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Si-Miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway

Chinese Journal of Natural Medicines 2024年第6期22卷 541-553页

作者： CHU Chu SUN Shangwen ZHANG Zhen WU Qi LI Haoyang LIANG Gang MIAO Xiuming JIANG Haiqiang GAO Yan ZHANG Yunhong WANG Bin LI Xia Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remod-eling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJinan 271016China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014China International Business School Tianjin Foreign Studies UniversityTianjin 300204China Institute of Pharmaceutical Research Shandong University of Traditional Chinese MedicineJinan 250355China

thromboangiitis obliterans(TAO)is a rare,chronic,progressive,and segmental inflammatory disease characterized by a high rate of amputation,significantly compromising the quality of life of ***-Miao-Yong-An decoction(SMYA),a tradition-al prescription,exhibits anti-inflammatory,anti-thrombotic,and various other pharmacological ***,it was fully proved to be effective for TAO therapy,but the specific therapeutic effect of SMYA on TAO has been ***,deep unveiling the mechanism of SMYA in TAO for identifying clinical therapeutic targets is extremely *** this study,we observed elev-ated levels of IL-17A in the peripheral blood mononuclear cells(PBMCs)of TAO patients,whereas the expression of miR-548j-5p was significantly decreased.A negative correlation between the levels of miR-548j-5p and IL-17A was also *** vitro ex-periments showed that overexpression of miR-548j-5p led to a decrease in IL-17A levels,whereas downregulation of miR-548j-5p showed the opposite *** a dual luciferase assay,we confirmed that miR-548j-5p directly targets ***,serum containing SMYA effectively decreased IL-17A levels by increasing the expression of *** importantly,the results of in vivo tests indicated that SMYA mitigated the development of TAO by inhibiting IL-17A through the upregulation of miR-548j-5p in vascular *** conclusion,SMYA significantly enhances the expression of miR-548j-5p,thereby reducing the levels of the target gene IL-17A and alleviating *** research not only identifies novel targets and pathways for the clinical diagnosis and treatment of TAO but also advances the innovation in traditional Chinese medicine through the elucidation of the SMYA/miR-548j-5p/IL-17A regulatory axis in the pathogenesis of TAO.

关键词： thromboangiitis obliterans IL-17A Inflammation miR-548j-5p Si-Miao-Yong-An Decoction

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Integrated treatment for lower-limb stage Ⅱ thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial

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Journal of Traditional Chinese Medicine 2015年第1期35卷 41-46页

作者： Chang Yaowen Li Fenqiang Wang Wenhui Song Laichang Li Li Li Zhengfei Su Dongjun Fu Zhaoliang Department of Integrated Chinese and Western Medicine with Interventional Therapy the First Affiliated Hospital of Lanzhou University Department of Integrated Chinese and Western Medicine Gansu University of Traditional Chinese Medicine

OBJECTIVE： To observe if integrated treatment is better than other therapies for lower-limb stage Ⅱ thromboangiitis obliterans （TAO）. METHODS： Ninety lower-limb stage Ⅱ or worse TAO patients were randomly divided into three groups： group A （30 cases） treated by intervention and oral administration of Chinese medicine; group B （30 cases） treated by intervention alone; and group C （30 cases） treated only with oral adminis- tration of Chinese medicine. Therapeutic effects were observed, including the cure rate; the recurrence rate after one month, three months, six months, nine months, and one year; the ankle brachial indexes; the incidence of complications; and the level of C-reactive protein and erythrocyte sedimentation ***： Group A had significantly better clinically curative effects, related indexes, and outcomes during the long-term follow-up survey, than that of groups B and C. CONCLUSION： Integrated treatment is more effective for treating lower-limb stage Ⅱ or worseTAO.

关键词： thromboangiitis obliterans Lower ex-tremity Intervention studies Medicine, Chinese traditional Treatment outcome Randomized controlled trials

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TCM Treatment of thromboangiitis obliterans—A Report of 64 Cases

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Journal of Traditional Chinese Medicine 2005年第1期25卷 34-36,页

作者：门军章门九章王薇 The 5th People's Hospital DatongShanxi 037004China Shanxi College of Traditional Chinese Medicine Taiyuan 030024

thromboangiitis obliterans (TAO), a common peripheral vascular disease with a long illness course and grave sufferings, can cause acromelic gangrene, ulcer and even amputation at the late stage. We have for many years used TCM syndrome differentiation to diagnose and treat the disease with good therapeutic results. The treatment of 64 TAO cases from 2001 to 2002 is reported as follows.

关键词： Phytotherapy Adolescent Adult Diagnosis, Differential Drugs, Chinese Herbal Female Humans Male Medicine, Chinese Traditional Middle Aged thromboangiitis obliterans Treatment Outcome

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Vacuum-compression therapy for ischemic disease of the extremities:experience with 40 patients

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Journal of Pharmaceutical Analysis 2009年第3期21卷 206-208页

作者： Ya-bin Qi1,Guang-yu Qi2,Qing-yong Ma21. Department of General Surgery,Xi’an Railway Central Hospital,Xi’an 710054 2. Department of General Surgery,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061,China. Department of General Surgery Xi'an Railway Central Hospital Xi'an 710054 China Department of General Surgery First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China

Objective To study the clinical effects of vacuum-compression therapy for ischemic disease of the extremities. Methods A total of 40 cases of peripheral arterial disorders,including 23 thromboangiitis obliterans (31 limbs) and 17 arteriosclerosis obliterans (23 limbs),were treated by a self-made vacuum-compression therapeutic apparatus. Results The effective rate in thromboangiitis obliterans and arteriosclerosis obliterans groups was 96.77% and 92.23%,respectively. The cuffs on the apparatus were improved to eliminate discomfort in the patients during treatment. "Rebound symptom" was observed during treatment,which had not been reported previously. Conclusion Vacuum-compression therapy has a good prospect for treating ischemia of the extremities.

关键词： vacuum-compression therapy thromboangiitis obliterans arteriosclerosis obliterans

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Treating Principles and Methods of Traditional Chinese Medicine in Treatment of Peripheral Vascular Diseases

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Journal of Traditional Chinese Medicine 2001年第2期21卷 130-133页

作者：张雅洁陈知行刘玉洁张雅琳 ~1Qiqihaer Municipal TCM Hospital Heilongjiang province161000 ~2Qiqihaer Second Hospital Heilongjiang province

Peripheral vascular disease embraces a variety of conditions such as thromboangiitis obliterans, Raynaud's disease, thrombophlebitis, aorto-arteritis, obliterate atherosclerosis, varix or phlebothrombosis of the lower limb. Although the affected blood vessel may be arterial or venous one and caused either by inflammation or degenerate changes, they share common symptoms and signs, such as blood stasis, ischemia, thrombosis, ecchymosis, swelling, constriction or obliteration of blood vessels due to circulatory impairment. Since they share common characteristics, the treating principles and methods will be discussed as follows.

关键词： Diagnosis, Differential Drugs, Chinese Herbal Female Humans Male Medicine, Chinese Traditional Raynaud Disease thromboangiitis obliterans Thrombophlebitis

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