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Uniphyline-Induced Hypophosphatemia: A Rare Etiology of Severe Respiratory Failure

Health 2023年第7期15卷 810-813页

作者： Hassan Mohammed Ismael Mohammed Farooq Ahmad Mohamed Abdalrahman Ghazy Mohamed Gastroenterology/Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Diabetes and Endocrinology Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Acute Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK University Hospital Coventry NHS Trust Coventry UK

Hypophosphataemia is defined as low level of phosphate in the blood (normal range 0.8 - 1.4 mmol/l), which can be drug-induced such as uniphyline. We present a case of elderly female patient with known chronic obstructive pulmonary disease, admitted with acute respiratory failure and low serum phosphate level, her clinical signs and serum phosphate level did not improve with conventional therapy and intravenous phosphate replacement, until her recently commenced uniphyline was discontinued. This highlights the importance of awareness amongst the clinicians about this rare but potential side effect of uniphyline. We suggest monitoring phosphate levels in patients admitted with acute respiratory failure especially those on extended bronchodilator therapy.

关键词： Hypophosphatemia Acute Respiratory Failure Chronic Obstructive Pulmonary Disease Uniphyline theophyline Bronchodilator Therapy

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Bio-Medical Aspects of Purine Alkaloids

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Advances in Biological Chemistry 2014年第4期4卷 274-280页

作者： Milan Melnik Ondrej Sprusansky Peter Musil Department of Pharmacology and Toxicology Faculty of Pharmacy Comenius University Bratislava Slovak Republic

This review shortly summarized bio-medical activities of purine alkaloids, caffeine (caf), theophyline (top) and theobromine (tob). Caffeine potentiates the cytotoxicity of a variety of DNA domaging agents. Caffeine increased antitumor activity of some cancerostatic drugs. Caffeine inhibits the carcinogenic activity of cigarette smoke, significantly potentiating the therapeutic effect of acetaminophenol, cyclophosphoramide, enhances lipid oxidation, affects the central nervous system and alters cardiovascular system. theophyline has expressive anti-inflammatory and antiasthmatic effect, and enhanced mobilization of lipid reduces the brain regional adenylate cyclase activity, facilitates glucose inhibition. theophyline is muscle relaxant, vasodilator, diuretic and cardiac stimulant. Theobromine increases antitumor activity of adriamycin and doxorubicin, has expressive anti-inflammatory effect and it is classical diureticum. Several examples of caffeine with some organic substrates as well as with copper are also outlined. Increasing activity of the respective drugs in the present of the purine alkaloids can be ascribed to direct interaction as was proved by X-ray data of some caffeine adducts with organic substances as well as Cu(II) complexes.

关键词： Bio-Medical Activity Caffeine Purine Alkaloids theophyline Theobromine

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