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EFFECTS OF MODERATE noise EXPOSURE ON hearing FUNCTION IN C57BL/6J MICE

Journal of Otology 2014年第2期9卷 81-85页

作者： SHI Chuang SHI Lei JIANG Xuejun YANG Shiming LIU Ke Department of Otolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical University Department of Otolaryngology Head and Neck surgery Shiyan Taihe Hospital Department of Otolaryngology Head and Neck surgery Institute of OtolaryngologyChinese PLA General Hospital

Objective To study characteristics of hearing loss after exposure to moderate noise exposure in C57BL/6J mice. Methods Male C57BL/6J mice with normal hearing at age of 5-6 weeks were chosen for this study. The mice were randomly sclccted to be studied immediately after exposure （Group P0）, or 1 day （Group P1）, 3 days （Group P3）, 7 day （Group P7） or 14 days （P14） after exposure. Their before exposure condition served as the normal control. All mice were exposed to a broad-band white noise at 100 dB SPL for 2 hours, ABR thresholds were used to estimate hearing status at each time point. Results ABR threshold elevation was seen at every tested frequency at P0 （P〈0.01）. Elevation at high-frequencies （16 kHz and 32 kHz） was greater than at lower frequencies （4 kHz and 8 kHz, P〈0.05）. From P1 to P14, ABR thresholds continuously improved, and there was no significant difference between P14 and before exposure （P〉0.05）. Conclusion There is a frequency specific re- sponse to 100 dB SPL broad-band white noise in C57BL/6J mice, with the high-frequency being more susceptible. hearing loss induced by moderate noise exposure appears reversible in C57BL/6J mice.

关键词： C57BL/6J mice noise exposure hearing loss temporary noise-induced hearing loss ABR threshold shift

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