alloy by anodic oxidation

引用

Rare Metals 2022年第2期41卷 594-609页

作者： Shuang Cao Zi-Ming Zhang Jia-Qi Zhang Ren-Xian Wang Xiao-Yan Wang Lei Yang Da-Fu Chen Gao-Wu Qin Er-Lin Zhang School of Materials Science and Engineering Key Laboratory for Anisotropy and Texture of MaterialsEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China School of Metallurgy Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloy has potential to be used in plastic surgery and dental implants due to its strong antibacterialproperties,high strength and good corrosion *** this paper,Ti-5Cu was anodic-oxidized to enhance the surface *** influence of the oxidation on the corrosion resistance,antibacterial properties and biological properties was investigated.X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results showed that a double-layer oxide coating with dense inner layer and porous outside layer was formed on Ti-Cu *** oxide coating consisted mainly of TiO2,CuzO and small amount of CuO,improved the corrosion resistance of Ti-Cu alloy by one order of magnitude due to the formation of the dense oxide inner layer,but high Cu ion release was *** plate count results showed that the antibac-terial activity of Ti-Cu sample was improved to≥99%due to the comprehensive function of CuO and Cu_(2)O in the coating and Cu^(2+)*** test results showed that thecoating exhibited good cell compatibility,the porous sur-face structure improved the adhesion of cells,and Cu ion release promoted the cell proliferation.

关键词： titanium-copper alloy Anodic oxidation Corrosion resistance Antibacterial activity Cell adhesion Surface modification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：