检索结果-南通市图书馆

Pro-inflammatory cytokines levels in tears and dry eye disease in Parkinson’s disease

Annals of Eye Science 2023年第4期8卷 36-47页

作者： Azyadeh Camacho-Ordonez Atzin Robles-Contreras Oscar Guerrero-Berger Nadezhda Camacho-Ordonez Roberto Rodríguez-Rivas Laura Adalid-Peralta Amin Cervantes-Arriaga Mayela Rodríguez-Violante Anterior Segment Department Hospital Fundacion Nuestra Senora de la LuzPrivate Assistance InstitutionMexico CityMexico Neuroophthalmology Clinic National Institute of Neurology and NeurosurgeryMexico CityMexico Biomedical Research Center Hospital Fundacion Nuestra Senora de la LuzPrivate Assistance InstitutionMexico CityMexico Institute for Immunodeficiency Center for Chronic ImmunodeficiencyMedical CenterFaculty of MedicineAlbert-Ludwigs-University of FreiburgFreiburgGermany Department of Neuroimmunology National Institute of Neurology and NeurosurgeryMexico CityMexico Peripheral Unit for the Study of Neuroinflammation of the Institute of Biomedical Research National Institute of Neurology and NeurosurgeryMexico CityMexico Movement Disorder Clinic National Institute of Neurology and NeurosurgeryMexico CityMexico

Background:Neuroinflammation is an essential event in Parkinson’s disease(PD).Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority among *** study’s objective was to measure tear levels of cytokines in subjects with PD and their association with motor features and the presence of dry eye ***:A total of 16 subjects with PD and 16 age-and sex-matched controls were *** Disorders Society-Unified Parkinson’s Disease Rating Scale(MDS-UPDRS),Hoehn and Yahr(HY)stage scale,Montreal Cognitive Assessment(MoCA),tear break-up time(TBUT),blink rate(BR),Dry Eye Questionnaire 5(DEQ-5)were examined,and pro-inflammatory cytokines[interleukin(IL)-1β,IL-6,IL-8,IL-10,IL-12p70 and tumor necrosis factor-alpha(TNF-α)]were quantified in tears using the BD Cytometric Bead Array Human Inflammatory Cytokine ***:Higher tear TNF-αwere quantified in PD compared to controls(2.94±3.95 vs.0.33±0.49 pg/mL,P=0.008).According to DEQ-5,50.0%(n=8)of PD subjects and 12.5%(n=2)controls had dry eye disease(DED).No differences were found in cytokines concentrations between PD patients with DED compared to those without ***-8 was associated with the HY stage,TBUT,DEQ-5,and a better MoCA score.A higher BR correlated moderately with a lower HY stage(r=−0.645,P=0.007),and DED patients have lower BR in PD(12.14±2.54 vs.9.0±2.06 blinks/minute,P=0.031).Conclusions:PD patients have higher levels of TNF-αin tears than age-and sex-matched ***-8 in tears may be both involved in the severity of the disease and in the development of DED in *** addition,our findings suggest that as HY stage increases,indicating a more advanced stage,BR decreases,indicating greater motor ***,the presence of DED is associated with higher levels of bradykinesia in PD patients,suggesting a potential relationship between DED and motor impairment severity.

关键词： tears pro-inflammatory cytokines dry eye disease(DED) Parkinson’s disease(PD)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comparative Assessment of the Efficacy of Carbomer Gel and Carboxymethyl Cellulose Containing Artificial tears in Dry Eyes

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第5期28卷 592-595页

作者：肖青胡燕华陈飞陈晓敏 Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Ophthalmology Zhongnan Hospital Wuhan University

The present study aimed to compare the clinical efficacy of a 0.4% carbomer gel and 1% carboxymethyl cellulose （CMC） containing artificial tears in treatment of dry eye patients. Sixty subjects with mean age of 45.89 years who had symptoms and signs of dry eye were enrolled in this prospective, investigator-masked and stratified random sampling study. The subjects were divided into two parallel groups with 30 subjects （60 eyes） in each group. One group received carbomer gel, and the other group received 1% CMC containing artificial tears. Subjects received the drops 3 to 4 times or more per day for 3 months. At the first visit time, the precorneal residence time of these two drops was measured. The efficacy was assessed by comparing the subjective symptoms （ocular dry- ness, foreign body sensation, burning sensation and pain）, and the objective test results of tears breakup time, Schirmer＇s test and corneal fluorescein staining prior to the study and after the treat- ment. As a result, the ocular residence time of carbomer gel was significantly longer than that of 1% CMC （P〈0.001）. Most of the primary subjective symptoms and objective test results were improved after treatment in both carbomer gel group and 1% CMC group. As to the improvement of each symptom and objective test result, carbomer gel was more effective than 1% CMC group （P〈0.01）. In conclusion, carbomer gel had longer precorneal residence time and was more effective than 1% CMC in the treatment of patients with dry eyes.

关键词： carbomer gel carboxymethyl cellulose tears dry eye efficacy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous or secondary to intravitreal injections of anti-angiogenic agents retinal pigment epithelial tears in age-related macular degeneration

引用

International Journal of Ophthalmology(English edition) 2014年第4期7卷 681-685页

作者： Pia E.Leon Sandro Saviano Andrea Zanei Marco R.Pastore Elvira Guaglione Alessandro Mangogna Daniele Tognetto University Eye Clinic of Trieste Ospedale Maggiore

·AIM:Toevaluatethevisualfunctionevolutionofretinal pigment epithelial(RPE) tears in patients with age-related macular degeneration(AMD) according to type of occurrence [spontaneous or secondary to anti-vascular endothelial growth factor(anti-VEGF) injection] and the topographic location of the tear after a two-year followup period.·METHODS: A total of 15 eyes of 14 patients with RPE tears in exudative AMD were analyzed retrospectively at the University Eye Clinic of Trieste. Inclusion criteria were: patient age of 50 or older with AMD and RPE tears both spontaneous occurring or post anti-VEGF treatment. Screening included: careful medical history,complete ophthalmological examination, fluorescein angiography(FA), indocyanine green angiography(ICG),autofluorescence and infrared imaging and optical coherence tomography(OCT). Patients were evaluated every month for visual acuity(VA), fundus examination and OCT. Other data reported were: presence of PED,number of injections before the tear, location of the lesion.·RESULTS:Meanfollow-up was24wk(SD±4wk). Atotal of 15 eyes were studied for RPE tear. In 6 cases(40%),the RPE tears occurred within two years of anti-VEGF injections the others occurred spontaneously. In 13cases(86.6%), the RPE tear was associated with pigment epithelial detachment(PED). In 7 cases(46.6%), the RPE tear occurred in the central area of the retina and involved the fovea. Two lesions were found in the parafoveal region, six in the extra-macular area. In all cases visual acuity decreased at the end of the follow-up period(P tears.

关键词： retinal pigment epithelial age-related macular degeneration tears visual acuity anti-vascular endothelial growth factor treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Drought Stress Simulated by Polyethylene Glycol on Seed Germination, Root and Seedling Growth, and Seedling Antioxidant Characteristics in Job’s tears

引用

Agricultural Sciences 2018年第8期9卷 991-1006页

作者： Can Wang Lingbo Zhou Guobing Zhang Yan Xu Xu Gao Ne Jiang Liyi Zhang Mingbo Shao Institute of Upland Food Crops Guizhou Academy of Agricultural Sciences Guiyang China

Two Job’s tears cultivars, yy18-1 (high resistance to drought stress) and yy12-7 (susceptible to drought stress) were used to investigate the responses of seed germination, root and seedling growth, and seedling antioxidant characteristics to drought stress simulated by polyethylene glycol (PEG) 6000 solutions with 0, -0.05, -0.1, -0.15, and -0.2 MPa osmotic potentials. The results showed that the germination energy, germination rate, germination index, root and seedling lengths, root and seedling diameters, root and seedling fresh masses, root and seedling dry masses, and seedling relative water content (RWC) decreased with the decrease of the osmotic potential of PEG 6000 solution. The contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline in seedling increased with the decrease of the osmotic potential of PEG 6000 solution. The activities of peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) in seedling increased and then decreased with the decrease of osmotic potential of PEG 6000 solution. -0.1 MPa was the optimal osmotic potential of PEG 6000 solution simulated drought stress at germination stage for Job’s tears. The proline content and activities of POD and CAT were important mechanisms for the maintenance of drought resistance in Job’s tears seedling.

关键词： Antioxidant Characteristics Drought Stress Germination Growth Job’s tears Polyethylene Glycol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Professional’s skills in assessment of perineal tears after childbirth—A systematic review

引用

Open Journal of Obstetrics and Gynecology 2013年第4期3卷 7-15页

作者： Ann Morris Marie Berg Anna Dencker Centre for Person-Centred Care Institute of Health and Care Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Perineal tears are one of the most common complications of vaginal births and may cause discomfort and pain long time after childbirth. Visual and digital examination of perineal tears is the most common way to assess and classify a perineal tear. Recent research indicates that many tears diagnosed are misclassified. The aim of this systematic literature review was to outline research that investigates healthcare professionals’ clinical knowledge in assessment and classification of perineal tears in connection with childbirth. Searches were performed in PubMed and CINAHL. Six studies on the topic were identified and ?used to collect data for questionnaires. An integrative review was used in the analysis. Poor knowledge in perineal anatomy and lack of training in clinical assessment and classification of perineal trauma was evident among both physicians and midwives. These findings indicate that healthcare providers lack adequate knowledge and that they make incorrect assessments and errors in classification of perineal tears. The training in assessment and classification is crucial. Midwives are in a unique position to improve the standard of care in this field since they are often the first and many times the only to assess the injury.

关键词： Perineum Injuries Perineal tears Obstetrics/Midwifery Education Clinical Competence Review Childbirth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avoiding impression tears in gingival embrasures of anterior preparations

引用

Open Journal of Stomatology 2013年第7期3卷 335-337页

作者： Michele M. Harutunian Angela De Bartolo Denise Estafan Cariology and Comprehensive care Department New York University College of Dentistry New York USA

As restorative dentists, we are faced everyday with decisions about which impression materials and techniques should be used when restoring teeth. The challenge becomes bigger when the patients present with open gingival embrasures, the dreaded “black triangles”, which tops the list of dentist frustration while taking the impression and after preparation of veneers, crowns, bridges, etc. The technique described offers an option to avoid problems related to impressions locking in gingival embrasures and tearing on removal.

关键词： Black Triangles Impression tears Gingival Embrasures Polyvinyl Siloxane Impression Material

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Varicose Veins, Retinal tears and Deep Vein Thrombosis, New Insights into the Causes from Adams Disease

引用

Open Journal of Apoptosis 2015年第3期4卷 59-61页

作者： James David Adams Jr. Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern Cali-fornia Los Angeles CA USA

Adams disease is the consequence of overly active transient receptor potential cation channels (TRP). This case report presents a patient suffering from multiple vascular problems and may provide new insights into the causes of venous problems. Endothelial and smooth muscle cells in veins contain TRP. These channels when activated excessively result in calcium accumulation, oxygen radical formation and apoptosis of endothelial and smooth muscle cells. The death of critical cells in vein valves, may lead to varicose veins. The loss of endothelial cells in venules may lead to retinal tears. Damage to vein walls may lead to a deep vein thrombosis. Transient receptor potential cation channels may be new drug targets of interest in the treatment or prevention of these conditions.

关键词： Transient Receptor Potential Cation Channels Deep Vein Thrombosis Varicose Veins Retinal tears Adams Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical Comparison and Analysis of Decoction of Traditional Chinese Medicine Combined with Ear Acupoint Application and Simple Artificial tears in the Treatment of Dry Eye Syndrome

引用

World Journal of Integrated Traditional and Western Medicine 2019年第1期5卷 29-33页

作者： Tong Tian Li Ruoxi Qi Fei Jiang Xiu Jiang Yanhua Department of Ophthalmology The 4th People's Hospital of ShenyangShengyang 110031China

OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.

关键词： Decoction of tradition Chinese medicine Ear acupoint application therapy Artificial tears Dry eye syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Partial anterior cruciate ligament tears treated with intraligamentary plasma rich in growth factors

引用

World Journal of Orthopedics 2014年第3期5卷 373-378页

作者： Roberto Seijas Oscar Ares Xavier Cuscó Pedro lvarez Gilbert Steinbacher Ramón Cugat Department of Orthopaedic Surgery Fundación García CugatHospital Quirón Barcelona08023 BarcelonaSpain Anatomy Department Universitat Internacional de Catalunya08023 BarcelonaSpain Orthopedic and Trauma Surgery Universitat Internacional de Catalunya08023 BarcelonaSpain Mutualitat Catalana de Futbolistes of Spanish Soccer Federation 08023 BarcelonaSpain

AIM:To evaluate the effect of the application of plasma rich in growth factors(PRGF)-Endoret to the remaining intact bundle in partial anterior cruciate ligament(ACL)***:A retrospective review of the rate of return to play in football players treated with the application of PRGF-Endoret in the remaining intact bundle in partial ACL injuries that underwent surgery for knee *** with knee instability requiring revision surgery for remnant ACL were *** was applied in the wider part of posterolateral bundle and the time it took patients to return to their full sporting activities at the same level before the injury was ***:A total of 19 patients were *** had a Tegner activity level of 10 and the remaining 16level *** time between the injury and the time of surgery was 5.78 wk(SD 1.57).In total,81.75%(16/19)returned to the same pre-injury level of sport activity(Tegner 9-10).17 males and 2 females were *** rate of associated injury was 68.42%meniscal lesions and 26.31%cartilage *** KT-1000 values were normalized in all operated *** patient was not able to return to sport due to the extent of their cartilage *** 15 patients with Tegner activity level 9 returned to play at an average of 16.20 wk(SD1.44)while the 3 patients with Tegner activity level 10did so in 12.33 wk(SD 1.11).CONCLUSION:With one remaining intact bundle the application of PRGF-Endoret in instability cases due to partial ACL tear showed high return to sport rates at pre-injury level in professional football players.

关键词： Anterior cruciate ligament Plasma rich in growth factors Platelet-rich plasma Partial tears anterior cruciate ligament Platelet-rich plasma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rotator cuff tears: An evidence based approach

引用

World Journal of Orthopedics 2015年第11期6卷 902-918页

作者： Senthil Nathan Sambandam Vishesh Khanna Arif Gul Varatharaj Mounasamy Joint Reconstruction Center Department of OrthopaedicsK.G. Hospital and Postgraduate Medical Institute DNB Orthopaedics Department of Ortho- paedicsK.G. Hospital and Postgraduate Medical Institute Princess Alexandra Hospital VCU Medical Center Ambulatory Care Center

Lesions of the rotator cuff(RC) are a common occurrence affecting millions of people across all parts of the globe. RC tears are also rampantly prevalent with an agedependent increase in numbers. Other associated factors include a history of trauma, limb dominance, contralateral shoulder, smoking-status, hypercholesterolemia, posture and occupational dispositions. The challenge lies in early diagnosis since a high proportion of patients are asymptomatic. Pain and decreasing shoulder power and function should alert the heedful practitioner in recognizing promptly the onset or aggravation of existing RC tears. Partial-thickness tears(PTT) can be bursalsided or articular-sided tears. Over the course of time, PTT enlarge and propagate into full-thickness tears(FTT) and develop distinct chronic pathological changes due to muscle retraction, fatty infiltration and muscle atrophy. These lead to a reduction in tendon elasticity and viability. Eventually, the glenohumeral joint experiences a series of degenerative alterations- cuff tear arthropathy. To avert this, a vigilant clinician must utilize and corroborate clinical skill and radiological findings to identify tear progression. Modern radio-diagnostic means of ultrasonography and magnetic resonance imaging provide excellent visualization of structural details and are crucial in determining further course of action for these patients. Physical therapy along with activity modifications, antiinflammatory and analgesic medications form the pillars of nonoperative treatment. Elderly patients with minimal functional demands can be managed conservatively and reassessed at frequent intervals. Regular monitoring helps in isolating patients who require surgical interventions. Early surgery should be considered in younger, active and symptomatic, healthy patients. In addition to being costeffective, this helps in providing a functional shoulder witha stable cuff. An easily reproducible technique of maximal strength and sturdiness

关键词： Rotator cuff tears Partial thickness tears Full thickness tear Natural history Ultrasonography Magnetic resonance imaging Single row repair Double row repair Healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：