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Cytokines predict virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy

World Journal of Clinical Cases 2020年第11期8卷 2255-2265页

作者： Wen-Kang Fu Jie Cao Ning-Ning Mi Chong-Fei Huang Long Gao Jin-Duo Zhang Ping Yue Bing Bai Yan-Yan Lin Wen-Bo Meng The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Laboratory Department of the First Hospital of Lanzhou University Lanzhou 730000Gansu ProvinceChina Special Minimally Invasive Surgery Department The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Genetics School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Hepatopancreatobiliary of Gansu Province Lanzhou 730000Gansu ProvinceChinao Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province Lanzhou 730000Gansu ProvinceChina

BACKGROUND Chronic hepatitis B virus infection remains a major global public health ***-alpha-2a(PEG-IFN)has direct antiviral and immunoregulatory effects,and it has become one of the first choice drugs for the treatment of chronic hepatitis B(CHB).Cytokines play an important role in immunity,and they directly inhibit viral replication and indirectly determine the predominant pattern of the host immune *** To determine the correlation between cytokine/chemokine expression levels and response to PEG-IFN treatment in patients with *** Forty-six kinds of cytokines were analyzed before PEG-IFN therapy and at 24 wk during therapy in 26 CHB *** The monokine induced by INF-γ(CXCL9)and serum interferon-inducible protein 10(IP-10)levels at baseline were higher in virological responders than in nonvirological responders(NRs)and decreased during treatment,whereas the NRs did not exhibit significant *** macrophage inflammatory protein 1d(MIP-1d)levels at baseline and during treatment were significantly higher in the virological responders than in the NRs,while thymus and activation-regulated chemokine(TARC)levels at baseline and during treatment were significantly lower in the virological responders than in the *** CXCL9,IP-10,MIP-1d,and TARC baseline levels exhibited the expected effects for interferon *** area under the receiver operating characteristic curve values of CXCL9,IP-10,MIP-1d,and TARC for predicting virological responses were 0.787,0.799,0.787,and 0.77(P=0.01,0.013,0.01,and 0.021),*** We found that cytokine levels before and during treatment may represent potential biomarkers to select CHB patients who can respond to ***,cytokines can be used as an indicator of antiviral drug selection before CHB treatment.

关键词： Chronic hepatitis B Peginterferon-alpha-2a Cytokine/chemokine CXCL9 Interferon-inducible protein 10 thymus and activation-regulated chemokine

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Study of pruritus in chronic hepatitis C patients

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World Journal of Gastroenterology 2014年第47期20卷 17877-17882页

作者： Kazuyoshi Suzuki Masaya Tamano Yasumi Katayama Toru Kuniyoshi Kagemasa Kagawa Hiroshi Takada Kazutomo Suzuki Department of Gastroenterology Dokkyo Medical University Koshigaya HospitalSaitama 343-8555Japan

AIM: To investigate the occurrence and severity of pruritus in chronic hepatitis C patients treated with or without interferon (IFN) therapy.

关键词： Hepatitis C Pruritus Peginterferon Ribavirin thymus and activation-regulated chemokine

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