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Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma

World Journal of Gastroenterology 2014年第35期20卷 12581-12587页

作者： Masayoshi Yada Akihide Masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita Hideo Suzuki Takeshi Senju Toshimasa Koyanagi Department of Hepatology Iizuka Hospital

AIM: To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma (HCC).

关键词： Hand-foot syndrome Hepatocellular carcinoma Indicator of efficacy Sorafenib time to progression

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Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib

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World Journal of Gastroenterology 2021年第47期27卷 8166-8181页

作者： Ajalaya Teyateeti Armeen Mahvash James Long Mohamed Abdelsalam Rony Avritscher Ahmed Kaseb Bruno Odisio Gregory Ravizzini Devaki Surasi Achiraya Teyateeti Homer Macapinlac Srinivas Cheenu Kappadath Department of Nuclear Medicine The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Division of Nuclear Medicine Department of RadiologyFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Department of Interventional Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Biostatistics The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Division of Radiation Oncology Department of RadiologyFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Impressive survival outcome of our previous study in unresectable hepatocellular carcinoma(HCC)patients undergoing yttrium-90 glass microspheres transarterial radioembolization(TARE)with/without sorafenib according to individuals’disease burden,i.e.,intrahepatic tumor load(IHT)and adverse disease features(ADFs)might partly be confounded by other treatments and underlying hepatic ***,a dedicated study focusing on treatment response and assessment of failure patterns might be a way to improve treatment outcome in addition to patient selection based on the disease *** To assess the tumor response,disease control and patterns of disease progression following TARE with/without sorafenib in unresectable HCC *** This retrospective study was conducted in successful TARE procedures with available pre-and post-treatment imaging studies(n=169).Three treatment subgroups were(1)TARE only(TARE_alone)for IHT≤50%without ADFs,i.e.,macrovascular invasion,extrahepatic disease(EHD)and infiltrative/ill-defined HCC(n=63);(2)TARE with sorafenib(TARE_sorafenib)for IHT>50%and/or presence of ADFs(n=81);and(3)TARE only for patients who could not receive sorafenib due to contraindication or intolerance(TARE_no_sorafenib)(n=25).Objective response rate(ORR;consisted of complete response(CR)and partial response(PR)),disease control rate(DCR;consisted of CR,PR and stable disease)and failure patterns of treated,intrahepatic and extrahepatic sites were assessed using the modified response evaluation criteria in solid *** to progression(TTP)was calculated from TARE to the first radiologic progression at any site using Kaplan-Meier *** of prognostic factors for TTP using the univariate Kaplan-Meier method and multivariate Cox proportional hazard model were performed in major population subgroups,TARE_alone and TARE_*** The median radiologic follow-up time was 4.4 mo(range 0.5-48.8).In treated area,ORR was highest in

关键词： Radioembolization Selective internal radiotherapy Tumor response Pattern of progression time to progression Sorafenib

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