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tetrabromobisphenol a exerts thyroid disrupting effects but has little overt impact on postnatal brain development and neurobehaviors in mice

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Journal of Environmental Sciences 2024年第8期142卷 1-10页

作者： Shilin Song Yuanyuan Li Lin Lv Mengqi Dong Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environment Tsinghua UniversityBeijing 100084China

tetrabromobisphenol a(TBBPA)is a widely used brominated flame *** is evidence showing that TBBPA can exert thyroid disrupting effects in mammals,but different results were also reported,along with inconsistent reports regarding its ***,we investigated thyroid disrupting effects and neurotoxicity of TBBPA(5,50,500μg/(kg·day))to male mice following maternal and direct exposure through drinking water,with the antithyroid drug propylthiouracil(PTU)as the positive *** postnatal day(PND)15,we expectedly observed severe thyroid compensatory hyperplasia and cerebellar developmental retardation in PTU-treated *** highest dose of TBBPA also caused thyroid histological alteration but had no effects on cerebellar development in terms of Purkinje cell morphology and the thickness of the internal granular layer and the molecular layer of the *** puberty and adulthood,the thyroid morphological alterations became more pronounced in the TBBPA-treated animals,accompanied by decreased serum thyroid hormone ***,the 50 and 500μg/(kg·day)TBBPA groups showed a significant decrease in the serum level of serotonin,a neurotransmitter associated with anxiety ***,the highest dose group displayed anxiety-like behaviors in the elevated plus-maze test on PND 35,but this neurobehavioral alteration disappeared on PND ***,no changes in neurobehavioral parameters tested were found in TBBPAtreated animals at puberty and ***,all observations show that TBBPA can exert thyroid disrupting effects but has little overt impact on brain development and neurobehaviors in mice,suggesting that thyroid disruption does not necessarily cause overtly adverse neurodevelopmental outcomes.

关键词： tetrabromobisphenol a Thyroid disruption Brain development Neurobehavior Cerebellum

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tetrabromobisphenol a and hexabromocyclododecane in sediments from the Zhujiang(Pearl) River Estuary and South China Sea

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Acta Oceanologica Sinica 2024年第6期43卷 32-37页

作者： Chuyue Long Weiyan Yang Jiaxun Lu Yuanyue Cheng Ning Qiu Sen Du Li Zhang Shejun Chen Yuxin Sun Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety/Key Laboratory of Theoretical Chemistry of Environmental of Ministry of Education School of EnvironmentSouth China Normal UniversityGuangzhou 510006China South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China Research Center of Harmful Algae and Marine Biology Jinan UniversityGuangzhou 510632China University of Chinese Academy of Sciences Beijing 100049China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China

Marine sediments collected from the Zhujiang(Pearl) River Estuary(ZRE) and South China Sea(SCS) were utilized to study the occurrence and spatial distribution of tetrabromobisphenol a(TBBPA) and hexabromocyclododecane(HBCDD).The levels of TBBPA and HBCDD in sediments ranged from not detected(nd) to 6.14 ng/g dry weight(dw) and nd to 0.42 ng/g *** concentrations in marine sediments were substantially higher than *** concentrations of TBBPA and HBCDD in the ZRE sediments were significantly greater than those in the SCS.α-HBCDD(48.7%) and γ-HBCDD(46.2%) were the two main diastereoisomers of HBCDD in sediments from the ZRE,with minor contribution of β-HBCDD(5.1%).HBCDD were only found in one sample from the northern *** enantiomeric fraction of α-HBCDD in sediments from the ZRE was obviously greater than 0.5,indicating an accumulation of(+)-α-*** enantiomers of HBCDD were not measured in sediments from the *** work highlighted the environmental behaviors of TBBPA and HBCDD in marine sediments.

关键词： tetrabromobisphenol a hexabromocyclododecane marine sediments Zhujiang River Estuary South China Sea

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Toxic Effects of tetrabromobisphenol a on Human Hepatocellular Carcinoma Cells(HepG2)Evaluated Using RNA-Seq

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Chemical Research in Chinese Universities 2023年第3期39卷 395-398页

作者： CHANG Haoran DING Qingjiang WANG Halin The State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing10085P.R.China Sino-Danish College University of the Chinese Academy of SciencesBeijing100049P.R.China Hangzhou Institute for Advanced Study University of the Chinese Academy of SciencesHangzhou310024P.R.China University of the Chinese Academy of Sciences Beijing100049P.R.China

tetrabromobisphenol a(TBBPA)is used as a brominated flame retardant and can easily release into *** has been detected in a variety of environmental media and even in food,making it a new pollutant that is potentially harmful to environment and human ***,the toxicity and underlying mechanism of TBBPA remain to be *** is actively metabolized in the liver,so it is vital to study the hepatocellular toxicity of *** this study,we treated hepatocellular carcinoma cells(HepG2)with TBBPA and searched the differentially expressed genes(DEGs)triggered by TBBPA ***-seq analysis showed that the expression of genes,such as CLIC1 and GATSL1,were significantly down-regulated and PTENP1 was significantly up-regulated after TBBPA exposure,and these genes were involved in cell proliferation and *** down-regulated genes were enriched to peroxisome proliferator-activated receptor(PPAR)signaling pathway and up-regulated genes were enriched to Janus Kinase-signal transduces and activators of transcription(JAK-STAT)signaling pathway,which play a role in regulating cell ***,our transcriptome analysis obtained for TBBPA-treated HepG2 cells implies that TBBPA affects the cell proliferation and growth.

关键词： tetrabromobisphenol a Hepatocellular carcinoma Cytotoxicity RNA-seq

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Biodegradation of tetrabromobisphenol a in the sewage sludge process

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Journal of Environmental Sciences 2017年第11期29卷 39-48页

作者： Xingxing Peng Zhangna Wang Dongyang Wei Qiyuan Huang Xiaoshan Jia School of Environmental Science and Engineering Sun Yat-sen University Guangzhou 510275 China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510275 China South China Institute of Environmental Sciences Cuangzhou 510655 China

Anaerobic sewage sludge capable of rapidly degrading tetrabromobisphenol a（TBBPA） was successfully acclimated in an anaerobic reactor over 280 days. During the period from 0 to 280 days, the TBBPA degradation rate（DR）, utilization of glucose, and VSS were monitored continuously. After 280 days of acclimation, the TBBPA DR of active sludge reached 96.0% after 20 days of treatment in batch experiments. Based on scanning electron microscopy（SEM） observations and denaturing gradient gel electrophoresis（DGGE） determinations,the diversity of the microorganisms after 0 and 280 days in the acclimated anaerobic sewage sludge was compared. Furthermore, eleven metabolites, including 2-bromophenol,3-bromophenol, 2,4-dibromophenol, 2,6-dibromophenol, tribromophenol and bisphenol A,were identified by gas chromatography–mass spectrometry（GC–MS）. Moreover, the six primary intermediary metabolites were also well-degraded by the acclimated anaerobic sewage sludge to varying degrees. Among the six target metabolites, tribromophenol was the most preferred substrate for biodegradation via debromination. These metabolites degraded more rapidly than monobromide and bisphenol A. The biodegradation data of the intermediary metabolites exhibited a good fit to a pseudo-first-order ***, based on the metabolites, metabolic pathways were proposed. In conclusion, the acclimated microbial consortia degraded TBBPA and its metabolites well under anaerobic conditions.

关键词： tetrabromobisphenol a Biodegradation Metabolites Anaerobic sewage sludge Pathways

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Re-evaluation of thyroid hormone signaling antagonism of tetrabromobisphenol a for validating the T3-induced Xenopus metamorphosis assay

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Journal of Environmental Sciences 2017年第2期29卷 325-332页

作者： Yao Wang Yuanyuan Li Zhanfen Qin Wuji Wei College of Environment Nanjing University of TechnologyNanjing 211816China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing I0008SChina University of Chinese Academy of Sciences Beijing 100049China

We developed the T3-induced Xenopus metamorphosis assay, which is supposed to be able to sensitively detect thyroid hormone（TH） signaling disruption of chemicals. The present study aimed to validate the T3-induced Xenopus metamorphosis assay by re-evaluating the TH signaling antagonism of tetrabromobisphenol a（TBBPA）, a known TH signaling disruptor. According to the assay we developed, Xenopus tadpoles at stage 52 were exposed to 10–500 nmol/L TBBPA in the presence of 1 nmol/L T3. After 96 hr of exposure, TBBPA in the range of 10–500 nmol/L was found to significantly inhibit T3-induced morphological changes of Xenopus tadpoles in a concentration-dependent manner in term of body weight and four morphological endpoints including head area（HA）, mouth width（MW）, unilateral brain width/brain length（ULBW/BL）, and hind-limb length/snout-vent length（HLL/SVL）.The results show that these endpoints we developed are sensitive for characterizing the antagonistic effects of TBBPA on T3-induced metamorphosis. Following a 24-hr exposure,we found that TBBPA antagonized expression of T3-induced TH-response genes in the tail,which is consistent with previous findings in the intestine. We propose that the tail can be used as an alternative tissue to the intestine for examining molecular endpoints for evaluating TH signaling disruption. In conclusion, our results demonstrate that the T3-induced Xenopus metamorphosis assay we developed is an ideal in vivo assay for detecting TH signaling disruption.

关键词： Thyroid hormone signaling tetrabromobisphenol a Xenopus metamorphosis T3 induction tail

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