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Roles of the fibroblast growth factor signal transduction system in tissue injury repair

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Burns & Trauma 2022年第1期10卷 618-638页

作者： Keyang Chen Zhiheng Rao Siyang Dong Yajing Chen Xulan Wang Yongde Luo Fanghua Gong Xiaokun Li School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of breast surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Research Units of Clinical Translation of Cell Growth Factors and Diseases Research Chinese Academy of Medical ScienceWenzhou Medical UniversityWenzhouZhejiang 325000China

Following injury,tissue autonomously initiates a complex repair process,resulting in either partial recovery or regeneration of tissue architecture and function in most organisms.Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors,cytokines and other signaling molecules under normal conditions.However,under chronic traumatic or pathological conditions,the reparative or regenerative process of most tissues in different organs can lose control to different extents,leading to random,incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function,accompanied by the development of fibrosis,scarring or even pathogenesis that could cause organ failure and death of the organism.Ample evidence suggests that the various combinatorial fibroblast growth factor(FGF)and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis.In this review,we attempt to provide a brief update on our current understanding of the roles,the underlying mechanisms and clinical application of FGFs in tissue injury repair.

关键词： tissue injury Repair Regeneration Cell growth Fibroblast growth factor Signal transduction

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

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Bioactive Materials 2019年第1期4卷 160-166页

作者： Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang Rehabilitation Medicine Department PLA General HospitalBeijing100853China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics&ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China School of Chemistry and Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Orthopedic Research Institute The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology GuangzhouChina

Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury.

关键词： Hydrogel Magnetism-responsive tissue injury Tetra-PEG/agar

'Repair' Treg cells in tissue injury

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'Repair' Treg cells in Tissue Injury

Expression of inducible nitric oxide synthase in the brain tissue of rats at preoxygenation, hypoxia/reoxygenation

第十二届全国免疫学学术大会

作者： li lifeng Zhang Chaoqi Kexin Feng Daoyang Fan Wenhua Xue Jingli Lu Biotherapy Center The First Affiliated Hospital of Zhengzhou University Department of Oncology The First Affiliated Hospital of Zhengzhou University Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Department of Orthopedics Peking University Third Hospital

Studies in mice and humans have elucidated an import role for Tregs in promoting tissue repair and restoring tissue integrity.There is growing evidence that Tregs are present in some injured tissues with distinct phenotypical and functional diversity;these local Tregs function as a traditional modulator by limiting local immune responses,as well as act as a nontraditional role with capacity to exert self-derived pro-repair factors that contribute to parenchymal cellular repair.In this review,we provide an overview of the emerging knowledge about the Treg-mediated repair in damaged tissues and organs,with a particular focus on Tregs resident in local tissues;we also discuss the central role of Treg-derived prorepair factors and how they are modulated in the context of injury.

关键词： Treg cells tissue injury repair

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Neural Regeneration Research 2006年第8期1卷 689-692页

作者： Hongzhi Chen Lu Li Hong Zhao Department of Anesthesiology Shengjing Hospital China Medical University Shenyang 110004 Liaoning ProvinceChina Department of AnesthesiologyShengjing Hospital China Medical University Shenyang 110004 Liaoning ProvinceChina Department of AnesthesiologyShengjing Hospital China Medical University Shenyang 110004 Liaoning ProvinceChina

BACKGROUND: The disorder of the respiratory and circulation system during the anesthesia and operation often can lead to severe hypoxia. Preoxygenation is a conventional therapy for treatment of hypoxia. OBJECTIVE: To observe the change in the expression of inducible nitric oxide synthase(iNOS), i.e. brain tissue injury degree, in cerebral cortex of rats after hypoxia/reoxygenation under the condition of different levels of preoxygenation. DESIGN: Randomized controlled animal experiment. SETTING: Department of Anesthesiology and Central Laboratory, Shengjing Hospital Affiliated to China Medical University. MATERIALS: This experiment was carried out in the laboratory of Shengjing Hospital Affiliated to China Medical University from March 2003 to March 2004. Seventy-two male Wistar rats, weighing from 250 to 300 g, were provided by the Animal Experimental Room of Shengjing Hospital of China Medical University [License No. SYXK (Liao) 2003-0019]. Seventy-two rats were randomized into 3 groups: preoxygenation group, hypoxia group and reoxygentation group. Each group was divided into 4 subgroups, 6 rats in each subgroup. METHODS: 0.21, 0.50, 0.75 and 0.98 volume fraction of oxygen was given to 4 subgroups of preoxygenation group respectively. The rats in each subgroup of hypoxia group inhaled oxygen for 30 minutes according to the method of preoxygenation. Then, nitrogen gas replaced oxygen and was pumped into the cabin, and the volume fraction of oxygen was decreased to be 0.05 within 20 minutes. The rats in each subgroup of reoxygenation group were treated with the experimental methods of preoxygenation and hypoxia separately, then they were moved into the wide mouthed bottle with two-air-duct rubber stopper. Finally, oxygen was pumped and the volume fraction of oxygen reached over 0.98 within 20 minutes. After 24 hours, all the surviving rats were killed by decapitation. Cerebral tissue was sliced and stained by haematoxylin-eosin and then enveloped. Brain tissue injury was observed by pathohistological method. The

关键词： volume fraction tissue injury nitric oxide synthase animal experiment result analysis neuronal injury cerebral cortex brain injury Wistar rats methods of method of

Damage control:Harnessing prostaglandin E2 as a potential healing factor of tissue injuries

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Genes & Diseases 2015年第4期2卷 295-298页

作者： Connie Shao Christine Shen Emily Lu Rex C.Haydon Hue H.Luu Aravind Athiviraham Tong-Chuan He Michael J.Lee The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA College of Liberal Arts and Sciences University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Increasing prostaglandin E2 by knocking out its inhibitor 15-hydroxyprostaglandin dehydrogenase(15-PDGH)or administering a compound that inhibits 15-PDGH was recently found to improve healing in hematopoietic stem cell transplants,colitis recovery,and hepatogenesis after transection in mice.These results are suggestive of pharmacologic therapies or even genetic therapy that could improve patient outcomes,especially since the excess PGE2 and the 15-PDGH inhibitor have proven to be non-toxic.However,elevated levels of PGE2 are associated with increased risk of cancer and blood clotting problems.It would be unacceptable to treat a cancer patient with chemotherapy and replenish the hematopoietic stem cells with the help of PGE2,only to have increased expression of PGE2 and induce another cancer.Therefore,to assess the most therapeutic aspects of PGE2,it is important to consider effects that could induce disease.

关键词： Cancer COX activity Prostaglandin E2 tissue injury tissue regeneration

PROTEIN KINASES AND CENTRAL SENSITIZATION OF SPINAL DORSAL HORN NEURONS:CENTRAL MECHANISMS OF PAIN

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皖南医学院学报 2003年第Z1期22卷 20-21页

作者： QING LIN Department of Anatomy & Neurosciences and Marine Biomedical Institute University of Texas Medical Branch301 University Blvd. GalvestonTexas 77555-1069U.S.A.

　　The enhanced responsiveness of spinal dorsal horn neurons, including spinothalamic tract (STT) cells, that follows peripheral tissue injury or inflammation is thought to underlie the development of secondary hyperalgesia and allodynia and is referred to as "central sensitization" because the increases in excitability do not appear to depend on continued activity of peripheral nociceptors.……

关键词： dorsal horn neurons tissue injury