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TELOMERIZATION　OF　TETRAFLUOROETHYLENE　AND　CHLOROTRIFLUOROETHYLENE　WITH　TRICHLOROMETHANESULFONYL　BROMIDE　AS　A　telogen

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Chinese Chemical Letters 1996年第8期7卷 717-720页

作者： Wei Min FU Yu ZBU Si Xun SUN Yu Huang ZHANG Guo Zben JI and Xi Kui JLANG(Shanghal Institute of Organic Chemistry Chinese Academy of Sciences.354 Fenglin Lu.Shanghai 200032) Shanghai Inst. of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 354 Fenglin Lu

Trichioromethanesulfonyl bromide can be used as a ielogen with tetrafluoroethylene andchlorotrifluoroethylene as monomers to give telomerized products CCl3(CF2CF2)*** and CCl3(CF2CFCl)nBrwithout an initiator

关键词： AS telogen TRICHLOROMETHANESULFONYL AND BROMIDE

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Evaluation of a Therapeutic Alternative for telogen Effluvium: A Pilot Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 9-16页

作者： Alfredo Rossi Lara Priolo Alessandra Iorio Enrica Vescarelli Martina Gerardi Daniele Campo Donato Di Nunno Simona Ceccarelli Stefano Calvieri Antonio Angeloni Cinzia Marchese Department of Experimental Medicine Sapienza University of Rome Rome Italy Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy Department of Molecular Medicine Sapienza University of Rome Rome Italy. Italian Orthodermic Institute Rome Italy

Background/Aim: telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair resulting from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belonging to the Ranunculacae family. It has been shown that its major constituent, tymoquinon (TQ), exerts anti-oxidant and anti-inflammatory effects by inhibiting pro-inflammatory mediators, such as cyclooxygenase and prostaglandin D2. The aim of this study is to evaluate the efficacy of NS essential oil as a potential treatment for TE, a pathology characterized by a significant inflammatory component. Study Design/Methods: Twenty patients affected by TE for this double-blind, placebo controlled and randomized study were enrolled. Ten of these patients were treated with a scalp lotion containing 0.5% NS, daily for 3 months, while the other ten patients were treated with placebo daily for 3 months. Videodermatoscopic analysis (Trichoscan Dermoscope Fotofinder?) and evaluation of three independent dermatologists were performed before treatment (T0), after 3 months of treatment (T3) and at the 6 months follow-up (T6). Results: The results showed a significant improvement in 70% of patients treated with NS. Videodermatoscopic analysis showed a significant increment of hair density and hair thickness in patients treated with NS. NS was also able to reduce the inflammation observed in the majority of patients affected by TE. Conclusions: The results of this study suggest that NS can be considered potentially useful for the treatment of TE.

关键词： telogen Effluvium Nigella sativa Hair Density Hair Thickness

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Hair Growth Promoting Effect of Trichoxidil<up>TM</up>: A New Natural Compound for Hair Loss

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第4期10卷 176-190页

作者： Glaucia Labinas Fernando Amaral Valeria Maria de Souza Antunes Maira Jardim Leonardo Mendes Bella Carlos Rocha Oliveira Universidade Anhembi Morumbi S&#227 o Paulo Brazil

Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of TrichoxidilTM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of TrichoxidilTM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);TrichosolTM vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);TrichosolTM vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);TrichosolTM group with 2.5% TrichoxidilTM (n = 5) and Hydroalcoholic vehicle group with 2.5% TrichoxidilTM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of TrichoxidilTM. TrichoxidilTM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that TrichoxidilTM associated with TrichosolTM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: TrichoxidilTM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.

关键词： TrichoxidilTM Hair Growth Anagen telogen KGF IGF-1

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