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therapeutic evaluation on Complex Interventions of Integrative Medicine and the Potential Role of Data Mining

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Chinese Journal of Integrative Medicine 2010年第5期16卷 466-471页

作者：邱禹徐浩赵冬琰 Beijing University of Chinese Medicine National Integrative Medicine Center for Cardiovascular Disease China-Japan Friendship Hospital

It is a common view that the integration of Chinese medicine （CM） and modern Western medicine is an efficient way to facilitate the development of CM. Integrative medicine is a kind of complex interventions. Scientific therapeutic evaluation plays a crucial role in making integrative medicine universally acknowledged. However, the modern method of clinical study, which is based on the concept of evidence-based medicine, mostly focuses on the population characteristics and single interventional factor. As a result, it is difficult for this method to totally adapt to the clinical features of CM and integrative medicine as complex interventions. One possible way to solve this issue is to improve and integrate with the existing method and to utilize the evaluation model on complex interventions from abroad. As an interdisciplinary technique, data mining involves database technology, artificial intelligence, machine learning, statistics, neural network and some other latest technologies, and has been widely used in the field of CM. Therefore, the application of data mining in the therapeutic evaluation of integrative medicine has broad prospects.

关键词： integrative medicine Chinese medicine complex intervention therapeutic evaluation data mining

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Acupuncture is ineffective for chronic low back pain?A critical analysis and rethinking

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Frontiers of Medicine 2021年第5期15卷 767-775页

作者： Xuqiang Wei Baoyan Liu College of Acupuncture and Orthopedic Hubei University of Chinese MedicineWuhan 430065China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Acupuncture is a promising treatment for relieving pain and improving lower back function in clinical ***,evidence from randomized clinical trials(RCTs)remains *** RCTs conclude that acupuncture procedures for chronic low back pain(CLBP)had no significant difference in efficacy and belonged to *** carefully reviewed and analyzed the methodology and implementation of sham acupuncture in *** evidence of acupuncture for CLBP is only a microcosm of the evaluation methodological limitation of *** selection of sham acupuncture controls,rigorous RCT research models,and incorrect interpretation of results may contribute to negative *** and disregarding the holistic efficacy of acupuncture with an explanatory RCT model based on evaluation drugs may be ***,sham acupuncture is often proven to be non-inert,unreasonable,and with low *** of the explanatory RCT model and sham acupuncture design should be *** a new evaluation system that is in line with the clinical characteristics of acupuncture and obtaining high-quality evidence are difficult but promising tasks.

关键词： chronic low back pain sham acupuncture acupuncture methodology therapeutic evaluation

Under the narrative medicine theory to establish the evidence-based medical record written by doctors and patients through integrated therapy of traditional Chinese and western on digestive system diseases

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Traditional Medicine Research 2017年第2期2卷 80-87页

作者： Bo Li Gui-Hua Tian Rui Gao Ying-Pan Zhao Qing-Na Li Yang Zhao Hong-Cai Shang Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing Institute of Traditional Chinese MedicineBeijing 100010China TuiNa and Pain Department and Beijing Dongzhimen HospitalBeijing University of Chinese Medicine100700BeijingChina China Academy of Chinese Medical Sciences Institute of Clinical Pharmacology Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese Medicine.

Objective:The aim of this article was to discuss the theory of doctor-patient co-operated evidence-based medical record and set up the preliminary frame of the doctor-patient co-operated evidence-based medical record following the concept of narrative evidence-based ***:The information was searched from Pubmed,Embase,CBMdisc,CNKI.A preliminary agreement was reached by referring to the principles of narrative medicine and advises given by experts of digestive system and evidence-based medicine in both Traditional Chinese Medicine and Western ***:This research is a useful attempt to discuss the establishment of doctor-patient co-operated evidence-based medical record guided by the direction of narrative evidence-based *** and outlook:Doctor-patient co-operated medical record can be a key factor of the curative effect evaluation methodology system of integrated therapy of Tradition Chinese Medicine and Western Medicine on spleen and stomach diseases.

关键词： Evidence-based medicine Narrative medicine therapeutic evaluation Evidence-based medical record by doctor and patient

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杠杆定位手法治疗腰椎间盘突出症临床研究

杠杆定位手法治疗腰椎间盘突出症临床研究