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Middle thyroid vein tumor thrombus in metastatic papillary thyroid microcarcinoma:A case report and review of literature

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World Journal of Clinical Cases 2022年第10期10卷 3213-3221页

作者： Yan Gui Jun-Yi Wang Xu-Dong Wei Department of Otorhinolaryngology Head and Neck Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of thyroid and Neck Tumor Key Laboratory of Cancer Prevention and Therapy of TianjinTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of Otorhinolaryngology Head and Neck Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Although papillary thyroid microcarcinoma(PTMC)is not considered a threatening tumor,in some cases,it can be *** thrombosis of papillary thyroid carcinoma,follicular thyroid carcinoma,Hürthle cell carcinoma,poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma have been reported in the literature,but there have been no reports about *** SUMMARY A 45-year-old woman presented with a thyroid mass and thrombosis in a middle thyroid vein during a physical *** had no symptoms,and the physical examination showed no positive *** ultrasonographyguided fine-needle aspiration biopsy results indicated an atypical lesion of ambiguous significance,with some actively growing cells(TBSRTCⅢ)and the BRAFV600E mutation not *** patient underwent left thyroidectomy,isthmus lobectomy,prophylactic central lymph node dissection and *** pathology showed papillary microcarcinoma of the left thyroid,and the thrombus in the middle thyroid vein was a tumor *** Middle thyroid vein tumor thrombus is an extremely rare condition in PTMC,but it does *** and thromboembolectomy may be an option for patients with thrombi in the middle vein of the thyroid,and we strongly suggest close follow-up of these patients.

关键词： thyroid neoplasms Papillary carcinoma thyroid vein Venous thrombosis Surgery Case report

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Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts Antitumor Activities against Growth of thyroid Cancer

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Chinese Medical Journal 2016年第13期129卷 1544-1552页

作者： Bing-Feng Chu Yi-Yu Qin Sheng-Lai Zhang Zhi-Wei Quan Ming.Di Zhang Jian-Wei Bi Graduate School Shanghai Second Military Medical University Shanghai 200433 China Department of General Surgery Xinhua Hospita/Affiliated to Shanghai Jiao Tong Univeisity School of Medicine Shanghai 200092 China Clinical College Yancheng Institute of Health Sciences Yancheng Jiangsu 224000 China Department of First General Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China

Background： The Notch-regulated ankyrin repeat protein （NRARP） is recently found to promote proliferation of breast cancer cells. The role of NRARP in carcinogenesis deserves extensive investigations. This study attempted to investigate the expression of NRARP in thyroid cancer tissues and assess the influence of NRARP on cell proliferation, apoptosis, cell cycle, and invasion in thyroid cancer. Methods： Thirty-four cases with thyroid cancer were collected from the Department of General Surgery, Xinhua Hospital, Shanghai ]iao Tong University School of Medicine between 2011 and 2012. lmmunohistochemistry was used to detect the level of N RARP in cancer tissues. Lentivirus carrying NRARP-shRNA （Lenti-NRARP-shRNA） was applied to down-regulate NRARP expression. Cell viability was tested after treatment with Lenti-NRARP-shRNA using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay. Apoptosis and cell cycle distribution were determined by flow cytometry. Cell invasion was tested using Transwell invasion assay. In addition, expressions of several cell cycle-associated and apoptosis-associated proteins were examined using Western blotting after transfection. Student＇s t-test, one-way analysis of variance （ANOVA）, or Kaplan Meier were used to analyze the differences between two group or three groups. Results： N RARP was highly expressed in thyroid cancer tissues. Lenti-NRARP-shRNA showed significantly inhibitory activities against cell growth at a multiplicity of infection of l 0 or higher （P 〈 0.05）. Lenti-NRARP-shRNA-induced G 1 arrest （BHTl 01 ： 72.57% ± 5.32%; g305C： 75.45% ± 5.26%） by promoting p21 expression, induced apoptosis by promoting bax expression and suppressing bcl-2 expression, and inhibited cell invasion by suppressing matrix metalloproteinase-9 expression. Conclusion： Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyro

关键词： Apoptosis Cell Cycle Checkpoints Notch-regulated Ankyrin Repeat Protein thyroid neoplasms

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Stem cell biology in thyroid cancer: Insights for novel therapies

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World Journal of Stem Cells 2014年第5期6卷 614-619页

作者： Parisha Bhatia Koji Tsumagari Zakaria Y Abd Elmageed Paul Friedlander Joseph F Buell Emad Kandil Departments of Surgery Tulane University School of Medicine New Orleans LA 70112 United States Departments of Otolaryngology Tulane University School of Medicine New Orleans LA 70112 United States

Currently, thyroid cancer is one of the most common endocrine cancer in the United States. A recent involvement of sub-population of stem cells, cancer stem cells, has been proposed in different histological types of thyroid cancer. Because of their ability of self-renewal and differentiation into various specialized cells in the body, these putative cells drive tumor genesis, metastatic activity and are responsible to provide chemo- and radioresistant nature to the cancer cells in the thyroid gland. Our Review was conducted from previously published literature to provide latest apprises to investigate the role of embryonic, somatic and cancer stem cells, and discusses the hypothesis of epithelial-mesenchymal transition. Different methods for their identification and isolation through stemness markers using various in vivo and in vitro methods such as flow cytometry, thyrosphere formation assay, aldehyde dehydrogenase activity and ATP-binding cassette sub-family G member 2 efflux-pump mediated Hoechst 33342 dye exclusion have been discussed. The review also outlines various setbacks that still remain to target these tumor initiating cells. Future perspectives of therapeutic strategies and their potential to treat advanced stages of thyroid cancer are also disclosed in this review.

关键词： Stem cells Cancer Stem cells thyroid neoplasms Carcinogenesis Cell Differentiation Epithelial-Mesenchymal transition

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The clinical management of Level VI lymph node and neck lymph node micrometastases in follicular thyroid carcinoma

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The Chinese-German Journal of Clinical Oncology 2010年第7期9卷 378-380页

作者： Qinjiang Liu Hengping Li Youxin Tian Department of Head and Neck Surgery The Cancer Hospital of Gansu Province Lanzhou 730050 China

Objective： We evaluated the relationship between the clinical management of level Ⅵ lymph node and neck lymph node micrometastases in follicular thyroid carcinoma. Methods： 326 negative neck lymph nodes of 68 cases with follicular thyroid carcinoma on routine pathology were examined by keratin-19 monoclonal antibody and S-P JmmunohJsto- chemistry to confirm lymph node micrometastasis. Follow-up pathological and clinical documents were compared. Results： Forty-six neck lymph nodes showed positive micrometastasis among 326 negative neck lymph nodes including 4 lymph nodes in Level Ⅱ （4/42）, 5 lymph nodes in Level Ⅲ （5/34）, 5 lymph nodes in Level Ⅳ （5/49）, 1 lymph node in Leve Ⅳ （1/17） and 31 lymph nodes in Level Ⅳ （31/184）. Six in 14 cases with positive micrometastasis showed distant metastasis or local recurrence, but only 3 in 54 cases with negative micrometastasis indicated distant metastasis or local recurrence （P 〈 0.01）. Conclusion： The research showed that Level VI neck lymph node micrometastasis is possibly occur and closely related with local recurrence and metastasis in follicular carcinoma of thyroid.

关键词： thyroid neoplasms lymphatic metastasis micrometastasis, Immunohistochemistry

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thyroid fine needle aspiration

Thyroid fine needle aspiration

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2013年

作者： Grace C. H. Yang.

ISBN: (纸本)9781107022201

This practical text and color atlas tells the story of 350 patients, covering a wide range of thyroid lesions with high quality composite images that correlate cytology with histology, and radiology with pathology. Each case includes clinical presentation and final pathology. Concise, easy-to-read text enables readers to quickly find the information they need for accurate diagnosis. 'Lookalike' le

关键词： thyroid gland Diseases Cytodiagnosis. thyroid gland Needle biopsy. thyroid neoplasms diagnosis. Biopsy, Fine-Needle methods. thyroid Gland pathology.

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Socioeconomic inequalities in cancer incidence and mortality:An analysis of GLOBOCAN 2022

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Chinese Medical Journal 2024年第12期137卷 1407-1413页

作者： Wei Cao Kang Qin Feng Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Hangzhou Center for Disease Control and Prevention HangzhouZhejiang 310021China The Third People’s Hospital of Xiaoshan HangzhouZhejiang 311251China

Background:Given the recent updates in cancer burden estimates by GLOBOCAN 2022,this study was undertaken to provide pertinent perspectives within the context of the Human Development Index(HDI)and major world ***:Datasets sourced from GLOBOCAN encompassed cancer cases and deaths across all cancer types in 2022,alongside projections up to *** incidences and deaths of the top 10 cancers within China and four distinct HDI-classified regions were compared using descriptive ***-standardized incidence rates(ASIRs)and mortality rates(ASMRs)worldwide for the most prevalent cancers in 2022 across ten largest economies and four-tier HDIs were *** top five cancer types concerning both incidence and mortality in China were delineated by sex and age ***:In males,prostate cancer predominated in countries with low,high(except China),and very high *** and liver cancers were prominent causes of death in countries with low *** females,breast and cervical cancers predominated in countries with low-to-medium *** and colorectal cancer incidence and deaths increased with high HDI for both *** and ASMRs for breast,prostate,lung,and colorectal cancers in the top 10 economies were higher than the global ***,liver,stomach,and cervical cancers in most Western countries exhibited lower *** China,hematologic malignancies(43%)were prevalent among children aged 0-14 years,whereas thyroid cancer led among adolescents and young adults aged 15-39 *** incidence and mortality,lung cancer predominated for individuals over 40 years,except for females aged 40-59 years,in whom breast cancer *** trends indicated substantial increases in new cancer cases(76.6%)and deaths(89.7%)over the next three ***:Infection-and poverty-related cancer burdens are offset by increased prostate,breast,colorectal,and lung cancer incidence associated with rapid societal and economic transi

关键词： Incidence Mortality Tumor burden China Human Development Index Hematologic neoplasms Lung neoplasms Breast neoplasms Colorectal neoplasms thyroid neoplasms Liver neoplasms Prostatic neoplasms Early detection of cancer

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