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Effect of terazosin on Blood Pressure and Serum Lipids

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1999年第4期19卷 291-294页

作者：龚培力唐家荣程龙献陆再英张金枝曾繁典 Department of Clinical Pharmacology School of Basic Medical Sciences Tongji Medical University Wuhan 430030

In an open multicenter prospective study, the effects of short-term (4weeks, n= 101) and long-term (6 months, n = 38) terazosin treatment on blood pressure, serum lipids and safety in the patients with mild to moderate essential hypertension were observed. Mean systolic and diastolic blood pressure in sitting position were significantly reduced by 16. 4 % and 14. 0 % respectively (Pterazosin therapy, with the total efficacy rate being 87.1 %.During a 6 month therapy, antihypertensive effect of terazosin could be main-tained- Total cholesterol (TC) and low density lipoprotein (LDL ) cholesterol in serum were significantly decreased P terazosin treatment; the levels of TC, LDL and triglyceride were significantly improved in hypertensive patients af-ter 3-6 month terazosin treatment. The improvement of lipid metabolism was re-lated to the dosage of terazosin but not to antihypertensive effects of *** results suggested that terazosin is effective in decreasing blood pressure and improving lipid metabolism. It may serve as a good antihypertensive agent for hy-pertensive patients with hypercholesterolemia.

关键词： terazosin essential hypertension lipid metabolism

Plasma Kinetic Resection of Prostate Combined terazosin for Treatment of BPH Patient with Coexisting Hypertension

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Open Journal of Urology 2014年第5期4卷 57-62页

作者： Ming Zheng Mingqiang Zeng Chonghe Jiang Jinyang Chen Shuren Li Jiaxin Wang Department of Urology Qingyuan City People’s Hospital of Jinan University Qingyuan China Department of Urology Xiangtan Hospital of Nanhua University Xiangtan China

Objective: To evaluate the efficacy and safety of terazosin and plasma kinetic resection of the prostate (PKRP) in the treatment of benign prostatic hyperplasia (BPH) patients with coexisting hypertension. Methods: A total of 205 men who suffered from BPH with concomitant hypertension were enrolled in this study. They all received PKRP surgery and terazosin medication from one week before to 3 months after the operation. The procedures of efficacy and safety were evaluated by analysis of the changes in blood pressures, IPSS, Qmax and the drug related adverse events 4 weeks and 3 months after the operation. Results: The systolic blood pressure decreased from 161 ± 12.33 mmHg at baseline to 148 ± 7.27 mmHg four weeks (P?P?P?P?P?P?

关键词： Benign Prostatic Hyperplasia Hypertension terazosin Plasma Kinetic Vaporization of the Prostate

terazosin—一种新型α1肾上腺素能受体阻滞剂

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中国药理学通报 1993年第1期 63-63页

作者：张安平

受体结合试验表明.terazosin(Ter)为一高度选择性作用于α肾上腺素能受体的药物.主要用于治疗轻中度原发性高血压。药理试验说明,Ter特性与哌唑嗪相似.能选择性作用于突触后膜上的α受体.使外周血管扩张.血管阻力降低,而不明显引起反射... 详细信息

受体结合试验表明.terazosin(Ter)为一高度选择性作用于α肾上腺素能受体的药物.主要用于治疗轻中度原发性高血压。药理试验说明,Ter特性与哌唑嗪相似.能选择性作用于突触后膜上的α受体.使外周血管扩张.血管阻力降低,而不明显引起反射性的心率加快。对α受体作用极弱。临床试验发现。Ter还能使慢性充血性心衰患者的心指数增加13％.血管阻力降低24～29％,使肥大的心脏得到回复。该药口服吸收迅速完全.0.5～1h血浓度达高峰.生物利用度不受食物的影响.与哌唑嗪相比.它的半衰期为前者的3倍.约为12h.一次给药作用可维持24h.因此,只需每日用药一次。此外它的水溶性极高,有利于静脉给药.

关键词：哌唑嗪受体脉宁平抗高血压药血管阻力 terazosin

特拉唑嗪(terazosin)(一种研制中的抗高血压药)

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药学实践杂志 1988年第4期 34-35页

作者：贺全山张紫洞

特拉唑嗪是喹唑啉类的一种抗高血压药。化学结构类似于哌唑嗪,它溶于水并以两种对映体形式存在。药理学特拉唑嗪因选择性阻断α-肾上腺素受体而呈现抗高血压作用。它是通过阻断位于血管平滑肌中的这些受体,松弛

关键词：抗高血压药特拉给药病人降压药 terazosin 本品

特拉唑嗪(terazosin)对充血性心力衰竭的血流动力学和临床效应

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国外医药.合成药.生化药.制剂分册 1987年第5期 312-313页

作者：胡琛

α1受体阻滞剂（?）拉唑嗪（terazosin）对体循环高血压和充血性心力衰竭有潜在治疗价值。血浆半衰期10～12小时,每日口服1～2次即可。作者研究了6例充血性心力衰竭患者口服本品后休息和运动时的血流动力学效应。 6例病人,心功能Ⅲ级。... 详细信息

α1受体阻滞剂（?）拉唑嗪（terazosin）对体循环高血压和充血性心力衰竭有潜在治疗价值。血浆半衰期10～12小时,每日口服1～2次即可。作者研究了6例充血性心力衰竭患者口服本品后休息和运动时的血流动力学效应。 6例病人,心功能Ⅲ级。心衰病史平均10（5～24）个月。以洋地黄和利尿剂维持治疗。

关键词：血流动力 terazosin 充血性心力衰竭

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terazosin抗高血压的量效关系

世界临床药物 1992年第3期 183-183页

作者：刘涛

特拉唑嗪（terazosin）是一种选择性α;-肾上腺素能受体阻断剂,临床用来治疗高血压。为确定该药的量效关系,作者对256例轻、中度原发性高血压患者进行了多中心比较研究。剂量为每日1～80 mg,患者随机分为治疗组和安慰剂对照组,每疗程为... 详细信息

特拉唑嗪（terazosin）是一种选择性α;-肾上腺素能受体阻断剂,临床用来治疗高血压。为确定该药的量效关系,作者对256例轻、中度原发性高血压患者进行了多中心比较研究。剂量为每日1～80 mg,患者随机分为治疗组和安慰剂对照组,每疗程为3个月,剂量逐月加大。常规检测仰卧位舒张压和坐位血压,结果表明,terazosin每日1～5 mg有明显的抗高血压量效关系,除80 mg外,5mg以上（10～40 mg）剂量均不再增强疗效。使用5 mg剂量时,用药期末的药效与峰值药效之比≥50％。

关键词：量效关系抗高血压 terazosin

Separation of chiral drugs with sulfobutylether-β-cyclodextrin bycapillary zone electrophoresis

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Chinese Chemical Letters 1999年第1期10卷 39-42页

作者： Jun Ying LIU Yi Yang DONG Tian Song WANG Hu Wei LIU Al Jin HUANG yi Liang SUNI Zeng Pei SUN(Department of Chemistry． Peking University． Beijing 100871)(Natlonal Institute for the Control of Pharmaceutical and Biological Products，Beijing 100050) Department of Chemistry Peking University Beijing 100871 China Natl. Inst. Contr. Pharmaceutical B. Beijing 100050 China

Sulfobutylether－β－cyclodextrin（SBE－β－CD）was used as a chiral selector tor separatingten chlral drugs with resolution 1．2 by capillary zone electrophoresls（CZE）， The backgroundelectrolylc solution comprised of 120 mmol／L Britton－Robinson buffer（BRB） containing1 ～10mmol／L SBE－β－CD with the pH value adjusted from 5．0－6．8． Five of the drugs were better resolvedthan those previously reported with neutral CDs．

关键词： Chiral separation sulfobutylether-β-cyclodextrin capillary zone electrophoresis anlsodamlne bencynonate econazole esmolol glycopynonate lobeline methoxamine phenylephrine plnacidll terazosin

Targeting on calcium overload mediated brain aging and PD

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Targeting on calcium overload mediated brain aging and PD

中国神经科学学会第十二届全国学术会议

作者： Rong Cai Lei Liu Center of Stroke Beijing Institute for Brain Disorders Capital Medical University

Objective Brain aging associates with increasing intracellular calcium and decreasing brain energy. These two processes are likely correlated. For instance, calcium overload may trigger mitochondrial fragmentation which decreases its energy production. As a feedback, decreased energy output results in failure to maintain calcium gradients across the membrane and promotes calcium overload. Therefore, calcium overload and energy failure together may accelerate brain aging（accelerated aging hypothesis）. Our previous study demonstrated that Miro/Vimar complex served as a mediator of calcium overload and mitochondrial fragmentation. Miro is a small GTPase, well known for its function to regulate mitochondrial morphology and transportation. Vimar is the guanine nucleotide exchange factor of Miro that we identified in Drosophila. The mammalian homolog of Vimar is RAP1 GDS1. Methods To test the accelerated aging hypothesis, we generated transgenic flies to overload calcium and performed genetic manipulation on Miro/Vimar complex. In rodent Parkinson disease（PD） models, energy failure due to mitochondrial dysfunction has been well known to play a key pathophysiological role. Therefore, we select to target energy failure in PD to test the potential application of the hypothesis. To restore cellular energy, our previous study showed that terazosin（TZ） can activate glycolysis in vitro. Here, we tested whether TZ might act as a neuroprotective agent in rodent models of PD. Results 1) Calcium overload in the transgenic flies（overexpressed a leaky cation channel） reduced their locomotion ability, but no lifespan reduction, indicating calcium overload may enhance dementia in flies. 2) TZ could promote aerobic glycolysis and energy recovery in mouse brain in vivo. TZ showed strong rescue effects against the MPTP induced PD models in mice and the 6-OHDA induced PD model in rats. Conclusion Accelerated aging hypothesis is supported by our current results, but more work is still needed

关键词： Mitochondrial dysfunction Parkinson’s disease Energy failure Calcium overload Brain aging terazosin Aerobic glycolysis Miro/Vimar Drosophila genetics

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3种方法治疗前列腺增生症的效果比较

齐鲁医学杂志 2005年第1期20卷 60-61页

作者：周玉海张晶李大军泰山医学院附属医院泌尿外科山东泰安271000 泰安市中心医院外一科

①目的　比较α1 肾上腺素能受体阻滞类药物terazosin、体外射频热疗法及耻骨上经膀胱前列腺切除术治疗前列腺增生症(BPH)的效果。②方法　30例BPH病人应用terazosin 10 mg,每天1 次,用药3 个月;60例BPH病人给予体外射频热疗2 h,随访3个... 详细信息

①目的　比较α1 肾上腺素能受体阻滞类药物terazosin、体外射频热疗法及耻骨上经膀胱前列腺切除术治疗前列腺增生症(BPH)的效果。②方法　30例BPH病人应用terazosin 10 mg,每天1 次,用药3 个月;60例BPH病人给予体外射频热疗2 h,随访3个月;125例BPH病人行耻骨上经膀胱前列腺切除术,随访3个月。统计3种方法治疗前后症状评分、尿流率改善情况及并发症发生率。③结果　手术为最彻底解除下尿路梗阻手段,对临床症状及尿流率改善最优;terazosin在缓解BPH症状上效果较为显著,几乎与手术相仿,但对尿流率改善较差;热疗法在缓解BPH症状及改善尿流率上皆差于手术,在症状缓解上亦差于terazosin。④结论　手术仍为目前治疗BPH最有效手段,terazosin及射频热疗法可以作为无手术指征病人或有绝对禁忌证病人的一种缓解症状的补充疗法。

关键词：前列腺肥大 terazosin 物理疗法前列腺切除术治疗结果