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Synergistic antibacterial activity of physical-chemical multi-mechanism by tio2 nanorod arrays for safe biofilm eradication on implant

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Bioactive Materials 2021年第1期6卷 12-25页

作者： Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu Laboratory of Biomaterial Surfaces&Interfaces Institute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan030024China College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China Second Hospital of Shanxi Medical University Taiyuan030024China Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the *** multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the *** this work,tio2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of *** tio2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in *** importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the tio2 nanorod arrays improve the new bone formation around *** this protocol,besides the biocompatible tio2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be *** findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second *** concept and antibacterial system described here have large clinical potential in orthopedic and dental applications.

关键词： Titanium implants tio2 nanorod Anti-biofilm Physical insertion Light-triggered therapy

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Effect of hydroxyl on dye-sensitized solar cells assembled with tio_2 nanorods

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Chinese Physics B 2018年第1期27卷 75-79页

作者：孟立建杨涛云斯宁李灿 Functional Materials Laboratory School of Materials & Mineral Resources Xi'an University of Architecture and Technology Departamento de Física and Centre of Innovation in Engineering and Industrial Technology Instituto Superior de Engenharia do PortoInstituto Politécnico do Porto Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

YiO2 nanorods have been prepared on ITO substrates by dc reactive magnetron sputtering technique. The hydroxyl groups have been introduced on the nanorods surface. The structure and the optical properties of these nanorods have been studied. The dye-sensitized solar cells （DSSCs） have been assembled using these tio2 nanorods as photoelectrode. And the effect of the hydroxyl groups on the properties of the photoelectric conversion of the DSSCs has been studied.

关键词： hydroxyl groups tio2 nanorod dye-sensitized solar cells sputtering

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