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Aceclofenac-induced hepatotoxicity:An ameliorative effect of terminalia bellirica fruit and ellagic acid

World Journal of Hepatology 2020年第11期12卷 949-964页

作者： Ashutosh Gupta Abhay K Pandey Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia

BACKGROUND Aceclofenac(ACF),a widely used nonsteroidal anti-inflammatory drug,has been associated with a number of severe cases of clinical *** bellirica,an evergreen tree,is known to have several ethnomedicinal uses including antioxidant and hepatoprotective *** *** fruit extracts and its phytoconstituent ellagic acid(EA)are expected to provide protection against oxidative stress and liver damage produced by long-term use of *** To evaluate the antioxidant and hepatoprotective activities of *** fruit extracts and EA against ACF-induced toxicity in albino Wistar *** The in vitro antioxidant activities of *** fruit ethyl acetate and aqueous extracts were measured by metal ion chelation and nitric oxide radical scavenging *** in vivo antioxidant and hepatoprotective effects of *** extracts(200 mg/kg)and EA(40 mg/kg)in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 ***(40 mg/kg)was used as a standard *** stress markers in the blood(ferric reducing ability of plasma and lipid peroxidation inhibition)and liver tissues(superoxide dismutase,catalase and malondialdehyde)were analyzed using standard *** function markers such as alkaline phosphatase,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,lactate dehydrogenase,γ-glutamyl transferase,creatinine,total protein,and uric acid were evaluated in rat *** The *** fruit ethyl acetate extract exhibited superior metal ion chelating and nitric oxide radical scavenging abilities during in vitro antioxidant assays as compared to aqueous *** administration of ACF in rats(15 mg/kg)for 21 d produced oxidative stress and adversely affected liver function suggesting liver *** with extracts(ethyl acetate and aqueous),EA and silymarin accounted for a significant reduction in the adverse effects of ACF on oxidative

关键词： terminalia bellirica Ellagic acid Aceclofenac Hepatotoxicity Antioxidant Histopathology

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