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Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

World Journal of Gastroenterology 2014年第15期20卷 4128-4140页

作者： Bhavna Rani Yuan Cao Andrea Malfettone Ciprian Tomuleasa Isabel Fabregat Gianluigi Giannelli Department of Medical Biosciences and Human Oncology Padiglione Semeiotica Medica70124 BariItaly Bellvitge Biomedical Research Institute (IDIBELL) 08028 BarcelonaSpain Department of Hematology Center for Genomics and Translational MedicineIuliu Hatieganu University of Medicine and Pharmacy400012 Cluj NapocaRomania Department of Physiological Sciences Ⅱ University of Barcelona08028 BarcelonaSpain

Hepatocellular carcinoma is difficult to treat,primarilybecause the underlying molecular mechanisms drivingclinical outcome are still poorly *** suggests that the tissue microenvironmenthas a role in the biological behavior of the *** clinical issue is to identify the best target fortherapeutic ***,we discuss the hypothesis that the entire tissue microenvironment might beconsidered as a biological ***,the tissuemicroenvironment consists of several cellular and biochemical components,each of which displays a distinctbiological *** discuss the major components ofthis environment and consider how they may interactto promote tumor/host crosstalk.

关键词： tissue microenvironment Hepatocellular carcinoma Transforming growth factor-beta Laminin-5 Cancer stem cells Therapy Target therapy

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Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

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Regenerative Biomaterials 2022年第1期9卷 202-218页

作者： Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Medical Technology and Related Equipment Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityShunde DistrictFoshanP.R.China

Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue *** jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine ***,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound ***,treatment efficacy was significantly compromised in diabetic ***,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic *** research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing ***-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic ***,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关键词： autologous regeneration factors wound healing homeostasis tissue microenvironment inflammation patterning

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Matricellular proteins: multifaceted extracellular regulators in tumor dormancy

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Protein & Cell 2014年第4期5卷 249-252页

作者： Tiantian Wu Gaoliang Ouyang State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Biology School of Life Sciences Xiamen University

Tightly controlled extracellular matrix (ECM) homeostasis and remodeling is critical for normal organ homeostasis,wound healing and tissue ***,excessive or uncontrolled ECM deposition contributes to aberrant homeostasis of tissue microenvironment in various inflammatory diseases and *** proteins are a set of structurally unrelated ECM proteins that do not exert a primary role in tissue architecture but have regulatory roles in embryonic development,tissue injury,inflammation and tumor *** recent studies demonstrated that matricellular proteins in the ECM surrounding dormant tumor cells may determine the fate of tumor cells to remain quiescent or undergo metastatic *** identification of matricellular proteins in regulating ECM homeostasis and remodeling specific organ niches during tumor dormancy may provide potential novel extracellular targets for the development of therapeutic interventions against tumor dormancy.

关键词： Acute Lymphoblastic Leukemia tissue microenvironment Matricellular Protein Metastatic Growth Tumor Dormancy

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