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Circle of Willis atherosclerosis, Alzheimer's disease and the dean number

World Journal of Cardiology 2013年第10期5卷 394-396页

作者： Rovshan M Ismailov Complex Mechanisms of Disease Aging and Trauma (CMDAT) Research Foundation

The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become *** such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may not fully explain the specific involvement of the Circle of Willis in these *** Circle of Wills is a complex geometrical structure which has several areas with different curvature as well as various branching angles of vessels composing the *** hemodynamics in this region should take into account the dean number which indicates the influence of curvature on the resistance to blood ***,areas with various curvature and angles may have different hemodynamics and there are certain areas in the Circle of Willis that are more likely to develop atherosclerotic ***,this could suggest the novel pathophysiological pathway resulting from the geometric peculiarities of the Circle of *** of the directions of future research is to examine whether specific areas of the Circle of Willis are more likely to develop atherosclerotic changes compared to other *** areas of the Circle of Willis affected by atherosclerotic changes could indicate the primary role of atherosclerosis promoting Alzheimer's disease although other pathophysiological mechanisms suggesting the opposite direction should be also examined in prospective studies.

关键词： Circle of Willis Alzheimer’ s disease Atherosclerosis Mechanism the dean number

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