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A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants

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Science China(Life Sciences) 2023年第8期66卷 1818-1830页

作者： Rui Wang Hongpeng Huang Chulin Yu Chunyun Sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie Beijing Protein and Antibody R&D Engineering Center Sinocelltech Ltd.Beijing 100176China Cell Culture Engineering Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 *** this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant *** the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster ***,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike ***,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 ***01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461).

关键词： tetravalent SARS-CoV-2 vaccine Omicron subvariants broad neutralization

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Synthesis and Crystal Structure of the First Guanidinate Complex of tetravalent Cerium

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Chinese Journal of Structural Chemistry 2013年第3期32卷 408-412页

作者：周媛袁福根李婷婷张曼曼 School of Chemistry and Biochemistry University of Science and Technology of Suzhou

Reaction of Ce（O-t-Bu）2（NO3）2 and sodium guanidinate GuaNa （Gua-=TMS2NC（NC6H11）2-） in THF affords the first guanidinate Ce（IV） complex of Ce2（O-t-Bu）7（Guaˊ）（1, Gua-=（C6H11NH）C（NC6H 11）（NH）-）. It crystallizes in monoclinic, space group P21/n with a=15.2937（14）, b=17.8409（16）, c=19.0454（16）, β=97.713（2）°, V=5149.6（8）3 , Z=4, Mr=1014.38, Dc=1.308 g/cm3 , μ=1.787 mm-1 , F（000）=2104, S=1.015, R=0.0451 and wR=0.0901 （I 〉 2σ（I））. In the reaction the cleavage of TMS-N bonds happened unexpectedly.

关键词： cerium tetravalent guanidinate crystal structure

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Synthesis and Crystal Structure of a tetravalent Cerium Complex with a Bridging Triphenolate Ligand

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Chinese Journal of Structural Chemistry 2014年第2期33卷 258-262页

作者：张曼曼周媛袁福根李理 School of Chemistry and Biochemistry Suzhou University of Science and Technology

Reaction of（NH4）2 Ce（NO3）6 first with NaOtBu in a 1：6 molar ratio in THF, then with an equivalent of 2-bis（salicylidieneamino）methylphenol（H3 salmp） affords the（salmp）2 Ce2-（O）Na4（OtBu）4（THF）4 ·2C6 H6 complex. It crystallizes in monoclinic, space group C2/c with a = 16.5218（14）, b = 23.992（2）, c = 21.9454（18）, β = 97.470（1）°, V = 8625.1（12）3, Z = 4, Mr = 1811.96, Dc = 1.395 g/cm3, μ = 1.126 mm-1, F（000） = 3736, S = 1.061, R = 0.0405 and wR = 0.0932（I 〉 2σ（I））.

关键词： cerium tetravalent crystal structure lanthanide

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Clinical development update: 1st dengue vaccine candidate

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 20-21页

作者： Alain Bouckenooghe Sanofi Pasteur

A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in the Asia-Pacific and Latin American *** report the results of long-term follow-up interim analyses and integrated efficacy *** are assessing the incidence of hospitalization for virologically confirmed dengues a surrogate safety end point during follow-up in years 3–6 of two phase 3 trials,CYD14 and CYD15,and a phase 2b trial,CYD23/*** estimated vaccine efficacy using pooled data from the first 25 months of CYD14 and CYD15.

关键词： Dengue vaccine Candidate tetravalent dengue vaccine

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Epimorphisms between Finite 4-Valued Modal Algebras

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Advances in Pure Mathematics 2014年第5期4卷 222-227页

作者： Aldo V. Figallo Elda Pick Susana Saad Facultad de Ingeniería Universidad Nacional de San Juan San Juan Argentina Instituto de Ciencias Básicas Facultad de Filosofía Universidad Nacional de San Juan San Juan Argentina Instituto de Ciencias Básicas Universidad Nacional de San Juan San Juan Argentina

In this paper, we determine conditions for the existence of an epimorphism between two finite 4-valued modal algebras and state a method to obtain it. Furthermore, we obtain formulas which generalize those indicated by R. Sikorski for finite Boolean algebras [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380037003200340036003100310038000000 , and by M. Abad and A. V. Figallo for finite 3-valued ukasiewicz algebras [2] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380037003200340036003100320031000000 .

关键词： Four Valued Modal Algebras tetravalent Modal Algebras De Morgan Algebra Epimorphisms Automorphisms

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