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Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction

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Regenerative Biomaterials 2021年第6期8卷 15-25页

作者： Dingsu Bao Jiacheng Sun Min Gong Jie Shi Bo Qin Kai Deng Gang Liu Shengqiang Zeng Zhou Xiang Shijie Fu Department of Orthopedics Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouSichuan 646000PR China Department of Orthopedics West China HospitalSichuan UniversityChengduSichuan 610041PR China Department of Orthopedics Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan 610075PR China

The treatment of rotator cuff tear is one of the major challenges for orthopedic *** key to treatment is the reconstruction of the tendon-bone interface(TBI).Autologous platelet-rich plasma(PRP)is used as a therapeutic agent to accelerate the healing of tendons,as it contains a variety of growth factors and is easy to *** oxide(GO)is known to improve the physical properties of biomaterials and promote tissue *** this study,PRP gels containing various concentrations of GO were prepared to promote TBI healing and supraspinatus tendon reconstruction in a rabbit *** incorporation of GO improved the ultrastructure and mechanical properties of the PRP *** gels containing 0.5 mg/ml GO(0.5 GO/PRP)continuously released transforming growth factor-b1(TGF-b1)and platelet-derived growth factor(PDGF)-AB,and the released TGF-b1 and PDGF-AB were still at high concentrations,1063.451 pg/ml and814.217 pg/ml,respectively,on the 14th *** vitro assays showed that the 0.5 GO/PRP gels had good biocompatibility and promoted bone marrow mesenchymal stem cells proliferation and osteogenic and chondrogenic *** 12 weeks of implantation,the magnetic resonance imaging,microcomputed tomography and histological results indicated that the newly regenerated tendons in the 0.5 GO/PRP group had a similar structure to natural ***,the biomechanical results showed that the newly formed tendons in the 0.5 GO/PRP group had better biomechanical properties compared to those in the other groups,and had more stable TBI ***,the combination of PRP and GO has the potential to be a powerful advancement in the treatment of rotator cuff injuries.

关键词： platelet-rich plasma graphene oxide controlled release rotator cuff tear tendon-bone interface healing

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Low-intensity pulsed ultrasound therapy: a potential strategy to stimulate tendon-bone junction healing

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 955-963页

作者： Zhi-min YING Tiao LIN Shi-gui YAN Department of Orthopaedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of Orthopaedic Research Brigham and Women's HospitalHarvard Medical SchoolBostonMassachusetts 02115USA

Incorporation of a tendon graft within the bone tunnel represents a challenging clinical problem. Successfulanterior cruciate ligament (ACL) reconstruction requires solid healing of the tendon graft in the bone tunnel. En-hancement of graft healing to bone is important to facilitate early aggressive rehabilitation and a rapid return topre-injury activity levels. No convenient, effective or inexpensive procedures exist to enhance tendon-bone (T-B)healing after surgery. Low-intensity pulsed ultrasound (LIPUS) improves local blood perfusion and angiogenesis,stimulates cartilage maturation, enhances differentiation and proliferation of osteoblasts, and motivates osteogenic differentiation of mesenchymal stem cells (MSCs), and therefore, appears to be a potential non-invasive tool for T-Bhealing in early stage of rehabilitation of ACL reconstruction. It is conceivable that LIPUS could be used to stimulateT-B tunnel healing in the home, with the aim of accelerating rehabilitation and an earlier return to normal activities inthe near future. The purpose of this review is to demonstrate how LIPUS stimulates T-B healing at the cellular andmolecular levels, describe studies in animal models, and provide a future direction for research.

关键词： Low-intensity pulsed ultrasound ACL reconstruction Ultrasound Anterior cruciate ligament reconstruction LIPUS tendon-bone interface healing Fracture healing

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