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Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing

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Bioactive Materials 2021年第11期6卷 3692-3704页

作者： Xin Zhang Ying Li Zhijie Ma Dan He Haiyan Li School of Biomedical Engineering Shanghai Jiao Tong University1954 Huashan RoadShanghai200030China Chemical1nd Environmental Engineering School of EngineeringRMIT University124 La Trobe StMelbourneVIC3000Australia

More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate,which impedes tissue ***,hydrogels with macropores and/or controlled degradation attract more and more attention for solving this *** alginate/Bioglass(SA/BG)hydrogel,which has been reported to be an injectable and bioactive hydrogel,is also limited to be used as tissue engineering scaffolds due to its nanosized ***,in this study,degradation of SA/BG hydrogel was modulated by grafting deferoxamine(DFO)to *** functionalized grafted DFO-SA(G-DFO-SA)was used to form G-DFO-SA/BG injectable *** vitro degradation experiments proved that,compared to SA/BG hydrogel,G-DFO-SA/BG hydrogel had a faster mass loss and structural *** the hydrogels were implanted subcutaneously,G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG *** addition,in a rat full-thickness skin defect model,wound healing studies showed that,G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels ***,G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation,which suggesting a promising application potential in tissue regeneration.

关键词： Sodium alginate Bioglass Hydrogels degradation tissue infiltration Wound healing

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