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Albumin-based theranostic Nanosystem for Drug Controlled Release and Magnetic Resonance Imaging Guided therapy

Journal of Bionic Engineering 2022年第1期19卷 188-196页

作者： Qiaoying Wang Jiali Cai Zihan Xu Shihui Huang Ruiping Zhou Zhiyong Wang Leshan Vocational and Technical College Leshan614000China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Materials Science and EngineeringCenter for Functional BiomaterialsSun Yat-sen UniversityGuangzhou510275China Department of stomatology Shenzhen Yantian District People’s HospitalShenzhen518081China

Chemotherapy is still a kind of important strategy for cancer treatment,but lacking effective delivery system limits the therapeutic *** to the excellent biocompatibility,albumin has been employed as drug vehicle;however,it has to face complicated synthesis procedures and still needs an effective technology for the drug delivery *** this study,a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs;furthermore,the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance *** nanosystem with a stable structure exhibited about 80 nanometer size and 7.7[Mn]mM-1S-1 T1 relaxivity;moreover,the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer ***,the nanocomposites effectively entered into the cancer cells and showed superior antitumor ability;and these treated cells exhibited significant T1 *** results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.

关键词： Drug delivery system Magnetic resonance imaging theranostic therapy Self-assembly

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