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In VivoHepato-Protective Properties of the Essential Oils of Boswellia papyrifera(Del.) Hochst (Burseraceae) and Ruta chalepensisL. (Rutaceae)

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Journal of Biosciences and Medicines 2020年第10期8卷 117-131页

作者： Mohamed Abdoul Latif Fatouma Bationo Jean-Hubert Coulibaly Y. Ahmed Yerbanga R. Serge Ouedraogo Gisèle Marie Sophie Medicinal Research Institute/Centre d’Etude et de Recherche de Djibouti (IRM-CERD) Djibouti Djibouti Laboratory of Applied Biochemistry and Chemistry University Joseph KI-ZERBO Ouagadougou Burkina Faso Centre Universitaire de Dori/Université Thomas Sankara Dori Burkina Faso Université Norbert Zongo UFR/ST Koudougou Burkina Faso Institute for Research in Health Science Bobo Dioulasso Burkina Faso National School of Livestock Ouagadougou Burkina Faso

Objective: Boswellia papyrifera (Del.) Hochst and Ruta chalepensis L. are aromatic plants used in the Republic of Djibouti, both as food and medicine. The importance of essential oils of these two species in the treatment of certain pathologies such as inflammations and infections has led to an assessment of their composition in volatile organic compounds and their hepato-protective properties on rats poisoned by carbon tetrachloride (CCl4). Methods: The chemical composition of essential oils studied was determined by GC-MS. The hepato-protective properties of the essential oils of Boswellia papyrifera and Ruta chalepensis were assessed through inhibition of hepato toxicity in rats by CCl4 poisoning. The hepato-protection of essential oils was estimated by measuring biochemical and hematological parameters. Results: Essential oils of Boswellia papyrifera and Ruta chalepensis reduced the blood level of transaminases and triglycerides at the dependent dosage, and restored liver proteins (0.27 g/l) to levels similar to those rats not poisoned by CCl4. Blood levels of uric acid, urea, creatinine and HDL have also been restored to values similar to those of non-poisoned rats. The chemical composition of the essential oils studied shows that Boswellia papyrifera contains incensole acetate (43.76%) and isoincensole (18.42%), and that Ruta chalepensis contains menthyl acetate (29.8%) and piperitone (22.22%). Conclusion: The studies carried out have shown that the essential oils of Boswellia papyrifera and Ruta chalepensis have a hepato-protective potential similar to that of sylimarin (reference hepato-protective substances). The results show that the essential oils of Boswellia papyrifera and Ruta chalepensis could present good prospects in the formulation of phytomedicines for the man

关键词： Essential Oils Hepatoprotection tetrachloride Djibouti

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Readjustment Period for the Methane Chloride Sector

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China Chemical Reporter 2008年第25期19卷 16-16页

作者： By Wen Yongxiang

Methane chlorides include methane monochloride,methane dichloride,methane trichloride and carbon *** China methane monochloride is mainly produced insilicone plants for their

关键词： tetrachloride methane Shandong Jiangsu sector fluo

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Low Temperature Chlorination of Nd2O3by Mechanochemical Method with CCl4

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Materials Sciences and Applications 2013年第7期4卷 419-431页

作者： Takayuki Nagai Shin-Ichi Kitawaki Nobuaki Sato Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai Japan Nuclear Fuel Cycle Engineering Laboratories Japan Atomic Energy Agency Naka Japan Nuclear Fuel Cycle Engineering Laboratories Japan Atomic Energy Agency Naka Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai Japan

For a chlorinating method at low temperature, the possibility of chlorination of Nd2O3 by a mechanochemical reaction with CCl4 was studied using a planetary ball mill. The mechanochemical experiments were conducted by changing the pot materials, milling time, molar ratio of CCl4/Nd2O3, and revolution speed. As the results of obtained products by X-ray diffractometry and Raman spectroscopy, it was confirmed that the chlorination to NdOCl from Nd2O3 with CCl4 was advanced at room temperature in a zirconia or tungsten pot with balls. We found that an extension of the milling time and an increase of the number of ball were effective to the chlorination to NdOCl and that tensile stress remained in the milled powder by using a planetary ball mill.

关键词： Mechanochemical Method Carbon tetrachloride Neodymium Oxide Low Temperature Chlorination Neodymium Oxychloride XRD RAMAN Spectroscopy

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Zhongtong Builds TCS Project

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China Chemical Reporter 2010年第12期21卷 28-28页

Sichuan Meishan Zhongtong Silicon Technology Company Limited broke groundfor its 30 000 t/a trichlorosilane (TCS) and 12 900 t/a quartz powder project inChengmei Industry Cluster,Meishan,Sichuan *** company plans toinvest RMB175 million and has awarded the construction contract to ChinaChengda Engineering Co *** Meishan government began the environmental impact assessment onthis project in January this *** is reported that this project can help

关键词： contract broke quartz tetrachloride

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Comparative study on some selected species of Ocimumgenus on free radical scavenging activity and hepatoprotective activity against CCl4 induced intoxication in rats

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American Journal of Molecular Biology 2013年第4期3卷 183-186页

作者： Myron Green Rajeswara Rao Pragada Sambasivarao Ethadi Bettaiya Rajanna Alcorn State University Mississippi USA AU College of Pharmaceutical Sciences Andhra University Visakhapatnam India

In this study, we compared the in vitro antioxidant property among the selected Ocimum species (O. sanctum, O. americanum, O. basilicum and O. gratissimum) and hepatoprotective activities of their extracts against CCl4 induced intoxication. The results suggested that the four species of Ocimum genus showed variability in Phenolic content and in vitro antioxi-dant activity against DPPH, superoxide and hydroxyl radicals in the following manner: O. sanctum > O. americanum > O. basilicum > O. gratissimum respec-tively. Based on serum AST, ALT, ALP and T. Bil levels, the alcoholic extracts of Ocimum species showed a significant dose dependent (250 mg and 500 mg and 750 mg/kg p.o.) and a protective effect against CCl4 induced hepatotoxicity in albino rats. The results further revealed that the potential hepatoprotective activity of Ocimum sanctum among the Ocimum species.

关键词： Ocimum sanctum Ocimum americanum Ocimum basilicum Ocimum gratissimum Antioxidant Activity Carbon tetrachloride Hepatotoxicity

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Liver cirrhosis and fatty liver

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外科研究与新技术 1995年第2期 99-100页

950330 Effect of tetrandrine on mitochondria of hep-atofibrosis *** Dingguo(李定国),et ***,Shanghai 2nd Med Univ,200092 Chin J Digest1994;14(6):339-341Carbon tetrachloride was used to create the hep-atofibrotic rat *** doses of tetrandrine(Tet) were used to treat these rats in the early andlate hepatofibrotic *** observed that small dos-June 1995 Vol 12 No

关键词： cirrhosis tetrandrine tetrachloride mitochondria Digest doses HBcAg Kupffer maybe labelling

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General Treatment

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China Medical Abstracts(Internal Medicine) 2009年第4期26卷 193-195页

2009402 Combined use of siRNAs specific for TGF-β1,TGF-β1 RI and TGF-β1 RII synergistically inhibits theTGF-β/Smad signaling pathway in rats with acute liver *** Shunling,et *** Infect Dis,Xiangya Hosp,Centr South Univ,Changsha *** Chin J Digestol 2009;17(24):2444-50. Objective To investigate the inhibitory effect of combined use of small interfering RNAs (siRNAs)

关键词： siRNAs Smad Infect interfering tetrachloride collagen signaling cytometry markedly transfection

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Liver and Biliary System Liver cirrhosis and fatty liver

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China Medical Abstracts(Internal Medicine) 2009年第3期26卷 163-166页

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Liver cirrhosis and fatty liver

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China Medical Abstracts(Internal Medicine) 2010年第3期27卷 171-172页

2010348 Role of small ubiquitin-related modifier-1 in the pathogenesis of hepatic fibrosis in rats. XIAO Zhihua(肖志华),et al. Dept Gastroenterol,2nd Affil Hosp,Nanchang Univ,Nanchang *** Chin J Digestol 2010;18(14)... 详细信息

关键词： cirrhosis Nanchang ubiquitin pathogenesis tetrachloride modifier injected saline body

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Phytochemical screening, hepatoprotective and antioxidant effects of leaf extracts of Zapoteca portoricensis

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Advances in Biological Chemistry 2014年第1期4卷 35-39页

作者： Kingsley Nwonu Agbafor Moses Eje Ogbanshi Emmanuel Iroha Akubugwo Biochemistry Department Abia State University Uturu Nigeria Biochemistry Department Ebonyi State University Abakaliki Nigeria

Fresh leaves of Zapoteca portoricensis are used in Eastern Nigeria for management/treatment of various disorders without any scientific basis. Hepatoprotective and antioxidant properties in albino rats, and phytochemical composition of distilled water and ethanol leaf extracts were studied. Fifty-five animals were placed in eleven groups (A-K) of five in each. Different doses (100, 200, 400 and 600 mg/kg body weight) of the extracts, 20 mg/kg body weight of vitamin C (standard antioxidant) and distilled water were orally administered to groups A-H, I and J-K respectively for six consecutive days. On the seventh day, 2.5 ml/kg body weight of carbon tetrachloride (CCl4) was given intraperitoneally to groups A-J, while group K received distilled. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were used to study hepatoprotective effect. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels in the liver were monitored to assess antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, tannins, saponins, flavonoids, anthraquinones, terpenoids and cardiac glycosides in the extracts. Pretreatment of the rats with the extracts produced a significant decrease (p < 0.05) in ALT, AST, GGT and MDA, while the activity of SOD and CAT increased significantly (p < 0.05) relative to the positive control. These results, which were dose-dependent, are indicative of hepatoprotective and antioxidants potentials of the extracts, and may be due to their phytoconstituents.

关键词： Albino Rats Carbon tetrachloride Zapoteca portoricensis Phytochemicals Liver Enzymes Antioxidant Activity

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