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tissue response and the Cytoconduction Ability to Collagen/Hydroxyapatite Heterotopic Implantation

Journal of Huazhong University of Science and Technology(Medical Sciences) 1997年第2期17卷 118-122页

作者：夏志道朱通伯杜靖远汪岚 Department of Orthopedics Xiehe Hospital Tongji Medical University Wuhan

A histological and ultrastructural observation of CHA implanted intra-muscularly and subcutaneously had been reported- Our results showed that a mildinflammation developed at the early stage and disappeared 2 weeks after implanta-tion. The infiltrating cells were mainly monocyte-macrophages, a number of fi-broblasts followed macrophags closely. It was possible that as CHA degrades,monocyte - mac rop hages continuouslyre leased inflammatory factors, thus enhanc-ing fibroblast proliferation activity and tissue regeneration. In addition, the het-erotopic calcification of collagen matrix was observed, suggesting that CHA prthmoted calcification deposition.

关键词： collagen/hydroxyapatite tissue response cytoconduction

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Retrobulbar administration of purified anti-nerve growth factor in developing rats induces structural and biochemical changes in the retina and cornea

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 209-216页

作者： Luigi Aloe Maria Luisa Rocco Bijorn Omar Balzamino Graziana Esposito Alessandra Micera Institute of Cell Biology and Neurobiology CNRLazio 00143RomeItaly Fondazione IRET Ozzano EmiliaBologna 40064Italy Institute of Translational Pharmacology CNRLazio 00133RomeItaly Research and Development Laboratory for Biochemical Molecular and Cellular Applications in Ophthalmological ScienceIRCCSFondazione BiettiRome 00182Italy

AIM:To develop an experimental model of endogenous nerve growth factor(NGF)deprivation by retrobulbar administration of purified neutralizing anti-NGF antibodies in young Sprague-Dawley rats and provide further information on NGF expression in the retina and cornea.METHODS:Sixty old pathogen-free Sprague Dawley rats(p14,post-natal days)were treated with repeated retrobulbar injections of neutralizing anti-NGF(2μL,100μg/m L,every 3 d).After 2 wk(p28),retinal and corneal tissues were investigated for morphological,biochemical,and molecular expression of trkANGFR by using Western blotting or immunofluorescence.Rhodopsin as well as protein profile expression were also investigated.RESULTS:Chronic retrobulbar neutralizing anti-NGF antibodies changed the distribution of trkANGFR immunoreactivity at retinal level,while no changes were detected for global trkANGFR protein expression.By contrary,the treatment resulted in the increase of corneal trkANGFR expression.Retinal tissues showed a decreased rhodopsin expression as well as reduced number of both rhodopsin expressing and total retinal cells,as observed after single cell extraction.A decreased expression of ICAM-1,IL-17 and IL-13 as well as an increased expression of IL-21 typified retinal extracts.No significant changes were observed for corneal tissues.CONCLUSION:The reduced availability of endogenous NGF,as produced by chronic retrobulbar anti-NGF administration,produce a quick response from retinal tissues,with respect to corneal ones,suggesting the presence of early compensatory mechanisms to protect retinal networking.

关键词： anti-nerve growth factor trk^(ANGFR) retina cornea photoreceptors tissue response

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High nitrogen stainless steel drug-eluting stent-Assessment of pharmacokinetics and preclinical safety in vivo

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Bioactive Materials 2020年第4期5卷 779-786页

作者： Shanshan Chen Zhifeng Yao Yongbiao Guan Hui Yang M.Babar Shahzad Yizhe Wu Bingchun Zhang Li Shen Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China Shanghai Institute of Cardiovascular Diseases Department of CardiologyZhongshan HospitalFudan University180 Fenglin RoadShanghai200032China National Beijing Center for Drug Safety Evaluation and Research Beijing Institute of Pharmacology and ToxicologyAcademy of Military Medical Sciences27 Taiping RoadHaidian DistrictBeijing100850People's Republic of China

Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation,while one sirolimus-eluting stent was implanted into one of their coronary artery.At different time points,the residual sirolimus on the stent,delivered locally(to artery wall),regionally(to adjacent and downstream muscle)and systemically(to plasma and visceral organs),was detected throughout 120 days.Preclinical safety evaluation was performed using 32 pigs for 180-days implantation to study the safety of metal platform material and the effectiveness of sirolimus eluting coating on the HNS stent.The neointima area,restenosis rate and inflammatory grade for HNS and control group stents were detected and analyzed.Approximately 80%sirolimus was eluted from the sirolimuseluting stents after 30-days implantation in vivo.Additionally,there was sustained sirolimus in the artery wall,cardiac muscle and heart throughout 120-days implantation,and sirolimus accumulated to the peak at 90-days implantation.It was inferred that the sirolimus eluting stent in this study was covered by neointima before 90-days implantation,indicating that the sirolimus eluting coating on the HNS stent was safe and effective.Very little sirolimus was distributed in visceral organs after 14-days implantation.HNS sirolimus-eluting stent exhibited lower restenosis rate and lower inflammatory grade than control group,which verified that the sirolimus-eluting coating design in this study was reasonable and practical.In addition,there were no significant difference in restenosis rate and inflammatory score between HNS bare-metal stent and drug-eluting stents,illustrating that HNS has good bio-compatibility and is suitable to use as coronary artery stent material.

关键词： Sirolimus-eluting stent Pharmacokinetics Preclinical safety tissue response

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