A novel organoplatinum(Ⅱ) complex,[Pt(QC1)(H-QC1)Cl](Pt1) bearing 3-(2’-quinolyl)-6,8-dichloro-coumarin(H-QC1) have been first designed.Complex Pt1 selectively displayed obvious cytotoxicities in comparison to cispl...
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A novel organoplatinum(Ⅱ) complex,[Pt(QC1)(H-QC1)Cl](Pt1) bearing 3-(2’-quinolyl)-6,8-dichloro-coumarin(H-QC1) have been first designed.Complex Pt1 selectively displayed obvious cytotoxicities in comparison to cisplatin for A549/DDP(cisplatin-resistant human lung adenocarcinoma) cells and HeLa cervical carcinoma cells,with IC values as low as 100 nM-10.33 μM.In addition,Pt1 display a green-colored luminescent properties,targeted mitochondrial membrane and,thereby induced mainly mitochondria-mediated cell apoptosis.
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