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Clinical evaluation of HPV DNA test combined with liquid-based cytology in the diagnosis of cervical disease

Open Journal of Obstetrics and Gynecology 2013年第3期3卷 371-376页

作者： Raghvendra Thakur Jasma Mally Rajina Shrestha Xuehua Zheng Mengli Zhang Yanjun Wu Neelima Bajracharya Guiying Zheng Department of Obstetrics and Gynecology First Hospital of Jilin University Norman Bethune College of Medicine Changchun China Department of Obstetrics and Gynecology Jiamusi University Jiamusi China Department of Obstetrics and Gynecology Maternity and Children Hospital of Jilin Province Liaoyuan China Department of Obstetrics and Gynecology Second Hospital of Jilin University Norman Bethune College of Medicine Changchun China

Objectives: To evaluate the sensitivity and accuracy of the HPV DNA test in conjunction with thin prep cytology test as a screening method of human papillomavirus (HPV) infection. To study either the cervical erosion is related to high risk HPV infection or to determine the mean age distribution that is more prone to HPV infection. Material and Methods: The study is a retrospective cohort implemented to determine the real performance of liquid based medium and HPV DNA testing combined in second clinical hospital of Jilin University Changchun, China. The study group included total 150 patients from January 1, 2011 to December 30, 2012. A computerized search identified patients with thin prep test results and high risk HPV DNA testing during a 2-year period was recruited. The patients were chosen after proper speculum examination followed by thin prep cytology (TCT) and HPV DNA test. Cytologic specimens were obtained with endocervical brush, which was rinsed into the vial of Cytyc. The residual samples after the cytology report were taken for reflex HPV DNA test. The manufacture protocol was followed for HPV DNA testing using Hybrid Capture II. Colposcopic biopsy was performed for the diagnosis purpose, in patients who had atypical squamous cells of undeter-mined significance (AUS-US), low grade intraepithelial lesion (LSIL) or high-grade intraepithelial lesion (HSIL) in cytology and with positive results of highrisk HPV DNA. The diagnostic criteria were based on the Bethesda System (TBS). Findings: The high risk HPV positive women with abnormal cytology had a CIN I risk of 73 (86%), whereas 35 (23.3%) high-risk HPV positive women out of 109 (72.7%) normal cytology who underwent histological biopsy had CIN I 16 (10.7%). The risk for cervical intraepithelial neoplasia (CIN) in women with high-risk HPV positive with normal cytology was higher among women invited for the first time 31 - 40 years of age 12 (8%) than among older women 1 (0.7%). Out of 44 (29.3%) women who

关键词： Human Papillomavirus thin-prep Cytology Test Hybrid Capture Cervical Intraepithelial Neoplasia Bethesda System Colposcopy Examination

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