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Cell Signaling in Viral and Oncogenic Pathogenesis and Its Implications in Disease Diagnosis and Prognosis

中山大学学报（医学科学版） 2010年第2期31卷 141-153页

作者： LI Meng-feng Department of Microbiology∥Ministry of Education Key Laboratory of Tropical Diseases Control Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China

Both viral diseases and cancer account for a large proportion of serious health problems. Viral infection and cancer are biologically and medically correlated and in many ways share common cellular pathways that lead to disease development or progression. Better understanding how these signaling events are specifically activated by different pathogenic stimuli and how they activate different downstream transcriptions in response to these stimuli at high specificity and efficiency will provide a new molecular basis for the development of novel disease biomarkers and therapeutic or preventive targets against both classes of diseases. Research in our laboratory has been prompted to investigate the regulation and modes of action of these pathways, with a more intensive focus on the NF-κB signaling, in the settings of severe or oncogenic viral infection as well as cancer development. It is hoped that our research will lead to eventual clinical application of biomarkers derived from these signaling pathways.

关键词： Viral infection NF-κB, oncogenesis biomarkers therapeutic targets

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Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target

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Journal of Cancer Metastasis and Treatment 2019年第3期4卷 108-130页

作者： Massimo Monks Foivos Irakleidis Peng H.Tan UCL Medical School Faculty of Medical ScienceRoyal Free NHS Foundation HospitalLondon NW32QGUK Breast Unit Department of SurgeryRoyal Free NHS Foundation TrustLondon NW32QGUK

Obesity has the far reaching consequence on cancer pathogenesis and immune reactions.In particular,adiponectin(APN)produced by adipocytes played an important role in modulating obesity related malignancies.Via its interaction with corresponding receptors and their downstream signalling pathways,it regulates cells survival,apoptosis and cancer metastasis.Our review dissects the clinical evidence on how hypoadiponectinaemia associated with the increased risks of several cancers and the long-term prognosis and also addresses the controversies.APN also has its indirect effect on anti-cancer immune response which may influence the disease process.We also analyse the impact of APN on the immune system,the anti-tumour responses and the controversies surrounding this area.Targeting therapeutics on APN and its receptor axis represents a promising and novel anti-cancer treatment.Biological understanding of how APN and its interaction with its receptors may affect the immune reactivity.Careful strategizing the use of APN therapeutics in cancer treatment is important,as the APN receptor signalling on the immune cells can blunt anti-tumour response.Targeting APN or its receptors has an enormous implication for the treatment of cancers.

关键词： Adiponectin AdipoR1/R2 Cancer signaling pathway anti-tumor immunity therapeutic targets

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Cellular and molecular mechanisms implicated in pathogenesis of selective neurodegeneration in Huntington＇s disease

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Frontiers of physics 2012年第5期7卷 459-476页

作者： Jeffrey R CANTLE Center for Neurobehavioral Genetics Semel Institute for Neuroscience & Human Behavior David Geffen School of Medicine at UCLA_ University of California Los Angeles CA 90095 USA DepartmentofPsychiatry & Biobehavioral Sciences David Geffen School of Medicine at UCLA University of California Los Angeles CA 90095 USA Brain Research Institute. David Geffen School of Medicine at UCLA University of California Los Angeles CA 90095 USA Interdepartmental Program for Neuroscience David Geffen School of Medicine at UCLA University of CaliJbrnia Los Angeles CA 90095 USA

Huntington＇s disease （HD） is one of the most common dominantly-inherited neurodegenerative disorders and is caused by a CAG repeat expansion in the huntingtin gene. HD is characterized by selective degeneration of subpopulations of neurons in the brain, however the precise underlying mechanisms how a ubiquitously expressed disease protein could target specific types of neurons for degeneration remains a critical, yet unanswered question for HD and other major neurodegenerative disorders. In this review, we describe the expanding view of selective neuronal vulnerability in HD, based on recent neuropathological and neuroimaging studies. We will also summarize the systematic effort to define the cell types in which mutant Huntingtin expression is critical for pathogenesis of vulnerable neurons in the striatum and cortex. Finally, we will describe selected, emerging molecular mechanisms that are implicated in selective disease processes in HD. Together, the field has begun to appreciate the distinct molecular pathogenic roles of mutant huntingtin in different cell types that may contribute to the selective neuronal vulnerability, with dissection of such mechanisms likely to yield novel molecular targets for HD therapy.

关键词： Huntington＇s disease neurodegeneration selective neuronal vulnerability cortex striatum conditional mouse model cell-autonomous toxicity pathological cell-cell interaction pathogenesis therapeutic targets

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Tim-3 Signaling Determines Intestinal Homeostasis and Diseases by Regulating Macrophage Polarization——Tim-3: A therapeutic Target for Intestinal Diseases

Tim-3 Signaling Determines Intestinal Homeostasis and Diseas...

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第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： Gencheng HAN Yan LI Beifen SHEN Institute of Basic Medical Sciences Academic of Military Medical Sciences

We previously found that T cell immunoglobulin and mucin domain protein 3(Tim-3)signaling contributed to intestinal homeostasis while the underlying mechanisms remain unclear.Here we demonstrate that

关键词： Tim-3 macrophage Intestinal homeostasis therapeutic targets

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