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trove2 regulated invasion and migration of hepatocellular carcinoma cells via heparanase

Oncology and Translational Medicine 2024年第2期10卷 66-72页

作者： Niangmei Cheng Xiaoyuan Zheng Jingyun Huang FeiWang Yang Wang Yue Zhong Yingchao Wang Gaoxiong Wang Bixing Zhao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025P.R.China Mengchao Med-X Center Fuzhou UniversityFuzhou 350116P.R.China Department of Surgery Quanzhou Maternity and Children's Hospital700 Fengze StreetQuanzhouFujianChina Department of General Surgery the Second AffiliatedHospitalFujian Medical UniversityQuanzhouFujianChina

Background:The role of trove domain family member 2(trove2)has been well-demonstrated in autoimmune diseases;however,its involvement in liver cancer remains ***,this study aimed to explore the biological function and clinical significance of trove2 in hepatocellular carcinoma(HCC).Methods:The expression level of trove2 was analyzed in HCC and paired adjacent tissue samples using real-time reverse transcription-quantitative polymerase chain *** impact of trove2 on migration and invasion in HCC cells was analyzed through Transwell assays and Western ***-throughput transcriptome sequencing and bioinformatics analyses were performed to identify downstream target ***-complementation experiments were employed to verify the influence of downstream proteins on trove2-induced invasion and migration of HCC ***:trove2 exhibited significant overexpression in liver cancer tissue,correlating with shorter overall *** of trove2 facilitated the invasion,metastasis,and epithelial-mesenchymal transition(EMT)process of HCC cells,whereas trove2 knockdown restrained migration,invasion,and EMT in these *** sequencing and bioinformatics analysis identified heparanase(HPSE)as a downstreamtarget protein of *** back-complementation experiments provided evidence that HPSE overexpression promoted trove2-mediated prometastasis ***,the study revealed that trove2 was capable of regulating the EMT pathway through GSK-3β***:trove2 facilitated the invasion,migration,and EMT process ofHCC cells through phosphorylation of the HPSE/GSK-3βaxis,indicating its significance as an important protein in tumor progression.

关键词： Epithelial-mesenchymal transition(EMT) Heparanase(HPSE) Hepatocellular carcinoma(HCC) trove2

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