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tissue distribution of [^3H]—Nicotine in Rats

Biomedical and Environmental Sciences 1993年第1期6卷 59-64页

作者： PARIMALCHOWDHURY RYUICHIRODOIPHILLIPL.RAYFORD LOUISW.CHANG Departments DepartmentsDepartments of Physiology BiopgysicsToxicologyUniversity of Arkansas for Medical Sciences4301W.Markham StLittle RockA R 72205USAof Physiology and BiophysicsUniversity of Arkansan for Medical Sciences4301W.Markham StLittle RockA R 72205USAof Physiology and ToxicologyUniversity of Arkansas for Medical Sciences4301W.Markham StLittle RockA R 72205USA

This study was conducted in adult male Sprague -- Dawley rats to determine the distribution of [3H]-nicotine in blood and tissues following a bolus injection and a constant infusion of pure nicotine. The animals were anesthetized and injected with either 0.5 ml of nicotine solution or given a constant infusion of the same nicotine solution with identical amounts of radioactive nicotine. After sacrifice, blood, brain, trachea, salivery gland, esophagus, lung, heart, liver, fundus, antrum, spleen, pancreas, duodenum, jejunum, ileum, cecum, colon, kidneys, adrenal gland, and testes were collected and measured for radioactivity by scintillation counting. The distribution of nicotine was found highest in kidneys by both routes of administration. Higher accumulations were also found in salivary and adrenal glands, fundus, antrum, duodenum, jejunum, ileum and colon. Retention of nicotine via constant infusion was significantly higher in esophagus, fundus antrum, spleen, cecum, pancreas, testes, heart and muscle when compared with bolus injection. Six-fold increase in retention of blood levels of nicotine were found with constant infusion. (Ptissues such as esophagus, fundus, antrum, spleen, cecum, pancreas, testes, heart and muscle via constant exposure. These data may implicate the predisposition of these tissues to pathologic manifestations.

关键词： tissue distribution of Nicotine in Rats

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