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selenium speciation determines the angiogenesis effect through regulating selenoproteins to trigger ROS-mediated cell apoptosis and cell cycle arrest

引用

Chinese Chemical Letters 2023年第11期34卷 184-190页

作者： Bin Feng Yan Zhang Ting Liu Leung Chan Tianfeng Chen Jianfu Zhao Department of Oncology Research Center of Cancer Diagnosis and Therapythe First Affiliated HospitalJinan UniversityGuangzhou 510632China

Tumor angiogenesis is closely related to tumor development,immune escape,and drug ***,the development of effective anti-tumor angiogenesis drugs is of great research *** the current clinical angiogenesis inhibitors have achieved certain efficacy,they also pose the problems of limited and short duration of efficacy,drug resistance,and intrinsic ***-tumor angiogenesis strategies targeting endothelial cells(ECs)have attracted widespread attention in the development of highly effective and low toxicity anti-angiogenesis *** have verified that the trace element selenium(Se)can inhibit tumor growth by inhibiting tumor angiogenesis through different ***,it is unclear whether Se speciation has different effects on anti-tumor ***,we found that Se exhibited effective anti-angiogenic activity,and its mechanisms of activity were determined by its chemical *** Se can significantly inhibit tumor angiogenesis by targeting thioredoxin reductase(TrxR)to trigger cell apoptosis and cell cycle arrest and by increasing reactive oxygen species(ROS)production in *** Se can induce cell cycle arrest and increase ROS production in ECs,showing promising anti-angiogenic *** nanoparticles(SeNPs)slightly inhibit tumor angiogenesis by inducing apoptosis and cell cycle arrest and by increasing the production of *** summary,this study elucidates the anti-angiogenic activity of Se speciation control with a view to providing a scientific reference for the design and development of novel Se-based highly effective and low toxicity angiogenesis inhibitors.

关键词： Se speciation Angiogenesis Apoptosis Reactive oxygen species txnrd selenium

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