检索结果-南通市图书馆

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022年第3期16卷 416-428页

作者： Jiansong Huang Xin Huang Yang Li Xia Li Jinghan Wang Fenglin Li Xiao Yan Huanping Wang Yungui Wang Xiangjie Lin Jifang Tu Daqiang He Wenle Ye Min Yang Jie Jin Department of Hematology Key Laboratory of Hematologic MalignanciesDiagnosis and TreatmentThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Hematology Zhejiang University School of MedicineHangzhou 310003China Department of Obstetrics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hematology Qingdao Municipal HospitalQingdao 266000China Department of Laboratory Medicine Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China Cancer Center Zhejiang UniversityHangzhou 310058China

Abivertinib,a third-generation tyrosine kinase inhibitor,is originally designed to target epidermal growth factor receptor(EGFR)-activating *** studies have shown that abivertinib has promising antitumor activity and a well-tolerated safety profile in patients with non-small-cell lung ***,abivertinib also exhibited high inhibitory activity against Bruton’s tyrosine kinase and Janus kinase *** that these kinases play some roles in the progression of megakaryopoiesis,we speculate that abivertinib can affect megakaryocyte(MK)differentiation and platelet *** treated cord blood CD34+hematopoietic stem cells,Meg-01 cells,and C57BL/6 mice with abivertinib and observed megakaryopoiesis to determine the biological effect of abivertinib on MK differentiation and platelet *** in vitro results showed that abivertinib impaired the CFU-MK formation,proliferation of CD34+HSC-derived MK progenitor cells,and differentiation and functions of MKs and inhibited Meg-01-derived MK *** results suggested that megakaryopoiesis was inhibited by *** also demonstrated in vivo that abivertinib decreased the number of MKs in bone marrow and platelet counts in mice,which suggested that thrombopoiesis was also ***,these preclinical data collectively suggested that abivertinib could inhibit MK differentiation and platelet biogenesis and might be an agent for thrombocythemia.

关键词： abivertinib Btk inhibitor platelet megakaryocyte megakaryopoiesis thrombopoiesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model

引用

Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 720-724页

作者： Sinhalagoda Lekamlage chandi Asoka Dharmarathna Susiji Wickramasinghe Roshitha Nilmini Waduge Rajapakse Peramune Veddikkarage Jayanthe Rajapakse Senanayake Abeysinghe Mudiyanselage Kularatne Department of Pathobiology Faculty of Veterinary Medicine and Animal ScienceUniversity of Peradeniya Department of Parasitology Faculty of MedicineUniversity of Peradeniya Department of Pathology Faculty of MedicineUniversity of Peradeniya Department of Medicine Faculty of MedicineUniversity of Peradeniya

Objective:To investigate the potential role of fresh Carica papaya(***)leaf extract on haematological and biochemical parameters and toxicological changes in a murine ***:In total 36 mice were used for the *** *** leaf extract[0.2 mL(2 g)/mouse]was given only to the test group(18 mice).General behavior,clinical signs and feeding patterns were *** and tissue samples were collected at *** parameters including platelet,red blood cell(RBC),white blood cell<(WBC),packed cell volume(PCV),serum biochemistry including serum creatinine,serum glutamic-oxaloacetic transaminase(SCOT)and serum glutamic-pyruvic transaminase(SGPT)were *** for possible histopathological changes were ***:Neither group exhibited alteration of behavior or reduction in food and water ***,no significant changes in SCOT,SGPT and serum creatinine levels were delected in the test *** organ changes were not observed in either group of mice except in three liver samples of the test group which had a mild focal *** platelet count(11.33±0.35)×10~5VμL(P=0.00004)and the RBC count(7.97±0.61)×10~/μL(P=0.00003)were significandy increased in the test group compared to that of the ***,WBC count and PCV(%)values were not changed significantly in the test *** platelet count in the test group started to increase significantly from Day 3(3.4±0.18×10~5/μL),reaching almost a fourfold higher at Day 21(11.3×10~5/μL),while it was 3.8X10^5/μL and 5.5×10~5/μL at Day 3 and Day 21 respectively in the ***,the RBC count in the test group increased from 6×10~6/μL to 9×10~6/μL at Day 21 while it remained near constant in the control group(6×10~6μL).Conclusions:Fresh *** leaf extract significandy increased the platelet and RBC counts in the test group as compared to ***,it is very important to identify those chemicals of *** leaves as it can be recomme

关键词： Carica papaya Alternative medicine Erythropoiesis thrombopoiesis Toxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stem cell autotomy and niche interaction in different systems

引用

World Journal of Stem Cells 2015年第6期7卷 922-944页

作者： David C Dorn August Dorn Department of Hematology HemostasisOncologyand Stem Cell TransplantationHannover Medical School Institute of Zoology Johannes Gutenberg University

The best known cases of cell autotomy are the formation of erythrocytes and thrombocytes(platelets) from progenitor cells that reside in special niches. Recently, autotomy of stem cells and its enigmatic interaction with the niche has been reported from male germline stem cells(GSCs) in several insect species. First described in lepidopterans, the silkmoth, followed by the gipsy moth and consecutively in hemipterans, foremost the milkweed bug. In both, moths and the milkweed bug, GSCs form finger-like projections toward the niche, the apical cells(homologs of the hub cells in Drosophila). Whereas in the milkweed bug the projection terminals remain at the surface of the niche cells, in the gipsy moth they protrude deeply into the singular niche cell. In both cases, the projections undergo serial retrograde fragmentation with progressing signs of autophagy. In the gipsy moth, the autotomized vesicles are phagocytized and digested by the niche cell. In the milkweed bug the autotomized vesicles accumulate at the niche surface and disintegrate. Autotomy and sprouting of new projections appears to occur continuously. The significance of the GSC-niche interactions, however, remains enigmatic. Our concept on the signaling relationship between stem cell-niche in general and GSC and niche(hub cells and cyst stem cells) in particular has been greatly shaped by Drosophila melanogaster. In comparing the interactions of GSCs with their niche in Drosophila with those in species exhibiting GSC autotomy it is obvious that additional or alternative modes of stem cell-niche communication exist. Thus, essential signaling pathways, including niche-stem cell adhesion(E-cadherin) and the direction of asymmetrical GSC division- as they were found in Drosophila- can hardly be translated into the systems where GSC autotomywas reported. It is shown here that the serial autotomy of GSC projections shows remarkable similarities with Wallerian axonal destruction, developmental axon pruning and d

关键词： Stem cell-niche interaction Male germlinestem cells Spermatogenesis Erythropoiesis Stem cellautotomy thrombopoiesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：