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Progress in Single Cell Sequencing Technology

Journal of Zoological Research 2019年第1期1卷 20-26页

作者： Qicai Ma Wenli Wu Na Ye Xingdong Wang Ping Yan Heping Pan College of Life Science and Engineering Northwest University For NationalitiesLanzhouGansu730030China Lanzhou Institute of Animal Husbandry and Veterinary Medicine Chinese Academy of Agricultural SciencesLanzhouGansu730050China

Cells are the basic unit of life structure and life *** of the complex micro-environment of cells,the content of components that play a key role is relatively small,so single-cell analysis is extremely *** recent years,single-cell sequencing technology has been developed and ***-cell sequencing can reveal the composition and physiological diversity of cells,and the existing single-cell separation technology,single-cell whole genome amplification technology,single The principles and applications of cell whole transcriptome amplification technology and single cell transcriptome sequencing are summarized and summarized.

关键词： Single cell isolation Single cell sequencing Whole genome transcriptome

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To explore the potential vitiligo treatment mechanism of Piperine in Piperis Longi Fructus via network pharmacology and bioinformatics strategies

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TMR Integrative Medicine 2021年第10期5卷 1-10页

作者： Ji-Hong Li Jia-Yu Zhang Yuan-Xia Zou Department of Dermatology Leshan Traditional Chinese Medicine HospitalLeshanSichuan614001China The First Clinical Medical College of Yunnan University of Traditional Chinese Medicine KunmingYunnan650051China Department of Newborn Medicine Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhouSichuan646000Chin

Objective:To explore the mechanism of Piperine of Piperis Longi Fructus in the treatment of vitiligo based on network pharmacology and ***:Piperine,the active component of Piperis Longi Fructus,was screened from Traditional Chinese Medicine Systems Pharmacology,and the target network and protein interaction network of piperine-vitiligo were *** analyzed the cross targets,GO function,and KEGG pathway *** the GEO database,vitiligo gene expression profile chips GSE65127 and GSE75819 were selected for differential gene screening and gene set enrichment *** potential key signal pathways of piperine in the treatment of vitiligo were identified by transcriptome microarray data ***:31 potential targets of piperine in the treatment of vitiligo were found,of which 9 targets such as ESR1,AKT1,and IGF1 were closely related to the treatment of *** analysis showed that signal pathways such as PI3K-Akt,MAPK,and Melanogenesis were related to piperine's mechanism in treating *** cross-validation of chip analysis results confirmed that Melanogenesis is a potential key signal pathway for piperine in vitiligo ***:This study discusses the potential targets and signal pathways of piperine in the treatment of vitiligo,which helps clarify the mechanism of piperine in the treatment of vitiligo and provides a theoretical basis for the clinical treatment of *** also provides direction for the research and development of new drugs for vitiligo.

关键词： Piperine Vitiligo Network pharmacology transcriptome Action mechanism

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