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tanshinone iia Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis

Engineering 2022年第12期19卷 128-138页

作者： Shasha Bai Sainan Cui Wenhao Wen Elaine Lai-Han Leung Jing Bai Huiyuan Lin Yongfei Cui Lei Yang Zhongqiu Liu Yuan Zheng Rong Zhang School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao 999078China Cardiothoracic Surgery Department The Second Clinical College of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Chinese MedicineGuangzhou 510006China

It is necessary to develop a new strategy for treatment of lung cancer since it is the main cause of cancer *** iia(tan iia),an active ingredient of a commonly used traditional Chinese herb Salvia miltiorrhiza,provides a new direction to develop a new strategy for the *** has been found that tan iia could inhibit lung cancer in vitro and in vivo by inducing autophagic *** iia increased apoptotic cells and the expression of cleaved caspase 3 and cleaved caspase 9,decreased B-cell lymphoma-2(Bcl-2)/Bcl-2 associated X protein(Bax)ratio in human non-small cell lung cancer(NSCLC)cell lines,which was promoted by an autophagy activator Rapamycin,and weaken by autophagy inhibitor 3-methyladenine(3-MA).In addition,tan iia induced more autophagosomes,up-regulated light chain 3b(LC-3B)I and LC-3B II conversion and less sequestosome 1(SQSTM1/p62)expression,which cannot be weakened by the caspase 3 ***,overexpression of LC-3B gene(LC3B)and downregulation of autophagic gene 5(ATG5)further confirmed that tan iia induced autophagic apoptosis in NSCLC cell ***-1 gene(BECN1)overexpression and silence attenuated the effects of tan iia,suggesting autophagic apoptosis that tan iia induced was dependent on ***,our study demonstrated a new treatment mechanism of tan iia and suggested that tan iia is a potential new anti-cancer therapeutic option.

关键词： tan iia Autophagy Apoptosis Beclin-1

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