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surface activity of cancer cells:The fusion of two cell aggregates

BIOCELL 2023年第1期47卷 15-25页

作者： IVANA PAJIC-LIJAKOVIC MILAN MILIVOJEVIC Faculty of Technology and Metallurgy Belgrade UniversityBelgradeSerbia

A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the *** how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated,the impact of physical interactions on cell spreading remains less *** effects of physical interactions exist as the interplay between various physical parameters such as(1)tissue surface tension,(2)viscoelasticity caused by collective cell migration,and(3)solid stress accumulated in the cell aggregate core *** review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell *** epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension,which directs cell movement from the surface to the core region of two-aggregate systems,cancer cells rather perform surface cell *** cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly *** solid stress,accumulated in the core region of the two-aggregate system,is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition;however,this stress enhances the movement of cancer *** have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.

关键词： Collective cell migration tissue surface tension surface activity of cancer cells Viscoelasticity Solid stress The state of cell-cell adhesion contacts

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