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Wells’syndrome possibly caused by hematologic malignancy,influenza vaccination or ibrutinib:A case report

World Journal of Clinical Cases 2022年第30期10卷 10997-11003页

作者： Mihela Šajn Boštjan Luzar Samo Zver Department of Hematology University Medical Centre LjubljanaLjubljana 1000Slovenia Institute of Pathology Medical Faculty LjubljanaLjubljana 1000Slovenia Medical Faculty University of LjubljanaLjubljana 1000Slovenia

BACKGROUND Wells’ syndrome(eosinophilic cellulitis) is an uncommon eosinophilic dermatosis of uncertain pathogenesis,characterized by clinical polymorphism and suggestive but nonspecific histopathologic *** course is recurrent,and response to therapy is *** a case in which the patient has a number of potential triggers for the manifestation of Wells’ syndrome skin rash,the treating physician must decide or must make an assumption in order to establish the most likely clinical *** is important for the patient’s future treatment *** SUMMARY We describe the clinical case of a 46-year-old female with chronic lymphocytic leukemia who had already received treatment for several months with *** was diagnosed with Wells’ syndrome 10 d after an influenza vaccination containing *** on the literature,the patient was treated with a course of oral *** of clinical symptoms and rash were observed in response to the *** was not *** The etiology of Wells’ syndrome remains ***,it resembles bacterial *** of response to antibiotic treatment should lead the physician to consider a diagnosis of Wells’ *** the underlying condition is important and may lead to resolution of the ***,the most common and effective treatment to limit the course of the disease are systemic steroids.

关键词： Wells’syndrome Chronic lymphocytic leukemia Allogenic hematopoietic stem cell transplantation Ibrutinib thimerosal-containing influenza vaccine Clinical case Case report

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