检索结果-南通市图书馆

Differences of Efficacy Between tenofovir alafenamide fumarate and tenofovir Disoproxil fumarate in Pregnant Women With Different Hepatitis B Virus DNA Loads

引用

Infectious Microbes & Diseases 2024年第3期6卷 134-140页

作者： Chengjing Tao Guanlun Zhou Hongxiu Jiang Chao Chen Yuhao Ju Xingran Tao Ping Zhang Shuorong Liu Guorong Han Department of Obstetrics and Gynecology the Second Hospital of NanjingAffiliated Hospital to Nanjing University of Chinese MedicineNanjingChina Department of Obstetrics and Gynecology Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhouChina Department of Hepatology Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhouChina

tenofovir alafenamide fumarate(TAF)has been endorsed by guidelines for blockade ofmother-to-child transmission of hepatitis B virus(HBV),given that its efficacy and safety are comparable to tenofovir disoproxil fumarate(TDF).However,there is a lack of comparative studies regarding the treatment efficacy in patients with diverse viral *** study retrospectively analyzed 96 hepatitis B e antigen(HBeAg)–positive pregnant women with HBV DNA levels of≥2×10^(5) IU/*** on viral loads(HBV DNA levels),participants in the TAF and TDF groups were stratified into three subgroups,namely,the High-G(titer≥8 log_(10) IU/mL),Middle-G(7 log_(10) IU/mL≤titer<8 log_(10) IU/mL)and Low-G(titer<7 log_(10) IU/mL)*** primary endpoint was effectiveness of TAF and TDF in patients with varying viral loads,whereas secondary endpoints were hepatitis B surface antigen(HBsAg)positivity in infants at 7 to 12 months and the safety profile for mothers and *** with baseline levels,median HBV DNA levels in mothers were decreased by 4.51 and 4.09 log_(10) IU/mL in the TAF andTDF groups(P=0.04)predelivery,*** the High-G subgroup,the titers were significantly lower in the TAF group(P=0.045).A higher proportion of patients experienced a virus decline of≥4 log_(10) IU/mL in the TAF group compared with the TDF group,with rates of 78.26% versus 58%(P=0.034),***,the median serum phosphate levels significantly decreased frombaseline to predelivery in the TDF group(P=0.04).Finally,infants in both cohorts tested negative for HBsAg at 7–12 months after ***,our findings indicate that TAF can be considered the preferred option for the treatment of HBeAgpositive pregnant women with HBV DNA levels of≥8 log_(10) IU/mL.

关键词： hepatitis B virus tenofovir alafenamide fumarate tenofovir disoproxil fumara HBeAg positive HBV DNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevention of vertical transmission of hepatitis B virus infection

引用

World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero Veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi Department of Medicine and Surgery University of ParmaParma 43121Italy Department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy Department Neurofarba University of FlorenceFlorence 50129Italy Department Neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B Vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis tenofovir alafenamide fumarate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：