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Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle

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Journal of Integrative Medicine 2022年第5期20卷 463-472页

作者： Asmita Pal Sucharita Das Soumalee Basu Rita Kundu Department of Botany University of CalcuttaKolkataWest Bengal 700019India Department of Microbiology University of CalcuttaKolkataWest Bengal 700019India

Objective‘Multi-targeting’drugs can prove fruitful to combat drug-resistance of multifactorial disease—cervical *** study envisioned to reveal if Thuja homeopathic mother tincture(MT)and its bioactive component could combat human papillomavirus(HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated *** Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species(ROS)generation by 2’,7’-dichlorodihydrofluorescein diacetate(DCFDA)staining and loss in mitochondrial membrane potential(MMP)by rhodamine(Rh)123 *** and autophagy inductions were studied by acridine orange(AO)ethidium bromide(EB)staining and immunoblot analyses of marker *** bioactive component of Thuja MT detected by gas chromatography-mass spectrometry was studied for antiproliferative and antimigratory properties along with in silico prediction of its cellular targets by molecular docking and oral drug forming *** Thuja MT showed significant antiproliferative and antimigratory potential in SiHa cells at a 50%inhibitory concentration(IC50)dosage of 17.3μL/*** increase in DCFDA fluorescence and loss in Rh123 fluorescence prove that Thuja MT acted through the burst of ROS and loss in MMP ***/EB-stained cells under the microscope and immunoblot analyses supported Thuja-induced cellular demise via dual pathways—apoptosis and *** showed cleavage of caspase-3 and poly adenosine diphosphate-ribose polymerase-1(PARP-1)along with upregulation of Beclin-1,microtubule-associated protein 1 light chain 3B(LC3B)-II,and p62 ***,the apoptotic cascade followed a caspase-3-dependent pathway supported by PARP-1 cleavage,while autophagic death was Beclin-1-dependent and mediated by accumulation of LC3BII and p62 ***,detected as the bioactive principle of Thuja MT showed greater anti-pro

关键词： Thuja Homeopathy thujone Cervical cancer Apoptosis-autophagy crosstalk

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Variation in the Composition of the Essential Oil of Commercial Salvia officinalis *** Samples from Different Countries

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2051-2062页

作者： Ain Raal Anne Orav Tetiana Ilina Alla Kovalyova Taras Koliadzhyn Yuliia Avidzba Oleh Koshovyi Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia Institute of Chemistry Tallinn University of TechnologyTallinn12618Estonia The Department of Pharmaceutical Management Drug Technology and PharmacognosyIvano-Frankivsk National Medical UniversityIvano-Frankivsk76018Ukraine The Department of Pharmacognosy National University of PharmacyKharkiv61002Ukraine The Department of Clinical Laboratory Diagnostics Kharkiv National Medical UniversityKharkiv61022Ukraine

Salvia officinalis L.(Lamiaceae)leaves and its essential oil is used for mouth and throat disorders,skin disorders,minor wounds,and gastrointestinal disorders,and is widely used *** research aimed to conduct a comparative study of the composition of *** essential oils from commercial samples,and their main *** volatile constituents from *** leaves were investigated using gas chromatography(GC).The commercial samples of sage leaves were obtained from retail pharmacies in nine mainly European *** yield of essential oil in *** commercial leaves was between 10.0 and 24.8 mL/*** principal components(>5%)among the main identified 25 compounds were 1,8-cineole(8.3%–45.3%),α-thujone(3.0%–34.0%),сamphor(11.3%–29.3%),β-thujone(1.5%–12.9%),viridiflorol(1.1%–10.4%),camphene(2.6%–7.1%),andα-pinene(1.3%–5.8%).In seven(Estonia,England,France,Hungary,Belgium,Ukraine,Georgia)samplesα-thujone *** samples(Estonia,Georgia,England,Hungary)belong to the most common chemotypeα-thujone>camphor>1,*** chemotypes of *** essential oils have been *** thujones are widespread compounds among them.

关键词： Sage terpenoids chemotypes thujone toxicity

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Essential Oil Composition of Artemisia scoparia Waldst. &Kitag from Qinghai-Tibetan Plateau of China

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Journal of Analytical Sciences, Methods and Instrumentation 2016年第1期6卷 1-5页

作者： Lihong Yao Haibo Bo Chemistry Department of Qinghai Normal University Xining China

The oils extracted by hydro distillation from the aerial parts of Artemisia scoparia waldst. & kitag growing wild in two regions on Qinghai-Tibetan Plateau were analyzed by GC-MS. Eighty-three components were identified representing 97.5% of the total components detected. The major constituents of the oil from the samples obtained in the eastern of Riyue Mountain (2700 - 3200 m) were 2-ethenyl-naphthalene (45.1%), beta-pinene (11.2%), 3-carene (8.7%), 3,7-dimethyl-1,3,6- octatriene (7.9%), limonene (5.4%), alpha-pinene (3.5%) and beta-myrcene (2.0%). Whereas the oil from the plant collected in Qilian Mountain (3300 - 3500 m) was composed mainly of thujone (21.4%), 1,8-cineole (18.9%), camphor (9.1%), 4-methyl-1-(1-methyl ethyl)-3-cyclo hexen-1-ol (7.8%), 4-methyl-1-(1-methylethyl)-bicyclo[3.1.0]hexan-3-one (5.3%) and 2-isopropyl-5-methyl- 3-cyclohexen-1-one(5.0%).

关键词： Artemisia scoparia Waldst. & Kitag Essential Oil 1 8-Cineole thujone 2-Ethenyl-Naphthalene Beta-Pinene

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Essential oil composition of Artemisia scoparia waidst.& kitag from Qinghai-Tibetan Plateau of China

Essential oil composition of Artemisia scoparia waidst.& kit...

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西北地区第五届色谱学术报告会暨甘肃省第十届色谱年会

作者：薄海波 Qinghai Entry-Exit Inspection and Quarantine Bureau

The oils extracted by hydrodistillation from the aerial parts of Artemisia scoparia waldst.& kitag growing wild in two regions on Qinghai-Tibetan Plateau were analyzed by ***-four components were identified representing 97.5% of the total components *** major constituents of the oil from the samples obtained in the eastern of Riyue Mountain (2700-3200 m) were 2-ethenyl-naphthalene (45.1%),beta-pinene (11.2%),3-carene (8.7%),3,7-dimethyl-1,3,6-octatriene (7.9%), limonene (5.4%),alpha-pinene (3.5%) and beta-myrcene (2.0%),Whereas the oil from the plant collected in Qilian Mountain (3300-3500 m) was composed mainly of thujone (21.4%), 1,8-cineole (18.9%),camphor (9.1%), 4-methyl-1-(1-methyl ethyl)-3-cyclohexen-1-ol (7.8%),4-methyl-1-(1-methylethyl)-bicyclo[3.1 .0]hexan-3-one(5.3%)and2-isopropyl-5- methyl-3-cyclohexen-1-one(5.0%).

关键词： Artemisia scoparia waldst.& kitag essential oil GC-MS 1,8-cineole thujone 2-ethenyl-naphthalene beta-pinene

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