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PKC/TRPV1通路在大鼠三叉神经痛中的病理作用

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安徽医科大学学报 2024年第5期 846-851页

作者：吴贝贝沈莲王元银王烈成安徽医科大学口腔医学院安徽医科大学附属口腔医院安徽省口腔疾病研究重点实验室安徽医科大学基础医学院生理学教研室

目的探究蛋白激酶C(PKC)/瞬时感受器电位香草酸亚型1(TRPV1)通路在大鼠三叉神经疼痛（TN）中的病理作用。方法采用眶下神经慢性收缩术（ION-CCI）来创建大鼠TN的模型。将大鼠随机分为假手术组（Sham组）、CCI组、CCI+DMSO组、CCI+GF10... 详细信息

目的探究蛋白激酶C(PKC)/瞬时感受器电位香草酸亚型1(TRPV1)通路在大鼠三叉神经疼痛（TN）中的病理作用。方法采用眶下神经慢性收缩术（ION-CCI）来创建大鼠TN的模型。将大鼠随机分为假手术组（Sham组）、CCI组、CCI+DMSO组、CCI+GF109203X（双吲哚马来酰亚胺，一种PKC抑制剂）组。使用Von Frey毛刷检测大鼠的机械痛阈。采用qRT-PCR及Western blot分别检测三叉神经节（tg）内PKC和TRPV1表达量的变化。HE染色观察tg的病理变化。结果 CCI组大鼠机械痛阈降低（Ptg内的磷酸化的PKC(p-PKC)和TRPV1表达显著增加（Ptg出现明显的炎性细胞浸润增多、神经细胞肿胀等变化。注射GF109203X后降低了大鼠tg内PKC的磷酸化和TRPV1的表达，大鼠机械痛阈升高（Ptg内细胞肿胀和炎症细胞有所减少。结论 PKC/TRPV1通路可能参与了大鼠的三叉神经痛。

关键词： PKC TRPV1 tg 三叉神经痛机械痛阈

tg和Py-GC/MS研究不同烟草的热解特性

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西北民族大学学报（自然科学版） 2024年第1期45卷 14-24页

作者：苏小平申涛张平苏琼王彦斌孙鸣马晓迅西北民族大学化工学院、环境友好复合材料国家民委重点实验室、甘肃省生物质功能复合材料工程研究中心、甘肃省高校环境友好复合材料及生物质利用重点实验室甘肃兰州730030 西北大学化工学院、碳氢资源清洁利用国家国际科技合作基地、陕北能源先进化工利用技术教育部工程研究中心、陕西省洁净煤转化工程技术中心陕西西安710069

利用tg和Py-GC/MS对兰州、猴王和中华三种香烟的烟丝进行了热解特性分析,并用商业烟嘴过滤器和GC/MS对香烟中的烟焦油进行了收集与组成分析.结果表明,三种品牌的香烟烟丝在相同的气氛下热失重曲线的变化基本类似.热失重主要发生在第Ⅱ(... 详细信息

利用tg和Py-GC/MS对兰州、猴王和中华三种香烟的烟丝进行了热解特性分析,并用商业烟嘴过滤器和GC/MS对香烟中的烟焦油进行了收集与组成分析.结果表明,三种品牌的香烟烟丝在相同的气氛下热失重曲线的变化基本类似.热失重主要发生在第Ⅱ(120℃~360℃)和第Ⅲ(360℃~600℃)阶段,与N_(2)气氛相比,O_(2)气氛下烟丝的热解速率和总失重明显增加,尤其对第Ⅲ阶段的热解有明显促进作用.三种香烟的烟丝热解挥发分中组分含量不同,兰州、猴王和中华烟的烟丝热解挥发分中烟碱含量最高,分别达到8.35%、6.53%和6.24%;三种品牌香烟的烟焦油含量大小顺序为中华>兰州>猴王.三种香烟的烟焦油组成差异明显,兰州烟和中华烟的烟焦油中含量最高的是烟碱,而猴王烟的烟焦油中含量最高的是醇类化合物.

关键词：烟丝 tg Py-GC/MS 烟焦油

高频彩超结合血清CD34、tg、VEGF诊断甲状腺癌的临床价值

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医疗装备 2024年第7期37卷 94-96页

作者：杨林靖荆门市中医医院·荆门市石化医院湖北荆门448000

目的分析高频彩超结合血清细胞表面的唾液黏蛋白(CD)34、甲状腺球蛋白(tg)、血管内皮生成因子(VEGF)诊断甲状腺癌的临床价值。方法选取2018年1月至2023年10月医院收治的50例疑似甲状腺癌患者,均采用高频彩超诊断,并检测tg、VEGF、CD34... 详细信息

目的分析高频彩超结合血清细胞表面的唾液黏蛋白(CD)34、甲状腺球蛋白(tg)、血管内皮生成因子(VEGF)诊断甲状腺癌的临床价值。方法选取2018年1月至2023年10月医院收治的50例疑似甲状腺癌患者,均采用高频彩超诊断,并检测tg、VEGF、CD34表达。以手术病理结果为金标准,分为良性组与恶性组,分析对甲状腺癌的诊断价值。结果恶性组收缩期峰值流速(PSV)、阻力指数(RI)高于良性组,血流分级3级占比率高于良性组,纵横比>1、内部微钙化、后方衰减占比率均高于良性组(Ptg、VEGF、CD34表达水平均高于良性组(Ptg、VEGF、CD34预测甲状腺癌的灵敏度(93.30%)、特异度(92.50%)均高于单一指标(Ptg、VEGF表达诊断甲状腺癌的临床价值较高。

关键词：高频彩超 CD34 tg VEGF 甲状腺癌

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高耐热型特种环氧树脂固化物的合成

高耐热型特种环氧树脂固化物的合成

Mechanism of the Initial Stage of Thermal Decomposition of Nitroguanidine

第二十四届中国覆铜板技术研讨会

作者：刘吉瑞朱红军孟令波山东圣泉新材料股份有限公司

环氧树脂固化物凭借其优异的耐热性、耐湿性、耐腐蚀等性能,在各个应用行业大放异彩。伴随半导体元器件集成度提高,封装尺寸薄膜化以及2.5D、3D封装技术的发展,因此开发高耐热、低CTE的特种环氧材料已成为热点。本文综述了近年来日本对... 详细信息

环氧树脂固化物凭借其优异的耐热性、耐湿性、耐腐蚀等性能,在各个应用行业大放异彩。伴随半导体元器件集成度提高,封装尺寸薄膜化以及2.5D、3D封装技术的发展,因此开发高耐热、低CTE的特种环氧材料已成为热点。本文综述了近年来日本对于高耐热型环氧树脂固化物的研究进展,构思了未来环氧树脂事业的发展方向。

关键词：环氧固化物耐热性 tg CTE Td10

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火炸药学报 2023年第1期46卷 31-40页

作者： Boris E.Krisyuk Danila A.Markin Timofey M.Sypko Viktor V.Zakharov Nikita V.Chukanov Boris L.Korsunskiy Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry Russian Academy of Sciences142432prosp.Academician Semenov1ChernogolovkaMoscow RegionRussia Plekhanov Russian University of Economics Department of Chemistry and Physics36 Stremyanny laneMoscow 117997Russia Lomonosov Moscow State University Faculty of Fundamental Physical and Chemical engineeringGSP-11 Leninskie Goryp.51Moscow 119991Russia N.N.Semenov Federal Research Center for Chemical Physics Russian Academy of Science 4 Kosygina StreetBuilding 1Moscow 119991Russia

A theoretical and experimental study of the thermal decomposition of nitroguanidine(NQ) has been carried out. Various thermolysis channels were studied by quantum chemistry methods at the CCSD(or DLPNO-CCSD) level using the aug-cc-pVDZ basis set. It is shown that the lowest activation enthalpies(170-180kJ/mol) are characteristic of the reactions of NO2abstraction from the initial NQ and the reaction channel with the transfer of oxygen from the nitro group to carbon in the limiting stage. Additionally, the thermolysis of NQ was studied experimentally in a nonisothermal mode with heating rates from 1 to 10K/min. In these experiments, the weight loss of the sample, thermal effects, and mass spectra of the products were recorded. An analysis of the experimental data confirmed the results of a theoretical study of the mechanism of thermal decomposition of NQ. The main thermolysis products are N2O, HNCO, NH3, and NO2, which fully corresponds to quantum chemical calculations.

关键词： primary thermolysis steps quantum-chemical calculation mass spectrometry DSC tg

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稀土尾矿中氟碳铈矿分解反应动力学研究

中国稀土学报 2022年第3期40卷 493-499页

作者：侯丽敏乔超越王甜甜许杰陈翰付善聪武文斐内蒙古科技大学能源与环境学院内蒙古自治区高效洁净燃烧重点实验室内蒙古包头014010 内蒙古科技大学白云鄂博矿多金属资源综合利用重点实验室内蒙古包头014010

分解反应动力学可以深入分析氟碳铈矿分解反应过程,基于程序升温热重和质谱数据,采用Li Chung-Hsiung方法和Malek方法确定了氟碳铈矿分解反应过程的最概然机理函数、活化能和指前因子。热重实验结果表明,氟碳铈矿在空气和N_(2)气氛围下4... 详细信息

分解反应动力学可以深入分析氟碳铈矿分解反应过程,基于程序升温热重和质谱数据,采用Li Chung-Hsiung方法和Malek方法确定了氟碳铈矿分解反应过程的最概然机理函数、活化能和指前因子。热重实验结果表明,氟碳铈矿在空气和N_(2)气氛围下400~600℃温度范围内分解,空气氛围更有利于氟碳铈矿分解反应的进行,分解过程可用A模型很好地描述,即氟碳铈矿分解反应的速率控制步骤包含产物成核、核增长和核吸收长大。空气氛围下,氟碳铈矿分解反应过程活化能和指前因子分别为17.657~24.885 kJ·mol^(-1)和6.223~29.653 min^(-1);N_(2)气氛围下,氟碳铈矿分解反应过程活化能和指前因子分别为25.532~30.236 kJ·mol^(-1)和36.882~64.250 min_(-1),基于最概然机理函数、活化能和指前因子,建立了N_(2)气和空气氛围下的稀土尾矿中氟碳铈矿的分解反应动力学模型。

关键词：稀土尾矿分解反应动力学氟碳铈矿 tg

Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice

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Science Bulletin 2017年第24期62卷 1634-1636页

作者： Zhengzhi Cui Shuaishuai Niu Jingjing Liu Lei Xu Yunping Dai Ning Li Youmin Kang Linlin Zhang Lei Zhou Shuyang Yu Beijing Advanced Innovation Center for Food Nutrition and Human Health China Agricultural University Beijing 100193 China State Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China College of Animal Science and Animal Medicine Tianjin Agriculture University Tianjin 300384 China Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture China Agricultural University Beijing 100193 China

Porcine reproductive and respiratory syndrome virus(PRRSV)is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide[1].Porcine alveolar macrophages(PAMs)are the primary target cells of PRRSV[2],and the putative receptors,including CD163,CD169,and CD151,play key roles during infection[3–6].However,the understanding of PRRSV infection and pathogenesis is

关键词： PRRSV CD169 Over-expression of CD163 and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice tg

2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer

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Cancer Biology & Medicine 2018年第4期15卷 468-477页

作者： Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 Department of Head and Neck Tumor Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Head and Neck Zhejiang Cancer HospitalHangzhou 310022China Department of Head and Neck Tumor Fudan University Shanghai Cancer CenterShanghai 200433China Department of General Surgery First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of Nuclear Medicine The Sixth Affiliated Hospital of Shanghai Jiao Tong UniversityShanghai 200025China Department of Endocrinology The First Hospital of China Medical UniversityShenyang 110001China Department of Clinical Laboratory Cancer Hospital Chinese Academy of Medical ScienceBeijing 100021China Department of Head and Neck Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Clinical Laboratory Fudan University Shanghai Cancer CenterShanghai 200433China Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Thyroid and Breast Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Nuclear Medicine Peking Union Medical College HospitalBeijing 100730China Department of Head and Neck Gansu Provincial Cancer HospitalLanzhou 730050China Department of Head and Neck Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of Thyroid Head and NeckHenan Cancer HospitalZhengzhou 450008China Department of Clinical Laboratory Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianj

In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation.

关键词： Chinese expert consensus on the clinical application of serum marker for thyroid cancer MTC tg

Calcium Glucarate Prevents Tumor Formation in Mouse Skin

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Biomedical and Environmental Sciences 2003年第1期16卷 9-16页

作者： JAYASINGH KRISHNAP.GUPTA Environmental Carcinogenesis Division Industrial Toxicology Research CenterPost Box No.80Mahatma Gandhi Marg Lucknow-226001IndiaEnvironmental Carcinogenesis DivisionIndustrial Toxicology Research CenterPost Box No.80Mahatma Gandhi Marg Lucknow-226001India

Objective Calcium Glucarate (Cag), Ca salt of D-glucaric acid is a naturally occurring non-toxic compound present in fruits, vegetables and seeds of some plants, and suppress tumor growth in different models. Due to lack of knowledge about its mode of action its uses are limited in cancer chemotherapy thus the objective of the study was to study the mechanism of action of Cag on mouse skin tumorigenesis. Methods We have estimated effect of Cag on DMBA induced mouse skin tumor development following complete carcinogenesis protocol. We measured, epidermal transglutaminase activity (tg), a marker of cell differentiation after DMBA and/or Cag treatment and [3H] thymidine incorporation into DNA as a marker for cell proliferation. Results Topical application of Cag suppressed the DMBA induced mouse skin tumor development. Topical application of Cag significantly modifies the critical events of proliferation and differentiation tg activity was found to be reduced after DMBA treatment. Reduction of the tg activ

关键词： Cag Skin tumor Chemoprevention tg DNA synthesis Skin Transglutaminase