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The Effect of Xu’s Influenza Decoction Combined with Oseltamivir on Influenza A:A Propensity Score Matching Study

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 1-9页

作者： Tianxi Chen Shuyan Fu Fengyuan Tian Qiushuang Li Hongyu Ling Yijie Lou Jun Tang Hong Zheng Basic Medical School Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Department of Infectious Diseases First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Center of Clinical Evaluation and Analysis First Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou 31006ZhejiangChina Department of General Practice First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina

Background:The resurgence of seasonal influenza virus circulation has been seen in 2021-2022 after the tempo-rary suppression in *** inhibitors(NAIs)are widely applied in the clinical treatment of influenza A despite several ***:To access the efficacy of Xu’s influenza decoction(XID)in combination therapy with oseltamivir for the treatment of influenza ***:In this retrospective cohort study,the eligible participants were diagnosed with influenza A between June 1,2018,and May 30,2022,in the First Affiliated Hospital of Zhejiang Chinese Medical *** to whether Xu’s influenza decoction was applied,patients were divided into two groups:treated with or without *** score matching(PSM)was used to further adjust the covariates between *** primary outcome was to compare time to defervescence via K-M curves,Breslow tests,and cox regression *** cox proportional hazards model,a univariate analysis was performed to obtain preliminary results,while a further multivariate analysis was conducted to study the independent factors that influence *** analysis was conducted according to body temperature and time from onset to *** secondary outcome consisted of routine blood and C-reactive protein(CRP),length of stay,and medical ***:A total of 336 patients with influenza A were enrolled in this study(i.e.,163 patients in the XID+oseltamivir group;173 patients in the oseltamivir group).After 1:1 matching via PSM,230 patients meeting the criteria were included in the analysis,with 115 in each *** XID+oseltamivir group had shorter time to defervescence(36 h vs 44 h,P=0.011),shorter length of stay(3 days vs 4 days,P=0.018),and higher defervescence possibility(HR=1.384,95%CI:1.054-1.818).Subgroup analysis indicated that for patients during non-window period(≥48 h)with medium-grade fever(38.1℃-39℃),the XID+oseltamivir combination therapy reduced time to defervescence

关键词： Influenza A Xu’s influenza decoction Oseltamivir time to defervescence,cox regression Propensity score matching Cohort study

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