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第十届全国酶学学术讨论会

作者： Hua-Rong Wang Lu Ying 王晓云 College of Life Science Shandong Agricultural University State Key Laboratory of Crop Biology Shandong Agricultural University

Regulatory protein disulfide bonds serve as key signaling elements and the formation and the reduction reactions of the disulfides are specifically catalyzed in vivo.A novel protein in Arabidopsis chloroplast encoded by gene At4g35760 which named AtVKOR-DsbA,was found to be involved in disulfide formation *** is a fusion protein containing a homolog of the catalytic subunit of the mammalian protein Vitamin K epoxide reductase(VKOR) and thioredoxin-like domain homologous to the *** protein *** electron transfer

关键词： AtVKOR-Dsb AtDsbA target protein Thioredoxin-like

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Identification of marine natural product Pretrichodermamide B as a STAT3 inhibitor for efficient anticancer therapy

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Marine Life Science & Technology 2023年第1期5卷 94-101页

作者： Rui Li Yue Zhou Xinxin Zhang Lujia Yang Jieyu Liu Samantha M.Wightman Ling Lv Zhiqing Liu Chang-Yun Wang Chenyang Zhao School of Medicine and Pharmacy Institute of Evolution&Marine BiodiversityCollege of Food Science and EngineeringOcean University of ChinaQingdao266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao266237China Department of Cancer Biology Lerner Research InstituteCleveland ClinicClevelandOH44195USA

The Janus kinase(JAK)/signal transducer and activator of transcription 3(STAT3)regulates the expression of various critical mediators of cancer and is considered as one of the central communication nodes in cell growth and *** natural products(MNP)represent great resources for discovery of bioactive lead compounds,especially anti-cancer *** the medium-throughput screening of our in-house MNP library,Pretrichodermamide B,an epidithiodiketopiperazine,was identified as a JAK/STAT3 signaling *** studies identified that Pretrichodermamide B directly binds to STAT3,preventing phosphorylation and thus inhibiting JAK/STAT3 ***,it suppressed cancer cell growth,in vitro,at low micromolar concentrations and demonstrated efficacy in vivo by decreasing tumor growth in a xenograft mouse *** addition,it was shown that Pretrichodermamide B was able to induce cell cycle arrest and promote cell *** study demonstrated that Pretrichodermamide B is a novel STAT3 inhibitor,which should be considered for further exploration as a promising anti-cancer therapy.

关键词： Pretrichodermamide B Signal transducer and activator of transcription 3(STAT3) Marine natural products target protein In vivo anti-cancer efficacy

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2-（2-azidoethyl）-2,5-di-（4,5-Dimethoxy-2-nitro-benzyloxy）-2,5-dihydr ofuran as a potential photoaffinity crosslinking reagent

2-（2-azidoethyl）-2,5-di-（4,5-Dimethoxy-2-nitro-benzyloxy...

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第十届全国化学生物学学术会议

作者： Jiahui Li Mengdi Shang Xiaoping Zhou Zhen Xi Chuanzheng Zhou State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology College of ChemistryNankai University

Photoaffinity crosslinking is widely used in biomolecules interaction studies. A few photoreactive groups, such as azide, diazirine and benzophenone, have introduced to fulfill such a purpose. However, all of these groups suffer from low cross-linking efficiency as a result of either low reactivity or photodecomposition. We design and synthesized 2-（2-azidoethyl）-2,5-di-（4,5-Dimethoxy-2-nitro-benzyloxy）-2,5-dihydrofuran as a new photoaffinity crosslinking reagent. The azid function on this molecule allow it to be readily anchored to alkyne modified biomolecules. Photo irradiation of the molecule at 350 nm furnish cis-enedione, which is quite stable but crosslink with primary amines quickly and quantitatively. The unique property make this molecule prominent in mapping out protein residues involved in protein–DNA interactions and to trapping/identifying proteins that interact with DNA.

关键词： Photoaffinity crosslinking DNA-protein interaction target protein

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