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Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy

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Chinese Chemical Letters 2024年第12期35卷 198-205页

作者： Jiahao Liu Peng Liu Junhong Duan Qiongxuan Xie Jie Feng Hongpei Tan Ze Mi Ying Li Yunjie Liao Pengfei Rong Wenhu Zhou Xiang Gao Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Radiology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Nuclear Medicine XiangYa HospitalCentral South UniversityChangsha 410008China Key Laboratory of Biological Nanotechnology NHCChangsha 410013China Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Nursing Hunan Provincial People’s Hospital(The First Affiliated Hospital of Hunan Normal University)Changsha 410005China State Key Laboratory of Toxicology and Medical Countermeasures Institute of Pharmacology and ToxicologyBeijing 100050China

Radiotherapy(RT)is a widely used cancer treatment,and the use of metal-based nano-radiotherapy sensitizers has shown promise in enhancing its ***,efficient accumulation and deep penetration of these sensitizers within tumors remain *** this study,we present the development of bismuth/manganese biomineralized nanoparticles(Bi Mn/BSA)with multiple radiosensitizing mechanisms,including high atomic number element-mediated radiation capture,catalase-mimic oxygenation,and activation of the stimulator of interferon genes(STING)***,we demonstrate that low-dose RT induces the recruitment of macrophages and subsequent upregulation of Matrix metalloproteinases(MMP)-2 and MMP-9 that degrade the extracellular matrix(ECM).This dynamic process facilitates the targeted delivery and deep penetration of Bi Mn/BSA nanoparticles within tumors,thereby enhancing the effectiveness of *** combining low-dose RT with Bi Mn/BSA nanoparticles,we achieved complete suppression of tumor growth in mice with excellent *** study provides a novel and clinically relevant strategy for targeted nanoparticle delivery to tumors,and establishes a safe and effective sequential radiotherapy approach for cancer *** findings hold great promise for improving the outcomes of RT and advancing the field of nanomedicine in cancer therapy.

关键词： Radiotherapy sensitizers Metal-based nanoparticles targeted nanoparticle delivery STING pathway activation Sequential radiotherapy

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