The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophag...
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The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.
BACKGROUND In rotator cuff repair surgery,the double-row technique is widely *** have shown that with increased contact area and pressure between tendon and bone interface,better healing is *** To assess the different...
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BACKGROUND In rotator cuff repair surgery,the double-row technique is widely *** have shown that with increased contact area and pressure between tendon and bone interface,better healing is *** To assess the different suture configurations with the double-row technique and how this influences the contact area of the rotator cuff tendon to *** This was a controlled laboratory study where identical tears were created in 24 fresh porcine shoulders over a 1.5 cm×2.5 cm infraspinatus insertion ***-row repair techniques,with 3 to 4-suture anchors in different configurations(2 medial,2 lateral vs 2 medial,1 lateral vs 1 medial,2 lateral),were employed for three control *** group consisted of eight shoulders with identical repair *** contact areas of the repaired tendon against the tuberosity were determined using pressure sensitive Fujifilm placed between the tendon and *** The mean contact area between tendon and insertion footprint from the imprinted Fujifilm was obtained using computer *** contact area measured from a standard 4-suture anchor double row repair was 75.1±9.3 mm2,whereas areas obtained for the 2 lateral-1 medial and 2 medial-1 lateral anchor configurations were 72.9±5.2 mm2 and 75.0±4.9 mm2 *** statistical significance was noted between the three *** In the technique of double-row repair,using a 3-suture anchor configuration may offer a non-inferior alternative to the standard 4-anchor construct in terms of *** may also result in overall cost reduction and shorter surgical time.
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