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Quality assurance of postharvest grapes against Botrytis cinerea by terbinafine

Natural Products and Bioprospecting 2023年第1期13卷 502-513页

作者： Yun Zhao Qiong Jin Zi-Jiao Wang Xing-Yu Tao Xiao-Dong Luo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education and Yunnan ProvinceYunnan Characteristic Plant Extraction LaboratorySchool of Chemical Science and TechnologyYunnan UniversityKunming 650500People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Worldwide,fruit is an indispensable treasure house of nutrition for human beings,occupying a vital position of human *** fruit storage requires efficient antifungal agents to control Botrytis cinerea,which is a vital postharvest disease affecting fruit and leading to enormous ***,with the enormous abuse of existing antifungal drugs,the problem of drug-resistant fungi is imminent,making the controlling diseases caused by pathogenic fungi even more *** repurposing is an efficient alternative method,we evaluated a well-known antifungal chemical,terbinafine,against the agricultural pathogen,*** in vitro,as a result,terbinafine showed strong anti-fungal ***,the in vivo antifungal activity of terbinafine was evaluated,the results showed that terbinafine could reduce the decay area on *** could disrupt the cell membrane integrity,increase cell membrane permeability,and eventual cell death of *** addition,terbinafine reduced decay incidence,and weight loss and maintained the soluble solids,titratable acidity,ascorbic acid,total phenolic,and malondialdehyde content during the storage period of ***,terbinafine could be an antifungal preservative for postharvest table grapes fresh-keeping.

关键词： terbinafine Botrytis cinerea Antifungal activity Cell membrane Grape preservation

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Genome-wide expression profiling of the response to terbinafine in Candida albicans using a cDNA microarray analysis

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Chinese Medical Journal 2007年第9期120卷 807-813页

作者： ZENG Yue-bin QIAN Yuan-shu MA Lian GU Hong-ni The Second Affiliated Hospital of Shantou University Medical College Shantou 515041 China Department of Pharmacology Shantou University Medical College Shantou 515041 China

Background Candida albicans is the most frequently seen opportunistic human fungal pathogen. terbinafine is an allylamine antifungal agent that has been proven to have high clinical efficacy in the therapy of fungal infections, the mechanism of action of terbinafine involves the specific inhibition of fungal squalene epoxidase, resulting in ergosterol deficiency and accumulation of intracellular squalene. We used cDNA microarray analysis technology to monitor global expression profile changes of Candida albicans genes in response to terbinafine treatment, and we anticipated a panoramic view of the responses of Candida albicans cells to the representatives of allylamine antifungal agents at the molecular level in an effort to identify drug class-specific and mechanism-independent changes in gene expression.Methods Candida albicans strain ATCC 90028 was exposed to either medium alone or terbinafine at a concentration equivalent to the 1/2 minimal inhibitory concentrations （MICs, 4 mg/L） for 90 minutes. RNA was isolated and gene expression profiles were compared to identify the changes in the gene expression profile using a cDNA microarray analysis. Differential expression of 10 select genes detected by cDNA microarray analysis was confirmed by semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR）. Results A total of 222 genes were found to be responsive to terbinafine, including 121 up-regulated genes and 101 down-regulated genes. These included genes encoding membrane transport proteins belonging to the members of the ATP-binding cassette （ABC） or major facilitator supeffamily （MFS; CDR1, AGP2, GAP6, PHO84, HOL3, FCY23, VCX1）, genes involved in stress response and detoxification （CDR1, AGP2, HOL3）, and gene involved in the ergosterol biosynthesis pathway （ERG12）. The results of semi-quantitative RT-PCR were consistent with that of the cDNA microarray analysis. Conclusions The up-regulation of the gene encoding the multidrug resistance efflu

关键词： Candida albicans terbinafine microarrays gene regulation efflux pumps

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Effect of topical application of terbinafine on fungal keratitis

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Chinese Medical Journal 2009年第16期122卷 1884-1888页

作者： LIANG Qing-feng JIN Xiu-ying WANG Xiang-lan SUN Xu-guang Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100005 China

Background Fungal keratitis is a rare but serious corneal disease that may result in loss of vision. The poor prognosis might be due to limited treatment option. This study aimed to evaluate the clinical efficacy of 0.25% terbinafine eye drops comparing with 5% natamycin suspension on fungal keratitis. Methods A retrospective clinical trial was performed on 90 patients presenting with direct smear and/or culture positive fungal keratitis at Beijing Tongren Hospital, Beijing, China from January 2006 to May 2008. Corneal ulcers were categorized as mild or severe. Forty-five patients were treated with topical terbinafine and the next 45 cases received topical natamycin hourly. Results Filamentous fungi were found in corneal scrapings among all 90 cases. Fungal cultures were positive in 64 patients （71%）. Species of Fusarium and Aspergillus were the principal isolates. Forty （89%） patients showed favorable response to terbinafine, while forty-two （93%） patients exhibited favorable response to natamycin （P 〉0.05）. The mean course of treatment was significantly showed in the terbinafine treatment group than natamycin group （（26.5±11.2） days versus （19.3±6.4） days; P 〈0.05）. In terbinafine group, twenty patients with ulcers smaller than 4 mm had favorable outcome, while 20 of 25 patients with ulcers more than 4 mm in diameter had favorable response （P 〈0.05）. Twenty-seven patients with depth of infiltration less than half of stroma thickness had favorable response to terbinafine, while 13 of 18 patients with depth of infiltration more than half of stroma responded to terbinafine. This difference was statistically significant （P 〈0.05）. Conclusions Our findings suggest that topical terbinafine is an effective antifungal drug for the management of filamentous mycotic keratitis, particularly in cases with smaller and shallower ulcers. Its mean duration of treatment was longer than natamycin.

关键词： terbinafine natamycin keratitis fungal therapy

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Evaluation of the Permeation and Penetration of Two Formulations of terbinafine Chlorhydrate Incorporated in Liposomes (Cream 1%) vs. a Conventional Formulation (Cream 1%), in an <i>in Vitro-ex Vivo</i>Model

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Journal of Biosciences and Medicines 2019年第8期7卷 119-133页

作者： Sanabria Kinski Annunziato Maria Antonieta Chacon Nicolas Inatti Alfredo Department of Nanotechnology of Laboratories Leti S.A.V. GuarenasVenezuela Department of Research and Development Laboratories Biocontrolled C.A.GuarenasVenezuela

In this trial, a topical formulation of a 1% liposome TH cream was compared to a conventional TH formulation. Permeation was evaluated through a synthetic membrane. The study provided information on the rate of diffusion and percentage of drug release and also compared the penetration dynamics in the layers of the stratum corneum of both formulations. Liposome TH cream was able to deliver the active ingredient to a larger number of SC layers, with a higher amount of drug, which is very promising for the treatment of superficial mycoses.

关键词： Antifungal Franz Diffusion Cell Tape Striping Method Liposome terbinafine HCl Drug Carrier Systems Stratum Corneum

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新型抗真菌药（terbinafine）

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中国医院药学杂志 1994年第5期 232-233页

作者：张玮张桂玉苑辉卿王光芳山东医学科学院山东省潍坊市人民医院临床药物研究室

新型抗真菌药（Ｔｅｒｂｉｎａｆｉｎｅ）张玮，张桂玉，苑辉卿，王光芳（山东省潍坊市人民医院临床药物研究室２６１０４１）抗真菌药Ｔｅｒｂｉｎａｆｉｎｅ（商品名Ｌａｍｉｓｉｌ，简称ＴＢＦ）为烯丙胺类第一个口服有效的药物，由... 详细信息

新型抗真菌药（Ｔｅｒｂｉｎａｆｉｎｅ）张玮，张桂玉，苑辉卿，王光芳（山东省潍坊市人民医院临床药物研究室２６１０４１）抗真菌药Ｔｅｒｂｉｎａｆｉｎｅ（商品名Ｌａｍｉｓｉｌ，简称ＴＢＦ）为烯丙胺类第一个口服有效的药物，由英国Ｓａｎｄｏｚ公司研制成功并于１...

关键词：抗真菌药张玮真菌本品潍坊市人民医院山东省张桂玉药物抗霉菌药抗感染药国外药讯 terbinafine

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甲癣与terbinafine

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International Journal of Dermatology And Venereology 1990年第6期 374-375页

作者：李春元

由皮癣菌引起的甲癣是一种常见病,念珠菌属及短帚毒亦可侵犯甲板。Goodfield 等报道用一种新的丙烯胺药terbinafine 治疗甲癣,其真菌治愈的时间约为临床时间的1/2(治疗趾甲癣约为24～44周),故较早即可清除真菌;而用其他治疗时真菌及临... 详细信息

由皮癣菌引起的甲癣是一种常见病,念珠菌属及短帚毒亦可侵犯甲板。Goodfield 等报道用一种新的丙烯胺药terbinafine 治疗甲癣,其真菌治愈的时间约为临床时间的1/2(治疗趾甲癣约为24～44周),故较早即可清除真菌;而用其他治疗时真菌及临床治愈可同时发生。这些结果表明terbinafine 对甲板的穿透性比目前公认的快得多。且对20例作1年随访,各例真菌检查仍阴性,这是其他治疗所不能达到的。在体外低浓度的ter-binafine 可杀灭真菌,这就可以解释为何其可杀灭真菌而不是抑制其生长。即使治疗时间超过6个月亦无副作用。包括terbinafine 在内的丙烯胺抗真菌药物可通过阻止角鲨烯转变为角鲨烯环氧化物而抑制真菌细胞膜形成,terbinafine 杀灭真菌的机理尚不清楚,但早期的报道表明,该药亦可治愈其

关键词：甲癣灰指甲 terbinafine 丙烯胺伯胺

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新型高效抗真菌药——terbinafine

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国外医学（皮肤性病学分册） 1990年第3期16卷 140-142页

作者：周华吴绍熙中国医学科学院皮肤病研究所

terbinafine(商品名lamisil,下简称TBF)是近年来合成的新型广谱丙烯胺类抗真菌药。化学结构式如图所示,该药无论是口服和外用均具有高效杀真菌和抑制真菌的作用,是一个很有前途的药物。1988年在西班牙巴塞罗那召开的国际人和动物真菌学... 详细信息

terbinafine(商品名lamisil,下简称TBF)是近年来合成的新型广谱丙烯胺类抗真菌药。化学结构式如图所示,该药无论是口服和外用均具有高效杀真菌和抑制真菌的作用,是一个很有前途的药物。1988年在西班牙巴塞罗那召开的国际人和动物真菌学会第十届大会举行了TBF首次专题讨论会。现将主要内容综合如下。

关键词： terbinafine 抗真菌药

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口服治疗甲癣期间指甲标本中terbinafine的测定

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International Journal of Dermatology And Venereology 1992年第1期 59-60页

作者：王惠芬

由于甲癣的感染位置深在,局部外用药不能有效地渗透入甲板,故有必要口服抗菌药物来治疗。terbinafine是一种新的丙烯胺抗真菌剂,近来经临床使用表明它对甲癣是有效的。它抑制角鲨烯环氧化酶(一种在真菌麦角甾醇生物合成中的关键酶)而发... 详细信息

由于甲癣的感染位置深在,局部外用药不能有效地渗透入甲板,故有必要口服抗菌药物来治疗。terbinafine是一种新的丙烯胺抗真菌剂,近来经临床使用表明它对甲癣是有效的。它抑制角鲨烯环氧化酶(一种在真菌麦角甾醇生物合成中的关键酶)而发挥其抗真菌作用。为了确定药物最佳剂量及治疗时间,terbinafine与指甲结合的动力学测定是很重要的。然而用一般化学方法(1M NaOH),甚或加用超声波或温热处理,都难以使甲标本良好溶解,以保证最佳的药物萃取。本文对5名自愿者的40余份从甲远端修剪下的标本10～20mg,加入标准

关键词：甲癣灰指甲 terbinafine 标本指甲皮肤

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