检索结果-南通市图书馆

Nano Research 2023年第5期16卷 7216-7226页

作者： Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate *** studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory ***,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease *** the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease *** STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted *** results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s ***,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies.

关键词： sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease

Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1367-1401页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu José M.Pérez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affiliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples Federico IINaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarh AjmerRajasthan 305817India CSIR-Indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(IIIT-D)Okhla Industrial EstatePhase IIINew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologíaIPNA-CSICSan Cristóbal de La Laguna 38206TenerifeSpain

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every *** the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive *** the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse *** drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years *** field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival *** growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological ***-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific *** present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.

关键词： Antimicrobial peptides Cancer therapies Clinical trials Combination therapy Immunotherapy Patient survival Personalized medicine targeted drug delivery

Modeling of highly efficient drug delivery system induced by self-assembly of nanocarriers: A density functional study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2013年第2期56卷 249-255页

作者： JIANG Jian CAO DaPeng Division of Molecular and Materials Simulation State Key Lab of Organic-Inorganic Composites Beijing University of Chemical Technology

Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-like nanocarrier by using the coarse grained model-based density functional theory, which combines a modified fundamental measure theory for the excluded-volume effects, Wertheim's first-order thermodynamics perturbation theory for the chain connectivity and the mean field approximation for van der Waals attraction. For comparison, the monomer nanocarrier TDD system and the no nanocarrier one are also investigated. The results indicate that the drug delivery capacity of rod-like nanocarriers is about 62 times that of the no nanocarrier one, and about 6 times that of the monomer nanocarriers. The reason is that the rod-like nanocarriers would self-assemble into the smectic phase perpendicular to the membrane surface. It is the self-assembly of the rod-like nanocarriers that yields the driving force for the targeted delivery of drugs inside the cell membrane. By contrast, the conventional monomer nanocarrier drug delivery system lacks the driving force to deliver the drugs into the cell membrane. In short, the novel rod-like nanocarrier TDD system may improve the drug delivery efficiency. Although the model in this work is simple, it is expected that the system may provide a new perspective for cancer targeted therapy.

关键词： interface polymers microstructure statistical thermodynamics self-assembly targeted drug delivery

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery Special Issue:Emerging Investigators

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第2期5卷 112-129页

作者： Fariba Mehvari Vahid Ramezanzade Parvin Asadi Nem Singh Jaewon Kim Mohammad Dinari Jong Seung Kim Department of Chemistry Isfahan University of TechnologyIsfahanIslamic Republic of Iran Department of Medicinal Chemistry School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIslamic Republic of Iran Department of Chemistry Korea UniversitySeoulSouth Korea

The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs,particularly for aggressive and difficult-totreat *** organic frameworks(COFs)are emerging as innovative porous nanomaterials in drug delivery systems(DDS),due to their unique properties,including the metal-free organic skeleton,predetermined structures and pore geometries,high porosity,large surface area,facile surface modification potential,and good *** characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise *** review emphasizes the importance of donor-acceptor-based COFs,which provide channels for charge transportation,and we also explore how theπ-conjugated skeleton of COFs enhances its long-acting fluorescent properties and facilitates drug uptake via cell *** this review primarily focuses on recent advancements in COF-based targeted DDS,it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential ***,it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells,improving treatment efficiency while reducing adverse side effects.

关键词： cancer treatment controlled release covalent organic frameworks nanotechnology photodynamic therapy targeted drug delivery

Upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第12期7卷 91-103页

作者： Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang Department of Vascular Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang UniversityNanchangJiangxi330006PR China The National Engineering Research Center for Bioengineering drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchangJiangxi330088PR China College of Chemistry Nanchang UniversityNanchangJiangxi330088PR China School of Public Health&Jiangxi Provincial Key Laboratory of Preventive Medicine NanchangJiangxi330088PR China

Thromboembolism is the leading cause of cardiovascular ***,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on *** addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of *** address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue *** nanoplatform can target and enrich in the thrombus *** thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional *** with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment.

关键词： targeted drug delivery Upconversion nanoparticles Controlled release Thrombus Anticoagulation

Functionalized Hyperbranched Aliphatic Polyester Polyols: Synthesis,Properties and Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第12期40卷 1567-1585,I0006页

作者： Aleksei Maksimov Gennadii Kutyrev Kazan National Research Technological University Department of General Chemical TechnologiesKazan 420015Russia

Recently, hyperbranched polymers(HBPs), which differ significantly in structure and properties from linear, cross-linked and branched analogs, have become increasingly important. HBP have a spatial unloaded core and a shell of branched monomer units(dendrons), in which functional groups are predominantly located in the surface layer. The size of macromolecules ranges from 2 nm to 100 nm. Currently, there are a fairly large number of publications in the literature devoted to the modification of hyperbranched polyester polyols with various functional groups and the assessment of the potential for their use. However, there are no review articles on this topic in recent years. In this regard, it is relevant to generalize the latest achievements in the field of synthesis, properties and application of hyperbranched polyester polyols with terminal oxygen, nitrogen, silicon, sulfur and organophosphorus fragments. The advantage of hyperbranched polyester polyols of the Boltorn H series is their industrial availability, biodegradability, nanoscale, non-toxicity and high solubility in various polar solvents due to short monomer units, as well as the presence of reactive terminal hydroxyl groups. Functionalization of hyperbranched polyester polyols at hydroxyl groups is mainly carried out by addition of acid anhydrides, iso(thio)cyanates, alkenes, lactides, lactones, lactams, epoxy compounds or reactions with halogenated compounds(alkyl halides, acid chlorides). In some cases, for the functionalization of polyester polyols special linkers are used, such as acid chlorides of unsaturated or dicarboxylic acids, diisocyanates, etc., which provide covalent bonding of the hyperbranched polymer with the target functional group. The obtained derivatives of hyperbranched polyesters are widely used in such areas as biomedicine, pharmacy, paints and varnishes, they are also used as catalysts, membranes, multifunctional coatings, plasticizers and polymer stabilizers.

关键词： Hyperbranched polymers Hyperbranched polyester polyols Curable coatings targeted drug delivery Membranes

Dynamics of magnetic microbubble transport in blood vessels

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2023年第9期32卷 293-303页

作者：陈杰王成会莫润阳 Institute of Shaanxi Key Laboratory of Ultrasonics Shaanxi Normal UniversityXi'an 710119China

Magnetic microbubbles(MMBs)can be controlled and directed to the target site by a suitable external magnetic field,and thus have potential in therapeutic drug-delivery ***,few studies focus on their dynamics in blood vessels under the action of magnetic and ultrasonic fields,giving little insight into the mechanism generated in diagnostic and therapeutic *** this study,equations of MMBs were established for simulating translation,radial pulsation and the coupled effect of ***,the acoustic streaming and shear stress on the vessel wall were also presented,which are associated with drug *** results suggest that the magnetic pressure increases the bubble pulsation amplitude,and the translation coupled with pulsation is manipulated by the magnetic force,causing retention in the target *** the bubbles approach the vessel wall,the acoustic streaming and shear stress increase with magnetic field *** responses of bubbles to a uniform and a gradient magnetic field were explored in this *** mathematical models derived in this work could provide theoretical support for experimental phenomena in the literature and also agree with the reported models.

关键词： magnetic microbubbles targeted drug delivery ultrasound magnetic field

Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第4期36卷 479-487页

作者： Dan-Hua Zhou Guan Zhang Qing-Song Yu Zhi-Hua Gan National University of Singapore Environmental Research Institute(NERI) National University of SingaporeSingapore 117576Singapore Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-inorganic Composite MaterialsCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China Department of Urology China-Japan Friendship HospitalBeijing 100029China

In this study, a targeting micellar drug delivery system was developed for intravesical instilled chemotherapy of bladder cancer. The amphiphilic diblock copolymer poly（？-caprolactone）-block-poly（ethylene glycol）（PCL-b-PEO） with functional amino group（NH2） at the end of PEO block was synthesized. Then the copolymer was conjugated with folic acid（FA） and fluorescein isothiocyannate（FITC） via the PEO-NH2 terminus, and then assembled into micelles with the target moiety and fluorescence labeling. In addition, drug loaded micelles were also fabricated with anticancer drug doxorubicin（DOX） encapsulated in the hydrophobic core. The micelles were characterized in terms of size, drug loaded efficiency and critical micellization concentration（CMC） by means of DLS, UV and fluorescence spectra. In vitro cellular uptake and cytotoxicity studies showed that FA modified PCL-b-PEO-FA micelles have a greater targeting efficiency to human bladder cancer cell（T-24 cell） compared to PCL-b-PEO-NH2 micelles due to the conjugation of FA on the surface, while no targeting effect to normal tissue originated human embryonic kidney 293（HEK-293） cells was observed, enabling the micelles a promising drug carrier for intravesical instilled chemotherapy of bladder cancer.

关键词： targeted drug delivery Superficial bladder cancer Intravesical instilled chemotherapy Folic acid Micelles

Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第7期16卷 9688-9700页

作者： Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu Department of Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Radiation Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Geriatrics Institute of Zhejiang Province Department of GeriatricsAffiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310030China Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou 310058China TCM Dispensary Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Department of Breast Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China

Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat *** treatment options that can accurately target CPRC is an important issue with urgent *** this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of *** combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic *** nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and ***(DOX)was selected as the chemotherapeutic agent for *** terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug *** nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)*** the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in *** work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision.

关键词： castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy

Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第5期34卷 449-455页

作者： Lu Tang Mengying Xie Jing Li Yijun Mei Yuqi Cao Qiaqia Xiao Haijuan Dong Yuhui Zhang Wei Wang Department of Pharmaceutics State Key Laboratory of Natural MedicinesSchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China The Public Laboratory Platform China Pharmaceutical UniversityNanjing 210009China Department of Spine Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy ***,there are very limited researches for IMSCT treatment using *** fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT *** this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of *** to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery.

关键词： Mesenchymal stem cell Intramedullary spinal cord tumor Metformin Nanosystem targeted drug delivery