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The effect of scrotal versus inguinal orchiopexy on the testicular function of children with clinically palpable,inguinal undescended testis:a randomized controlled trial

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Asian Journal of Andrology 2023年第6期25卷 745-749页

作者： Wen-Hua Huang Long-Yao Xu Shu-Shen Chen Zhi-Qiang Chen Xu Cui Chao-Ming Zhou Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350005China Department of Urinary Surgery Fujian Children’s HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001China

To compare the impact of the scrotal vs inguinal orchidopexy approach on the testicular function of infants with cryptorchidism,a randomized controlled trial was conducted involving boys who were 6–12 months old at surgery and were diagnosed with clinically palpable,inguinal undescended *** June 2021 and December 2021,these boys at Fujian Maternity and Child Health Hospital(Fuzhou,China)and Fujian Children’s Hospital(Fuzhou,China)were *** randomization with a 1:1 allocation ratio was *** primary outcome was testicular function assessed by testicular volume,serum testosterone,anti-Müllerian hormone(AMH),and inhibin B(InhB)*** outcomes included operative time,amount of intraoperative bleeding,and postoperative *** 577 screened patients,100(17.3%)were considered eligible and enrolled in the *** the 100 children who completed the 1-year follow-up,50 underwent scrotal orchidopexy and 50 underwent inguinal *** testicular volume,serum testosterone,AMH,and InhB levels in both groups increased markedly after surgery(all P0.05).No differences between the scrotal and inguinal groups were noted regarding the operative time(P=0.987)and amount of intraoperative bleeding(P=0.746).The overall complication rate(2.0%)of the scrotal group was slightly lower than that of the inguinal group(8.0%),although this difference was not statistically significant(P>0.05).Both scrotal and inguinal orchiopexy exerted protective effects on testicular function in children with cryptorchidism,with similar operative status and postoperative *** orchiopexy is an effective alternative to inguinal orchiopexy in children with cryptorchidism.

关键词： cryptorchidism orchiopexy scrotum testicular function

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Relationship between testicular volume and testicular function： comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility

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Asian Journal of Andrology 2008年第2期10卷 319-324页

作者： Hideo Sakamoto Yoshio Ogawa Hideki Yoshida Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan

Aim： To evaluate the relationship between testicular function and testicular volume measured by using Prader orchidometry and ultrasonography （US） to determine the critical testicular volume indicating normal testicular function by each method. Methods： Total testicular volume （right plus left testicular volume） was measured in 794 testes in 397 men with infertility （mean age, 35.6 years） using a Prader orchidometer and also by ultrasonography. Ultrasonographic testicular volumes were calculated as length x width x height x 0.71. To evaluate volume-function relationships, patients were divided into 10 groups representing 5-mL increments of total testicular volume by each method from below 10 mL to 50 mL or more. Results： Mean total testicular volume based on Prader orchidometry and US were 36.8 mL and 26.3 mL, respectively. Semen volume, sperm density, total sperm count, total motile sperm count, and serum FSH, LH, and testosterone all correlated significantly with total testicular volume measured by either method. Mean sperm density was in the oligozoospermic range in patients with total testicular volume below 35 mL by orchidometry or below 20 mL by ultrasonography. Mean total sperm count was subnormal in patients with total testicular volume below 30 mL by orchidometry or under 20 mL by ultrasonography. Conclusion： testicular volume measured by either ultrasonography or Prader orchidometry correlated significantly with testicular function. However, critical total testicular volume indicating normal or nearly normal testicular function was 30 mL to 35 mL using Prader orchidometer and 20 mL using ultrasonography. Prader orchidometry morphometrically and functionally overestimated the testicular volume in comparison to US. （Asian JAndro12008 Mar; 10： 319-324）

关键词： orchidometer ultrasonography testicular volume testicular function

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Pharmacological action of quercetin against testicular dysfunction:A mini review

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Journal of Integrative Medicine 2022年第5期20卷 396-401页

作者： Damilare E.Rotimi Tomilola D.Olaolu Oluyomi S.Adeyemi SDG 03 Group–Good Health&Well-being Landmark UniversityOmu-Aran 251101Kwara StateNigeria Department of Biochemistry Medicinal BiochemistryNanomedicine&Toxicology LaboratoryLandmark UniversityOmu-Aran 251101Kwara StateNigeria

The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative ***,the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive *** possesses several pharmacological activities that may help to combat cellular reproduction-related assaults,such as altered sperm function and reproductive hormone dysfunction,and dysregulated testicular apoptosis,oxidative stress,and *** have shown that quercetin ameliorates testicular toxicity,largely by inhibiting the generation of reactive oxygen species,with the aid of the two antioxidant pharmacophores present in its ring *** radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis,prevent inflammation,and increase sperm quality in relation to the hormonal *** this review,the therapeutic potential of quercetin in mediating male reproductive health is discussed.

关键词： Antioxidants Apoptosis Oxidative stress Quercetin Sperm testicular function

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Therapeutic levels of short-term tramadol administration negatively affect testis function in rats

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Asian pacific Journal of Reproduction 2021年第1期10卷 29-35页

作者： Jonah Sydney Aprioku Benjamin Toochukwu Okpe Doupere Ben Department of Experimental Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Port HarcourtPMB 5323East-West RoadRivers StateNigeria Department of Pharmacology and Toxicology Faculty of PharmacyNiger Delta UniversityWilberforce IslandBayelsa StateNigeria

Objective:To investigate the effects of 30-day treatment with therapeutic dose equivalent levels of tramadol on serum testosterone level,sperm parameters,and testicular histology in ***:Thirty-five Wistar rats were equally divided into seven *** 1(the control group)received distilled water(0.5 mL)daily for 30 *** 2-4 were gavaged with therapeutic dose equivalent levels of tramadol(1.25,2.50 and 5.00 mg/kg/day body weight,respectively)in two equal divided doses for 30 consecutive days,and sacrificed on day *** 5-7 received similar tramadol treatments as above but they were allowed for another 30 days to recover after receiving the last dose and sacrificed on day 61 for reversibility *** testosterone level and epididymal sperm were analyzed,and histopathological examination of the testis was carried ***:Tramadol treatment significantly decreased serum testosterone levels compared with the control ***,tramadol treatment inhibited sperm motility and significantly and dose-dependently decreased sperm count and viability compared with the control *** addition,tramadol significantly increased morphological abnormalities in sperm(Ptesticular histology,but they are reversible at lower doses.

关键词： Tramadol Testosterone Sperm parameters Opioid analgesic testicular function

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【特刊综述】迟发型性腺功能减退症：发病机制、诊断、和治疗的现有概念以及争议

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Asian Journal of Andrology 2014年第2期16卷 192-202,I0007页

作者： Ilpo Huhtaniemi Institute of Reproductive and Developmental Biology Imperial College London Hammersmth Campus London UK Department of Physiology University of Turku Kiinamyllynkatu Turku Finland.

Although suppressed serum testosterone （T） is common in ageing men, only a small proportion of them develop the genuine syndrome of low T associated with diffuse sexual （e.g., erectile dysfunction）, physical （e.g. loss of vigor and frailty） and psychological （e.g., depression） symptoms. This syndrome carries many names, including male menopause or climacterium, andropause and partial androgen deficiency of the ageing male （PADAM）. Late-onset hypogonadism （LOH） describes it best and is therefore generally preferred. The decrease of T in LOH is often marginal, and hypogonadism can be either due to primary testicular failure （low T, high luteinizing hormone （LH）） or secondary to a hypothalamic-pituitary failure （low T, low or inappropriately normal LH）. The latter form is more common and it is usually associated with overweight/obesity or chronic diseases （e.g., type 2 diabetes mellitus, the metabolic syndrome, cardiovascular and chronic obstructive pulmonary disease, and frailty）. A problem with the diagnosis of LOH is that often the symptoms （in 20%-40% of unselected men） and low circulating T （in 20% of men 〉70 years of age） do not coincide in the same individual. The European Male Ageing Study （EMAS） has recently defined the strict diagnostic criteria for LOH to include the simultaneous presence of reproducibly low serum T （total T 〈11 nmol 1-1 and free T 〈220 pmol 1-1） and three sexual symptoms （erectile dysfunction, and reduced frequency of sexual thoughts and morning erections）. By these criteria, only 2% of 40- to 80-year-old men have LOH. In particular obesity, but also impaired general health, are more common causes of low T than chronological age per se. Evidence-based information whether, and how, LOH should be treated is sparse. The most logical approach is lifestyle modification, weight reduction and good treatment of comorbid diseases. T replacement is widely used for the treatment, but evidence-based information about its real benefits and short- and lo

关键词： hypogonadism male ageing obesity testicular function testosterone

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