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Advances in the application of hydrogel-based scaffolds for tendon repair

Genes & Diseases 2024年第4期11卷 296-313页

作者： Renqiang Chen Fanglin Chen Kenian Chen Jian Xu Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Orthopedics The Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou Guangxi 545005China

tendon injuries often lead to joint dysfunction due to the limited self-regeneration capacity of *** tendons is a major challenge for surgeons and imposes a signif-icant financial burden on ***,there is an urgent need to develop effective stra-tegies for repairing injured *** tissue engineering using hydrogels has emerged as a promising approach that has attracted considerable *** possess excellent biocompatibility and biodegradability,enabling them to create an extracellular matrix-like growth environment for *** can also serve as a carrier for cells or other substances to accelerate tendon *** the past decade,numerous studies have made significant prog-ress in the preparation of hydrogel scaffolds for tendon *** review aims to provide an overview of recent research on the materials of hydrogel-based scaffolds used for tendon tis-sue engineering and discusses the delivery systems based on them.

关键词： Application Hydrogel-based Repairscaffolds Review tendon injury Tissue engineering

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An Investigation into Cold-Therapy of the Equine Metacarpus, Following Temperature Changes with Exercise as Well as Post Intervention

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Open Journal of Veterinary Medicine 2020年第10期10卷 185-194页

作者： Simone Bøgelund Nielsen Conny Breining Madvig Adrian Paul Harrison Faculty of Health and Medical Sciences PAS (Physiology) University of Copenhagen Frederiksberg C Copenhagen Denmark

There is some discussion as to whether exercise-induced hyperthermia of the superficial digital flexor tendon (SDFT) affects tenocyte viability and pre-disposes to injury. Cold-therapy is commonly used as a preventative measure and treatment for acute tendon injuries, but only a few studies have evaluated the effect of cold-therapy on metacarpal temperatures in the horse. For this reason, this study has measured skin surface temperatures after moderate exercise and after application of cold-therapy, and additionally monitored the duration of any effects. Four horses were recruited into a semi blinded controlled study with repeated measurements that involved lunged exercise for 16 minutes at moderate intensity. Skin surface temperature was measured using a thermographic camera before and after lunging, and every 40 minutes for two hours post cold-therapy. Cold-therapy was applied using a Jacks Whirlpool Boot with ice-water immersion at a level just distal to the carpus for 20 minutes. The right leg was treated, and the left leg was used as an untreated control. The experiment was conducted twice on all four horses. Moderate exercise resulted in an increase in skin surface temperature of 10°C. Application of cold-therapy for 20 minutes resulted in a reduction in skin surface temperature by 14°C. The effect of cold-therapy persisted for at least 40 minutes post treatment. It is concluded that exercise leads to an increase in skin surface temperature which is counteracted by the application of cold-therapy. These findings would seem to indicate that cold-therapy can be used after exercise to counteract hyperthermia within the metacarpal region of the horse’s leg.

关键词： Horse Thermography Hyperthermia Water Immersion Cooling tendon injury

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