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Structural control of magnetic nanoparticles for positive nuclear magnetic resonance imaging

NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-12页

作者： Ali, Zulaikha Zhang, Yunfei Kaul, Michael G. Truong, Billy Bhanot, Deepika Adam, Gerhard Li, Yuan-Yuan Wei, He Calif State Univ Dept Chem & Biochem Fresno CA 93740 USA Univ Med Ctr Hamburg Eppendorf Ctr Radiol & Endoscopy Dept Diagnost & Intervent Radiol & Nucl Med D-20246 Hamburg Germany Oak Ridge Natl Lab Chem Sci Div Oak Ridge TN 37831 USA

In addition to the tens of millions of medical doses consumed annually around the world, a vast number of nuclear magnetic resonance imaging (MRI) contrast agents are being deployed in MRI research and development, offering precise diagnostic information, targeting capabilities, and analyte sensing. Superparamagnetic iron oxide nanoparticles (SPIONs) are notable among these agents, providing effective and versatile MRI applications while also being heavy-metal-free, bioconjugatable, and theranostic. We designed and implemented a novel two-pronged computational and experimental strategy to meet the demand for the efficient and rigorous development of SPION-based MRI agents. Our MATLAB-based modeling simulation and magnetic characterization revealed that extremely small maghemite SPIONs in the 1-3 nm range possess significantly reduced transversal relaxation rates (R-2) and are therefore preferred for positive (T-1-weighted) MRI. Moreover, X-ray diffraction and X-ray absorption fine structure analyses demonstrated that the diffraction pattern and radial distribution function of our SPIONs matched those of the targeted maghemite crystals. In addition, simulations of the X-ray near-edge structure spectra indicated that our synthesized SPIONs, even at 1 nm, maintained a spherical structure. Furthermore, in vitro and in vivo MRI investigations showed that our 1-nm SPIONs effectively highlighted whole-body blood vessels and major organs in mice and could be cleared through the kidney route to minimize potential post-imaging side effects. Overall, our innovative approach enabled a swift discovery of the desired SPION structure, followed by targeted synthesis, synchrotron radiation spectroscopic studies, and MRI evaluations. The efficient and rigorous development of our high-performance SPIONs can set the stage for a computational and experimental platform for the development of future MRI agents.

关键词： Magnetic nanoparticles Structure control Nuclear magnetic resonance imaging Modeling simulation X-ray absorption fine structure IRON-OXIDE NANOPARTICLES transverse relaxation NMR SIGNAL PARTICLES BEHAVIOR TISSUES SPHERES

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Using endogenous glycogen as relaxation agent for imaging liver metabolism by MRI

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Fundamental Research 2023年第4期3卷 481-487页

作者： Shizhen Chen Mou Jiang Yaping Yuan Baolong Wang Yu Li Lei Zhang Zhong-Xing Jiang Chaohui Ye Xin Zhou State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Glycogen plays essential roles in glucose *** glycogen in the liver,the major glycogen reservoir in the body,may shed new light on many metabolic disorders.^(13)C magnetic resonance spectroscopy(MRS)has become the mainstream method for monitoring glycogen in the ***,the equipment of special hard-ware to standard clinical magnetic resonance imaging(MRI)scanners limits its clinical ***,we utilized endogenous glycogen as a T_(2)-based relaxation contrast agent for imaging glycogen metabolism in the liver in *** in vitro results demonstrated that the transverse relaxation rate of glycogen strongly correlates with the concentration,pH,and field *** on the Swift-Connick theory,we characterized the exchange property of glycogen and measured the exchange rate of glycogen as 31,847 Hz at 37°***,the viscosity and echo spacing showed no apparent effect on the transverse relaxation *** unique feature enables vi-sualization of glycogen signaling in vivo through T_(2)-weighted *** hours-post intraperitoneal injection of glucagon,a clinical drug to promote glycogenolysis and gluconeogenesis,the signal intensity of the mice’s liver increased by 1.8 times from the T_(2)-weighted imaging experiment due to the decomposition of *** study provides a convenient imaging strategy to non-invasively investigate glycogen metabolism in the liver,which may find clinical applications in metabolic diseases.

关键词： Glycogen Magnetic resonance imaging Liver T2-weighted imaging transverse relaxation

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