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Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy pain:A randomized controlled trial

Journal of Integrative Medicine 2023年第2期21卷 168-175页

作者： Xin-rui Han Wei Yue Hui-chao Chen Wei He Jiang-he Luo Shan-xia Chen Na Liu Ming Yang Department of Nursing Chengdu Integrated TCM&Western Medicine HospitalSichuan 610041Sichuan ProvinceChina School of Nursing Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Nursing Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of General Surgery Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Gynecology and Obstetrics Guangzhou Women and Children’s Medical CenterGuangzhou 510120Guangdong ProvinceChina

Background Treatment duration of wrist-ankle acupuncture(WAA)is uncertain for post-thyroidectomy pain *** This study evaluated the effect of different WAA treatment duration on post-operative pain relief and other discomforts associated with ***,setting,participants and intervention This randomized controlled trial was conducted at a single research site in Guangzhou,China.A total of 132 patients receiving thyroidectomy were randomly divided into the control group(sham WAA,30 min)and three intervention groups(group 1:WAA,30 min;group 2:WAA,45 min;group 3:WAA,60 min),with group allocation ratio of 1:1:1:*** was administered within 1 hour of leaving the operating *** and measures Primary outcome was patients’pain at the surgical site assessed by visual analogue scale(VAS)at the moment after acupuncture treatment(post-intervention).Secondary outcomes included the patients’pain VAS scores at 6,12,24,48 and 72 h after the thyroidectomy,the 40-item Quality of Recovery(QoR-40)score,the grade of post-operative nausea and vomiting(PONV),and the use of additional analgesic *** The adjusted mean difference(AMD)in VAS scores from baseline to post-intervention in group 1 was-0.89(95%confidence interval[CI],-1.02 to-0.76).The decrease in VAS score at post-intervention was statistically significant in group 1 compared to the control group(AMD,-0.43;95%CI,-0.58 to-0.28;P<0.001),and in groups 2 and 3 compared to group 1(group 2 vs group 1:AMD,-0.65;95%CI,-0.81 to-0.48;P<0.001;group 3 vs group 1:AMD,-0.66;95%CI,-0.86 to-0.47;P<0.001).The VAS scores in the four groups converged beyond 24 h after the *** patients in group 2 and group 3 experienced PONV in the first 24 h after *** statistical differences were measured in QoR-40 score and the number of patients with additional analgesic *** Compared with the 30 min intervention,WAA treatment with longer needle retention time(45 or 60 min)had

关键词： thyroidectomy thyroid tumor Wrist-ankle acupuncture Post-operative pain Randomized controlled trial

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Papillary thyroid carcinoma occurring with undifferentiated pleomorphic sarcoma: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8336-8343页

作者： Yu-Li Lee Ya-Qiong Cheng Chen-Fang Zhu Hai-Zhong Huo Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Papillary thyroid cancer(PTC)is the most common malignant tumor of the ***,the coexistence of PTC and sarcoma in one patient is *** this article,we report the case of a patient who presented with both PTC and undifferentiated pleomorphic sarcoma(UPS),which has not been previously reported in the online Medline database(PubMed).CASE SUMMARY A 71-year-old man was admitted to our hospital for a mass on the right side of his neck for one month,which rapidly enlarged within 2 wk with distending *** patient was diagnosed with a thyroid malignancy by fine-needle aspiration and underwent total thyroidectomy and bilateral central lymph node *** and immunohistochemistry revealed features of both PTC and *** thyroid cancer 8 gene detection kit results showed BRAF and telomerase reverse transcriptase *** disease progressed rapidly,and the patient died four months after surgery from extensive lung *** Our report highlights the patient’s pathological characteristics and related genetic *** to the rapid development and poor prognosis of cooccurring PTC and sarcoma,it is important for clinical physicians and pathologists to raise awareness of this type of tumor.

关键词： thyroid tumor Papillary thyroid carcinoma Undifferentiated pleomorphic sarcoma BRAF TERT Case report

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Review： Deregulation of microRNA expression in thyroid tumors

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第3期15卷 212-224页

作者： Zi-ming YUAN Zhi-li YANG Qi ZHENG Department of General Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 China

MicroRNAs （miRNAs or miRs） are endogenous non-coding RNAs that negatively regulate gene expres- sion by binding to the 3＇ non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expres- sion profiles, single nucleotide polymorphism （SNP） in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.

关键词： MicroRNA Target gene thyroid tumor Single nucleotide polymorphism (SNP) Somatic mutation

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Treatment Outcome of Papillary Carcinoma Confined to the thyroid Isthmus

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Journal of Cancer Therapy 2016年第12期7卷 963-969页

作者： Hui Huang Shao-Yan Liu Song Ni Zong-Min Zhang Xiao-Lei Wang Zhen-Gang Xu Department of Head and Neck Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China

Objective: The purpose of this study is to evaluate the clinicopathologic characteristics and treatment outcomes of Papillary thyroid Carcinomas (PTC) of the isthmus and to establish an appropriate surgical strategy. Methods: Thirty-four patients with PTC in isthmus are managed by surgery in National Cancer Center/Cancer Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College from 1985-2008. Demographic data, surgical procedures, pathological features, stages and outcomes are analyzed. Results: Seven patients were men and 27 were women. The median age was 41 years (range, 20 - 71). Twenty-five patients were treated with thyroid isthmusectomy or wide field isthmusectomy, five with hemithyroidectomy (lobectomy and isthmusectomy) and four with hemithyroidectomy and partial resection of the contralateral lobe. Twenty-eight patients had a pathologically T1 lesion (pT1);two patients had a pT2 lesion and four had a pT3 lesion. Five patients (14.7%) had papillary carcinoma detected in one of the pretracheal lymph nodes. Thirty-two patients had a solitary lesion confined to the thyroid isthmus. One patient had two lesions in the thyroid isthmus and another one had two lesions located in the thyroid isthmus and right lobe respectively. With a median follow-up of 94 months (range, 12 - 274), two patients had a recurrence and both survived after a re-operation. There was no regional lymph node or distant organ recurrences. No deaths occurred. Conclusions: Isthmusectomy or wide field isthmusectomy could be a sufficient treatment for PTC confined to the thyroid isthmus. We also recommend that pretracheal lymph node dissection be considered.

关键词： thyroid tumor Isthmus of thyroid Papillary Carcinoma Surgery

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隐匿性甲状腺癌的淋巴结及血行转移

隐匿性甲状腺癌的淋巴结及血行转移

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2000国际暨第六届全国头颈肿瘤外科学术会议

作者：叶真秦建武魏林河南省肿瘤医院头颈科河南省肿瘤医院头颈科河南省肿瘤医院头颈科

＜正＞目的:探讨隐匿性甲状腺癌淋巴结及血行转移规律。方法:对62例隐匿性甲状腺癌的临床资料进行回顾性分析。结果:颈淋巴结转移38例,转移率为61．3％,血行转移3例,转移率为4．8％。提示转移与病理类型及肿瘤局部浸润程度有关,与原发... 详细信息

＜正＞目的:探讨隐匿性甲状腺癌淋巴结及血行转移规律。方法:对62例隐匿性甲状腺癌的临床资料进行回顾性分析。结果:颈淋巴结转移38例,转移率为61．3％,血行转移3例,转移率为4．8％。提示转移与病理类型及肿瘤局部浸润程度有关,与原发灶大小无关。结论:认为隐匿性甲状腺癌生物学特性与其同类型的甲状腺癌相符合,治疗应分别遵从同类型甲状腺癌的治疗原则。

关键词： thyroid tumor lymphoidnode blood metastasis

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